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141.
Martínez-Pardo ME Hernández L Reyes-Frías Mde L Luna-Zaragoza D 《Cell and tissue banking》2010,11(4):393-395
This short communication describes how some Mexican tissue banks have established their own system for coding and traceability
of tissues. 相似文献
142.
Sheila A. Dugan Susan A. Everson‐Rose Kelly Karavolos Elizabeth F. Avery Deidre E. Wesley Lynda H. Powell 《Obesity (Silver Spring, Md.)》2010,18(6):1260-1265
The purpose of our study was to determine whether self‐reported physical activity (PA), including recreational, household, and exercise activities, is associated with intra‐abdominal fat (IAF) in community‐dwelling white and black midlife women. We performed a cross‐sectional study of 369 women from the Chicago site of the Study of Women's Health Across the Nation (SWAN) ancillary study, the SWAN Fat Patterning Study. PA level was the independent variable, and IAF, assessed by computerized tomography (CT) scan, was the dependent variable. Measures were obtained at SWAN Fat Patterning Baseline visit between August 2002 and December 2005. Linear regression models explored the association between PA and IAF. The first model included IAF as the outcome and total score PA as the main predictor, adjusting for total percent fat mass, age, and ethnicity. The second model included education, parity, sex hormone–binding globulin (SHBG) level, and depressive symptoms, measured by Center for Epidemiological Studies‐Depression (CES‐D) scale. Each 1‐point higher total PA score was associated with a 4.0 cm2 lower amount of IAF (P = 0.004), independent of total percent fat mass, age, ethnicity, SHBG level, educational level, CES‐D, and parity. Associations did not differ between white and black women. This study demonstrates a significant negative association between PA and IAF independent of multiple covariates in midlife women. Our findings suggest that motivating white and black women to increase PA during midlife may lessen IAF, which may have a positive impact on subsequent development of diabetes and cardiovascular disease. 相似文献
143.
Animals were given five cycles of an activity anorexia (AA) procedure in order to determine the effect of additional experience on eating, running, and weight loss. Female Sprague-Dawley rats were given a 1h meal and allowed access to a running wheel for the remainder of each day. Upon reaching 75% of free-feeding body weight, each animal was denied wheel access and given ad libitum food until it regained the lost weight. Then, food was again restricted and wheel access provided. Sedentary control animals were placed on the restricted feeding schedule for the median number of days experimental animals required to reach weight loss criterion. Experimental animals showed adaptation by increasing food consumption and decreasing the rate of weight loss despite an increase in running across cycles. Additionally, the distribution of running shifted gradually so that during the later cycles, much of the running occurred in the hours just before feeding. The results support the hypothesis that running interferes with adaptation to the restricted feeding schedule and also that the marked increase in anticipatory behavior during the later cycles is primarily responsible for the maintenance of AA. 相似文献
144.
Lynda M Groocock Minghua Nie John Prudden Davide Moiani Tao Wang Anton Cheltsov Robert P Rambo Andrew S Arvai Chiharu Hitomi John A Tainer Karolin Luger J Jefferson P Perry Eros Lazzerini‐Denchi Michael N Boddy 《EMBO reports》2014,15(5):601-608
The post‐translational modification of DNA repair and checkpoint proteins by ubiquitin and small ubiquitin‐like modifier (SUMO) critically orchestrates the DNA damage response (DDR). The ubiquitin ligase RNF4 integrates signaling by SUMO and ubiquitin, through its selective recognition and ubiquitination of SUMO‐modified proteins. Here, we define a key new determinant for target discrimination by RNF4, in addition to interaction with SUMO. We identify a nucleosome‐targeting motif within the RNF4 RING domain that can bind DNA and thereby enables RNF4 to selectively ubiquitinate nucleosomal histones. Furthermore, RNF4 nucleosome‐targeting is crucially required for the repair of TRF2‐depleted dysfunctional telomeres by 53BP1‐mediated non‐homologous end joining. 相似文献
145.
Kerr Carolyn L.; Ito Yushi; Manwell Stuart E.E.; Veldhuizen Ruud A.W.; Yao Li-Juan; McCaig Lynda A.; Lewis James F. 《Journal of applied physiology》1998,85(2):676-684
The effectsof both surfactant distribution patterns and ventilation strategiesutilized after surfactant administration were assessed in lung-injuredadult rabbits. Animals received 50 mg/kg surfactant via intratrachealinstillation in volumes of either 4 or 2 ml/kg. A subset ofanimals from each treatment group was euthanized for evaluation of theexogenous surfactant distribution. The remaining animals wererandomized into one of three ventilatory groups: group1 [tidal volume(VT) of 10 ml/kg with 5 cmH2O positive end-expiratorypressure (PEEP)]; group 2 (VT of 5 ml/kg with 5 cmH2O PEEP); orgroup 3 (VT of 5 ml/kg with 9 cmH2O PEEP). Animals wereventilated and monitored for 3 h. Distribution of the surfactant wasmore uniform when it was delivered in the 4 ml/kg volume. When thedistribution of surfactant was less uniform, arterial PO2 values were greater ingroups 2 and3 compared with group1. Oxygenation differences among the differentventilation strategies were less marked in animals with the moreuniform distribution pattern of surfactant (4 ml/kg). In bothsurfactant treatment groups, a high mortality was observed with theventilation strategy used for group 3.We conclude that the distribution of exogenous surfactant affects theresponse to different ventilatory strategies in this model of acutelung injury. 相似文献
146.
By highlighting and merging the frameworks of sexual selectionenvisioned by Arnold (1994) and Murphy (1998), we discuss howsexual selection can occur in plants even though individualsdo not directly interact. We review studies on traits that influencepollen export and receipt in a variety of hermaphroditic andgynodioecious plants with the underlying premise that pollinationdynamics influences mate acquisition. Most of the studies reviewedfound that phenotypes that enhance pollen export are in harmonywith those that enhance pollen receipt suggesting that in manycases pollinator visitation rates limit both male and femalefunction. In contrast, fewer traits were under opposing selection;but when they were, the traits most often were associated withenhancing the specific aspects of a given sex function. Ourreview helps clarify and illustrate why sexual selection canbe a component of trait evolution in hermaphrodite plants. 相似文献
147.
Clay Trauernicht Brett P. Murphy Lynda D. Prior Michael J. Lawes David M. J. S. Bowman 《Ecosystems》2016,19(5):896-909
Woody plant demographics provide important insight into ecosystem state-shifts in response to changing fire regimes. In Australian tropical savannas, the switch from patchy landscape burning by Aborigines to unmanaged wildfires within the past century has been implicated in biodiversity declines including the fire-sensitive conifer, Callitris intratropica. C. intratropica commonly forms small, closed-canopy groves that exclude fire and allow recruitment of conspecifics and other fire-sensitive woody plants. C. intratropica groves provide a useful indicator of heterogeneity and fire regime change, but the mechanisms driving the species’ persistence and decline remain poorly understood. We examined the hypothesis that C. intratropica population stability depends upon a regime of frequent, low-intensity fires maintained by Aboriginal management. We combined integral projection models of C. intratropica population behaviour with an environmental state change matrix to examine how vital rates, grove dynamics and the frequency of high- and low-intensity fires contribute to population stability. Closed-canopy C. intratropica groves contributed disproportionately to population growth by promoting recruitment, whereas singleton trees accounted for a larger proportion of adult mortality. Our patch-based population model predicted population declines under current fire frequencies and that the recruitment of new groves plays a critical role in the species’ persistence. Our results also indicated that reducing fire intensity, a key outcome of Aboriginal burning, leads to C. intratropica population persistence even at high fire frequencies. These findings provide insight into the relationship between ecosystem composition and human–fire interactions and the role of fire management in sustaining the mosaics that comprise ‘natural’ systems. 相似文献
148.
149.
Commentary: When does understanding phenotypic evolution require identification of the underlying genes? 下载免费PDF全文
Mark D. Rausher Lynda F. Delph 《Evolution; international journal of organic evolution》2015,69(7):1655-1664
Adaptive evolution is fundamentally a genetic process. Over the past three decades, characterizing the genes underlying adaptive phenotypic change has revealed many important aspects of evolutionary change. At the same time, natural selection is often fundamentally an ecological process that can often be studied without identifying the genes underlying the variation on which it acts. This duality has given rise to disagreement about whether, and under what circumstances, it is necessary to identify specific genes associated with phenotypic change. This issue is of practical concern, especially for researchers who study nonmodel organisms, because of the often enormous cost and labor required to “go for the genes.” We here consider a number of situations and questions commonly addressed by researchers. Our conclusion is that although gene identification can be crucial for answering some questions, there are others for which definitive answers can be obtained without finding underlying genes. It should thus not be assumed that considerations of “empirical completeness” dictate that gene identification is always desirable. 相似文献
150.