全文获取类型
收费全文 | 4315篇 |
免费 | 196篇 |
出版年
2024年 | 5篇 |
2023年 | 48篇 |
2022年 | 70篇 |
2021年 | 142篇 |
2020年 | 126篇 |
2019年 | 153篇 |
2018年 | 172篇 |
2017年 | 150篇 |
2016年 | 203篇 |
2015年 | 314篇 |
2014年 | 282篇 |
2013年 | 322篇 |
2012年 | 376篇 |
2011年 | 339篇 |
2010年 | 204篇 |
2009年 | 166篇 |
2008年 | 239篇 |
2007年 | 212篇 |
2006年 | 207篇 |
2005年 | 159篇 |
2004年 | 180篇 |
2003年 | 136篇 |
2002年 | 109篇 |
2001年 | 22篇 |
2000年 | 22篇 |
1999年 | 19篇 |
1998年 | 20篇 |
1997年 | 9篇 |
1996年 | 18篇 |
1995年 | 7篇 |
1994年 | 7篇 |
1993年 | 2篇 |
1992年 | 8篇 |
1991年 | 2篇 |
1989年 | 8篇 |
1988年 | 3篇 |
1986年 | 3篇 |
1985年 | 3篇 |
1984年 | 10篇 |
1983年 | 3篇 |
1982年 | 5篇 |
1981年 | 3篇 |
1980年 | 2篇 |
1979年 | 4篇 |
1978年 | 4篇 |
1975年 | 2篇 |
1965年 | 1篇 |
1964年 | 1篇 |
1961年 | 1篇 |
1951年 | 1篇 |
排序方式: 共有4511条查询结果,搜索用时 203 毫秒
31.
Pablo Ferreira das Chagas Mirella Baroni María Sol Brassesco Luiz Gonzaga Tone 《The journal of gene medicine》2020,22(1)
Musashi comprises an evolutionarily conserved family of RNA‐binding proteins (RBP) that regulate cell fate decisions during embryonic development and play key roles in the maintenance of self‐renewal and differentiation of stem cells and adult tissues. More recently, several studies have shown that any dysregulation of MSI1 and MSI2 can lead to cellular dysfunctions promoting tissue instability and tumorigenesis. Moreover, several reports have characterized many molecular interactions between members of the Musashi family with ligands and receptors of the signaling pathways responsible for controlling normal embryonic development: Notch, Transforming Growth Factor Beta (TGF‐β), Wingless (Wnt) and Hedgehog Signaling (Hh); all of which, when altered, are strongly associated with cancer onset and progression, especially in pediatric tumors. In this context, the present review aims to compile possible cross‐talks between Musashi proteins and members of the above cited molecular pathways for which dysregulation plays important roles during carcinogenesis and may be modulated by these RBP. 相似文献
32.
Nayara F. C. Castro Luiz R. Falleiros‐Júnior Mariele I. Zuco Ana P. S. Perez Sebastio R. Taboga Fernanda C. A. Santos Patrícia S. L. Vilamaior 《Cell biology international》2020,44(7):1467-1480
Prenatal and neonatal exposure to estrogenic compounds, such as ethinylestradiol (EE), promotes a variety of developmental disorders, including malformations and alterations in the morphology of glands, such as the prostate gland. Therefore, the aim of this study was to evaluate the morphological effects of neonatal exposure to EE on prostatic tissue and on the identification and quantification of gerbil gland macrophages in adult and senile Mongolian gerbils. The animals were exposed to EE (10 μg/kg/day) and to the vehicle, mineral oil (100 μL) (control group) during the first 10 days of postnatal life (lactation period). Adult gerbils were euthanized at 120 days and senile gerbils at 12 months of age. Our findings permitted verification of the presence of areas with proliferative foci in the prostate glandular portions in the adult and senile animals exposed to EE. There was also an increase in macrophages in the prostate tissue of adult and senile gerbils; these cell types alter the stromal microenvironment and possibly modify the interactions between the epithelium and stroma. Neonatal exposure to EE changes the pattern of prostatic development, leading to alterations in the arrangement of cells, including macrophages, and may be related to the onset of proliferative disorders in the prostate of adult gerbils and during aging. 相似文献
33.
Santos Valdenice F. Costa Maria S. Campina Fábia F. Rodrigues Renato R. Santos Ana L. E. Pereira Felipe M. Batista Karla L. R. Silva Rafael C. Pereira Raquel O. Rocha Bruno A. M. Coutinho Henrique D. M. Teixeira Claudener S. 《Probiotics and antimicrobial proteins》2020,12(1):82-90
Probiotics and Antimicrobial Proteins - The use of natural products together with standard antimicrobial drugs has recently received more attention as a strategy to combat infectious diseases... 相似文献
34.
35.
36.
Ana C.A. Casarotti Daniela Teixeira Ieda M. Longo-Maugeri Mayari E. Ishimura Maria E.R. Coste Henrique T. Bianco Flavio T. Moreira Amanda F. Bacchin Maria C. Izar Iran Gonalves Jr Adriano Caixeta Gilberto Szarf Ibraim M. Pinto Francisco A. Fonseca 《Bioscience reports》2021,41(2)
Despite early reperfusion, patients with ST segment elevation myocardial infarction (STEMI) may present large myocardial necrosis and significant impairment of ventricular function. The present study aimed to evaluate the role of subtypes of B lymphocytes and related cytokines in the infarcted mass and left ventricular ejection fraction obtained by cardiac magnetic resonance imaging performed after 30 days of STEMI. This prospective study included 120 subjects with STEMI submitted to pharmacoinvasive strategy. Blood samples were collected in subjects in the first (D1) and 30th (D30) days post STEMI. The amount of CD11b+ B1 lymphocytes (cells/ml) at D1 were related to the infarcted mass (rho = 0.43; P=0.033), measured by cardiac MRI at D30. These B1 cells were associated with CD4+ T lymphocytes at D1 and D30, while B2 classic lymphocytes at day 30 were related to left ventricular ejection fraction (LVEF). Higher titers of circulating IL-4 and IL-10 were observed at D30 versus D1 (P=0.013 and P<0.001, respectively). Titers of IL-6 at D1 were associated with infarcted mass (rho = 0.41, P<0.001) and inversely related to LVEF (rho = −0.38, P<0.001). After multiple linear regression analysis, high-sensitivity troponin T and IL-6 collected at day 1 were independent predictors of infarcted mass and, at day 30, only HDL-C. Regarding LVEF, high-sensitivity troponin T and high-sensitivity C-reactive protein were independent predictors at day 1, and B2 classic lymphocytes, at day 30. In subjects with STEMI, despite early reperfusion, the amount of infarcted mass and ventricular performance were related to inflammatory responses triggered by circulating B lymphocytes. 相似文献
37.
Seminotti Bianca Roginski Ana Cristina Zanatta Ângela Amaral Alexandre Umpierrez Fernandes Thabata Spannenberger Kaleb Pinto da Silva Lucas Henrique Rodrigues Ribeiro Rafael Teixeira Leipnitz Guilhian Wajner Moacir 《Journal of bioenergetics and biomembranes》2021,53(5):525-539
Journal of Bioenergetics and Biomembranes - S-adenosylmethionine (AdoMet) predominantly accumulates in tissues and biological fluids of patients affected by liver dysmethylating diseases,... 相似文献
38.
Morales-Gamba Ruben Dario de Araújo Maria Lúcia Góes Barcellos Jose Fernando Marcon Jaydione Luiz 《Environmental Biology of Fishes》2021,104(12):1665-1672
Environmental Biology of Fishes - This study evaluated how the plasma steroid hormones testosterone (T) and 17β-estradiol (E2) are related to follicular development in regenerating females of... 相似文献
39.
da Silva Fernando Henrique Alves de Morais Patrícia Lígia Dantas da Silva Dias Nildo de Sousa Nunes Glauber Henrique de Morais Marciana Bizerra Melo Marlenildo Ferreira de Albuquerque Nascimento Maria Tereza 《Journal of Plant Growth Regulation》2021,40(3):1298-1314
Journal of Plant Growth Regulation - This study evaluated the effect of saline water irrigation (4.5 dS m−1) on growth, gas exchange and mineral nutrient content in eight melon accessions and... 相似文献
40.
de Sousa Sylvia Morais de Oliveira Christiane Abreu Andrade Daniele Luiz de Carvalho Chainheny Gomes Ribeiro Vitória Palhares Pastina Maria Marta Marriel Ivanildo Evódio de Paula Lana Ubiraci Gomes Gomes Eliane Aparecida 《Journal of Plant Growth Regulation》2021,40(2):867-877
Journal of Plant Growth Regulation - The rising demand for agricultural commodities in developing countries has put increasing pressure on land resources for higher yields, with associated growth... 相似文献