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131.
Alice Toso Simona Schifano Charlotte Oxborough Krista McGrath Luke Spindler Anabela Castro Lucy Evangelista Vanessa Filipe Maria José Gonçalves Antonio Marques Inês Mendes da Silva Raquel Santos Maria João Valente Iona McCleery Michelle Alexander 《American journal of physical anthropology》2021,176(2):208-222
132.
Jaramillo L. Santos D. Guedes D. Dias D. Borges E. Pereira N. 《Applied Biochemistry and Microbiology》2021,57(4):452-457
Applied Biochemistry and Microbiology - Lactic acid has a privileged position in the family of carboxylic substances due to its several applications, including the production of biodegradable... 相似文献
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135.
Petsch Danielle Katharine Ribas Luiz Guilherme dos Santos Mantovano Tatiane Pulzatto Mikaela Marques Alves Andreia Teixeira Pinha Gisele Daiane Thomaz Sidinei Magela 《Hydrobiologia》2021,848(9):2319-2330
Hydrobiologia - Biological invasions and climate change are important drivers of biodiversity loss. In freshwater ecosystems, golden and zebra mussels are two highly aggressive invasive species... 相似文献
136.
Ulrich Dobramysl Iris Katharina Jarsch Yoshiko Inoue Hanae Shimo Benjamin Richier Jonathan R. Gadsby Julia Mason Alicja Szaapak Pantelis Savvas Ioannou Guilherme Pereira Correia Astrid Walrant Richard Butler Edouard Hannezo Benjamin D. Simons Jennifer L. Gallop 《The Journal of cell biology》2021,220(4)
Assemblies of actin and its regulators underlie the dynamic morphology of all eukaryotic cells. To understand how actin regulatory proteins work together to generate actin-rich structures such as filopodia, we analyzed the localization of diverse actin regulators within filopodia in Drosophila embryos and in a complementary in vitro system of filopodia-like structures (FLSs). We found that the composition of the regulatory protein complex where actin is incorporated (the filopodial tip complex) is remarkably heterogeneous both in vivo and in vitro. Our data reveal that different pairs of proteins correlate with each other and with actin bundle length, suggesting the presence of functional subcomplexes. This is consistent with a theoretical framework where three or more redundant subcomplexes join the tip complex stochastically, with any two being sufficient to drive filopodia formation. We provide an explanation for the observed heterogeneity and suggest that a mechanism based on multiple components allows stereotypical filopodial dynamics to arise from diverse upstream signaling pathways. 相似文献
137.
Olívia Moraes Ruberti Andressa Silva Sousa Laís Rosa Viana Moiss Felipe Pereira Gomes Alessandra Medeiros Maria Cristina Cintra Gomes Marcondes Luciano de Figueiredo Borges Carlos Cesar Crestani Cristiano Mostarda Telma Ftima da Cunha Moraes Rafael Renatino Canevarolo Maria Andreia Delbin Bruno Rodrigues 《Journal of cellular physiology》2021,236(2):1105-1115
This study aimed to evaluate the impact of aerobic training (AT) on autonomic, cardiometabolic, ubiquitin‐proteasome activity, and inflammatory changes evoked by myocardial infarction (MI) in ovariectomized rats. Female Wistar rats were ovariectomized and divided into four groups: sedentary + sham (SS), sedentary + MI (SI), AT + sham surgery (TS), AT + MI (TI). AT was performed on a treadmill for 8 weeks before MI. Infarcted rats previously subjected to AT presented improved physical capacity, increased interleukin‐10, and decreased pro‐inflammatory cytokines. Metabolomic analysis identified and quantified 62 metabolites, 9 were considered significant by the Vip Score. SS, SI, and TS groups presented distinct metabolic profiles; however, TI could not be distinguished from the SS group. MI dramatically increased levels of dimethylamine, and AT prevented this response. Our findings suggest that AT may be useful in preventing the negative changes in functional, inflammatory, and metabolic parameters related to MI in ovariectomized rats. 相似文献
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139.
Santos Francisco Denis Souza Maubrigades Lucas Reichert Gonçalves Vitória Sequeira Franz Helen Cabaldi Rodrigues Paulo Ricardo Centeno Cunha Rodrigo Casquero Leite Fábio Pereira Leivas 《Probiotics and antimicrobial proteins》2021,13(3):655-663
Probiotics and Antimicrobial Proteins - Bacterial spores of the genus Bacillus are being evaluated as adjuvant molecules capable of improving the immune response to vaccines. In this study, we... 相似文献
140.
Liliane Bezerra de Lima Wliana Alves Viturino da Silva Ewelyn Cintya Felipe dos Santos Janaína Carla Barbosa Machado Thamara Figueiredo Procópio Maiara Celine de Moura Thiago Henrique Napoleão Magda Rhayanny Assunção Ferreira Luiz Alberto Lira Soares 《化学与生物多样性》2021,18(12):e2100538
The aim of this study was to evaluate the phytochemical composition, antioxidant, and antimicrobial potential of crude extract and fractions of Punica granatum leaves. The extract was produced by turbo extraction, after which hexanic, ethyl acetate, and aqueous fractions were obtained by partitioning. The chemical analyses were performed by thin layer chromatography and high-performance liquid chromatography, and the antioxidant activities were assayed by DPPH. and ABTS.+. Minimal inhibitory and bactericidal concentrations (MIC/MBC) were applied to twenty-two bacteria. Most strains susceptible to extract/fractions and resistant to antibiotics were selected, and ampicillin, azithromycin, ciprofloxacin, and gentamicin were associated with the ethyl acetate fraction (EAF) against multidrug-resistant strains in modulatory and checkboard models. The data from chromatographic analyses showed flavonoids and tannins in the extract, as well as the enrichment of EAF in phenols, mainly flavonoids. The flavonoids were connected to the electron transfer activity demonstrated in the DPPH. and ABTS.+ assays. Gram-positive strains are more susceptible to EAF. The subinhibitory concentrations of P. granatum enhanced the antimicrobial activity of the agents and reduced the EAF individual MIC, and the combination of EAF and antibiotics demonstrated a synergistic effect. These results present a promising approach for developing a therapy in which antioxidant extracts and fractions can be used in combination with antibiotics. 相似文献