排序方式: 共有137条查询结果,搜索用时 750 毫秒
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Ludovico Giulio 《Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology》1962,45(4):376-389
Zusammenfassung Es wird die Bedeutung von optischen Reizen in der Anfangsphase des Beutefangs bei Araneus diadematus
Clerck nachgewiesen. Optische und vibratorische Reize tragen beide, nach der Reizsummenregel, zur Auslösung der Beutefangreaktion bei. Die Taxiskomponenten der optischen bzw. vibratorischen Reize schließen sich jedoch in ihrem Einfluß auf die Endrichtung der motorischen Reaktion von Araneus gegenseitig aus; sie wirken kompetitiv, und das Überwiegen der einen oder anderen Taxiskomponente hängt von den topographischen Eigenschaften der Reize ab. 相似文献
133.
Shima Safaiyan Simon Besson-Girard Tuğberk Kaya Ludovico Cantuti-Castelvetri Lu Liu Hao Ji Martina Schifferer Garyfallia Gouna Fumere Usifo Nirmal Kannaiyan Dirk Fitzner Xianyuan Xiang Moritz J. Rossner Matthias Brendel Ozgun Gokce Mikael Simons 《Neuron》2021,109(7):1100-1117.e10
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Helicobacter pylori is a major chronic health problem, infecting more than half of the population worldwide. H. pylori infection is linked with various clinical complications ranging from gastritis to gastric cancer. The resolution of gastritis and peptic ulcer appears to be linked with the eradication of H. pylori. However, resistance to antibiotics and eradication failure rates are reaching alarmingly high levels. This calls for urgent action in finding alternate methods for H. pylori eradication. Here, we discuss the recently identified mechanism of H. pylori known as cholesterol glucosylation, mediated by the enzyme cholesterol-α-glucosyltransferase, encoded by the gene cgt. Cholesterol glucosylation serves several functions that include promoting immune evasion, enhancing antibiotic resistance, maintaining the native helical morphology, and supporting functions of prominent virulence factors such as CagA and VacA. Consequently, strategies aiming at inhibition of the cholesterol glucosylation process have the potential to attenuate the potency of H. pylori infection and abrogate H. pylori immune evasion capabilities. Knockout of H. pylori cgt results in unsuccessful colonization and elimination by the host immune responses. Moreover, blocking cholesterol glucosylation can reverse antibiotic susceptibility in H. pylori. In this work, we review the main roles of cholesterol glucosylation in H. pylori and evaluate whether this mechanism can be targeted for the development of alternate methods for eradication of H. pylori infection. 相似文献
136.
Jennifer D. Whitesell Adam Liska Ludovico Coletta Karla E. Hirokawa Phillip Bohn Ali Williford Peter A. Groblewski Nile Graddis Leonard Kuan Joseph E. Knox Anh Ho Wayne Wakeman Philip R. Nicovich Thuc Nghi Nguyen Cindy T.J. van Velthoven Emma Garren Olivia Fong Maitham Naeemi Julie A. Harris 《Neuron》2021,109(3):545-559.e8
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137.
Alberto Conforti Ludovico Medolago-Albani Luciano Alessio 《Virchows Archiv. B, Cell pathology including molecular pathology》1976,22(1):143-149
The ultrastructural changes of human leukemic cell nuclei have been investigated.
Particular attention is paid to the alteration of the nuclear envelope and its constituents, i.e., the pores and the Zonula
Nucleum Limitans which appear constantly involved in these pathologic processes. An alteration of the relationships between
the components of the nuclear envelope and the chromatin itself may be responsible for the appearance of the most nuclear
changes. 相似文献