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Emerging drug resistance in Salmonella coupled with the recent poor success rate of antibiotic discovery programs of the pharmaceutical industry is a cause for significant concern. It has forced the scientific community to look for alternative new classes of antimicrobial compounds. In this context, combinations of antimicrobial peptides (AMPs) and conventional antibiotics have gained interest owing to their versatile applications. The present study was therefore planned to evaluate the synergistic effects, if any, of cryptdin-2, a mouse Paneth cell alpha-defensin, in combination with four different antibiotics i.e. ciprofloxacin, ceftriaxone, cefotaxime and chloramphenicol, which are conventionally used against Salmonella. Minimum bactericidal concentrations of the selected antimicrobial agents were determined by micro and macro broth dilution assays. In-vitro synergy between the agents was evaluated by fractional bactericidal concentration index (checkerboard test) and time-kill assay. Cryptdin-2-ciprofloxacin, cryptdin-2-ceftriaxone and cryptdin-2-cefotaxime combinations were found synergistic as evident by in vitro assays. This synergism provides an additional therapeutic choice by allowing the use of conventional antibiotics in conjunction with AMPs against MDR Salmonella. 相似文献
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Raf Brouns Bart Marescau Ilse Possemiers Rishi Sheorajpanday Peter P. De Deyn 《Neurochemical research》2009,34(9):1642-1649
We hypothesise that asymmetric and symmetric dimethylarginine (ADMA, SDMA) are released in cerebrospinal fluid (CSF) due to
ischemia-induced proteolysis and that CSF dimethylarginines are related to stroke severity. ADMA and SDMA were measured in
CSF of 88 patients with ischemic stroke or TIA within 24 h after stroke onset (mean 8.6 h) and in 24 controls. Stroke severity
was assessed by the National Institutes of Health Stroke Scale (NIHSS) score at admission. Outcome was evaluated by institutionalization
due to stroke and the modified Rankin scale. Dimethylarginine levels were higher in patients with stroke than in TIA patients,
who had higher levels than controls and correlated with the NIHSS. Logistic regression analysis confirmed that dimethylarginines
were independently associated with stroke severity. The SDMA/ADMA ratio did not differ significantly between controls and
stroke patients. CSF dimethylarginine levels are increased in hyperacute ischemic stroke and are associated with stroke severity.
R. Brouns is a research assistant of the Fund for Scientific research Flanders (FWO-Vlaanderen). 相似文献
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Christopher D. Wiley Rishi Sharma Sonnet S. Davis Jose Alberto Lopez-Dominguez Kylie P. Mitchell Samantha Wiley Fatouma Alimirah Dong Eun Kim Therese Payne Andrew Rosko Eliezer Aimontche Sharvari M. Deshpande Francesco Neri Chisaka Kuehnemann Marco Demaria Arvind Ramanathan Judith Campisi 《Cell metabolism》2021,33(6):1124-1136.e5
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