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91.
Chattopadhyay MB Mukherjee S Kulkarni I Vijayan V Doloi M Kanjilal N Chatterjee M 《Cancer cell international》2005,5(1):16
Combined effect of vanadium and beta-carotene on rat liver DNA-chain break and Proton induced X-ray emission (PIXE) analysis
was studied during a necrogenic dose (200 mg/kg of body weight) of Diethyl Nitrosamine (DENA) induced rat liver carcinogenesis.
Morphological and histopathological changes were observed as an end point biomarker. Supplementation of vanadium (0.5 ppm
ad libitum) in drinking water and beta-carotene in the basal diet (120 mg/Kg of body weight) were performed four weeks before DENA treatment
and continued till the end of the experiment (16 weeks). PIXE analysis revealed the restoration of near normal value of zinc,
copper, and iron, which were substantially altered when compared to carcinogen treated groups. Supplementation of both vanadium
and beta-carotene four weeks before DENA injection was found to offer significant (64.73%, P < 0.001) protection against generation
of single-strand breaks when compared with the carcinogen control counter parts. A significant stabilization of hepatic architecture
of the cells was observed as compared to carcinogen control in vanadium plus beta-carotene treated group. This study thus
suggests that vanadium, a prooxidant but potential therapeutic agent yield safe and effective pharmacological formulation
with beta-carotene, an antioxidant, in the inhibition of experimental rat hepatocarcinogenesis. 相似文献
92.
Epling-Burnette PK Zhong B Bai F Jiang K Bailey RD Garcia R Jove R Djeu JY Loughran TP Wei S 《Journal of immunology (Baltimore, Md. : 1950)》2001,166(12):7486-7495
Polymorphonuclear neutrophils (PMN) are phagocytic cells constitutively programmed for apoptotic cell death. Exposure to GM-CSF delays apoptosis as measured by annexin-V staining and cell morphological change. We found that STAT5B, STAT1, and STAT3 DNA-binding activity was induced by GM-CSF. We also detected activation of the phosphatidylinositol 3-kinase (PI 3-kinase) pathway after GM-CSF treatment which was inhibited by treatment with the PI 3-kinase inhibitors, wortmannin and LY294002. We investigated whether STAT or PI 3-kinase activity was necessary for the pro-survival response of GM-CSF in PMN. Exposure of PMN to GM-CSF in the presence of either AG-490, antisense STAT3 oligonucleotides, or wortmannin resulted in a partial inhibition of GM-CSF-mediated pro-survival activity. GM-CSF induced a time-dependent increase in the mRNA and protein expression of the anti-apoptotic Bcl-2-family protein, Mcl-1. We examined the hypothesis that Janus kinase/STAT and PI 3-kinase regulation of Mcl-1 contributed to GM-CSF-delayed apoptosis. Using either AG-490 or wortmannin alone, we observed a dose-dependent inhibition of GM-CSF-induced Mcl-1 expression. Using suboptimal doses of AG-490 and wortmannin, we found that both drugs together had an additive effect on delayed apoptosis and Mcl-1 expression. These data suggest that cooperative regulation of Mcl-1 by the Janus kinase/STAT and PI 3-kinase pathways contribute to GM-CSF-delayed apoptosis. 相似文献
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Michael F. E. Loughran 《Acta theriologica》2006,51(3):233-242
The social organisation of a population ofMicrotus agrestis (Linnaeus, 1761) was studied by live trapping and radiotracking in southern England. Radiotracking revealed significant differences
in both female home ranges and core areas with breeding condition. Lactating females had the smallest home ranges and core
areas, and pregnant females the largest. There were no significant differences in female home range and core areas during
the breeding season or between years despite different densities. Females were only territorial whilst lactating during which
time their core areas were small. There were some overlaps of core areas among females at the beginning of the breeding season
which are thought to be due to familiarity or kin associations. Associations between females were short-lived, lasting approximately
one breeding event. As the breeding season progressed core areas became distinct suggesting a change to a territorial system
although densities were low and most females were lactating. Patterns of social organisation among females were similar in
both 1995 and 1996. Mean nearest neighbour distances tended to increase as the breeding season progressed and were uncorrelated
with density. 相似文献