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191.
Thymoquinone protects against 5-Fluorouracil-induced mucositis by NF-κβ and HIF-1 mechanisms in mice
Fatemeh Madani Sohrab Kazemi Fatemeh Shirafkan Mandana Lotfi Seyed M. Hosseini Ali A. Moghadamnia 《Journal of biochemical and molecular toxicology》2023,37(9):e23405
Mucositis is among the most common side effects of 5-Fluorouracil (5-FU) and other cancer therapeutic drugs. Thymoquinone (TQ), a bioactive constituent extracted from Nigella sativa, has antioxidant and anti-inflammatory properties and can modify acute gastrointestinal injury. To investigate the effects of TQ on mucositis induced by 5-FU, studied animals were divided into four groups: control, 5-FU unit dose (300 mg/kg) to cause oral and intestinal mucositis (OM and IM), TQ (2.5 mg/kg) and TQ (2.5 mg/kg) plus 5-FU. Due to The molecular mechanisms, it was confirmed that the expression of NF-κβ and HIF-1 increases in OM. The serum levels of malondialdehyde (MDA), catalase (CAT), and superoxide dismutase (SOD), as well as pathological parameters, were assessed. Based on our results, the nuclear factor-kappa β gene expression in the tongue was downregulated significantly in the 5-FU + TQ compared to the 5-FU. TQ treatment can diminish MDA, and a reduction in oxidative stress was shown. TQ could also reduce the severity of tissue destruction and damaging effects induced by 5-FU on the tongue and intestine. We also observed lower villus length and width in the intestine of the 5-FU group compared to the control group. According to our research's pathological, biochemical, and molecular results, treatment with TQ as an anti-inflammatory and antioxidant compound may be the potential to improve and treat 5-FU-induced OM and IM, and TQ could be used against cancer treatment drugs and exhibit fewer adverse effects. 相似文献
192.
The nucleotide sequence data reported in this paper have been submitted to the GenBank nucleotide sequence database and have been assigned the accession number M96942. 相似文献
193.
Assessment of the eutrophication of Al Massira reservoir (Morocco) by means of a survey of the biogeochemical balance of phosphate 总被引:3,自引:1,他引:2
The biogeochemical balance of phosphate was studied in Al Massira reservoir (Morocco) from February 1991 to end January 1992. The study concerned P-supplies and losses by the Oum errbia river, sedimentation rate and water-sediment exchange.Supply and loss of phosphate were calculated from samples collected every 48 hours. Phosphate sedimentation rate was measured with sediment traps. The assessment of phosphate release at the water-sediment interface during either low oxic or anoxic conditions was made in situ with a benthic chamber.The results showed that phosphate input was higher than phosphate output resulting in a progressive increase of the internal phosphorus stock. The sedimentation flux ranged between 9 and 19 mg m–2 d–1 of P. Release of phosphate depended on the oxygen concentrations in the water.We suggest that a drastic control of phosphate input into the water must be achieved through a programme of dephosphorylation of the tributaries to avoid accumulation of calcium-bound phosphate which may become a source of upward release of bioavailable phosphate.Further investigations of this flux should be carried out to check the quantitative influence on phytoplankton community dynamics. 相似文献
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Lotfi Rabaoui Randa Mejri Sabiha Tlig-Zouari Lilia Bahri Oum Kalthoum Ben Hassine Costas S. Tsigenopoulos 《Hydrobiologia》2011,678(1):99-111
The Mediterranean fan mussel Pinna nobilis is an endangered invertebrate due to overexploitation and habitat deterioration. In this species, two distinctive morphs,
the “combed” and “straight and wide” forms, have been recorded and it is not known whether this morphometric variability is
attributed to genetic or environmental factors. In this study, we used mitochondrial COI sequences to describe the genetic
variability of five Pinna nobilis populations sampled along the northern, eastern, and southern Tunisian coastline, and to examine whether there is a genetic
differentiation between the two forms of this species. DNA sequences of 675 bp from the mitochondrial COI gene have revealed
10 different haplotypes among 49 examined specimens. Haplotype diversity was high, ranging between 0.40441 and 0.80952, and
showed a decreasing North-East gradient, which seems to be explained by the hydrogeography of the study area. The mitochondrial
COI marker did not suggest a genetic distinctiveness between the two Pinna nobilis shell forms, “combed” and “straight and wide”. Although the morphometric plasticity of the fan mussel could be due to the
influence of environmental factors, further genetic studies using nuclear markers are envisaged to investigate whether this
differentiation is associated to gene flow restrictions. 相似文献
197.
Akram Davoodi Ramin Lotfi Seyed Hamidreza Mortazavi Ali Gorgin Karaji Alireza Rezaiemanesh Farhad Salari 《Reports of Biochemistry & Molecular Biology》2021,9(4):399
Background:Retinoic acid (RA) plays a key role in naïve T cell differentiation into FOXP3+ Treg cell in the respiratory airways. The present study aims to investigate RA and Treg-related cytokine serum levels, salivary IgA levels, FOXP3 and IL-4 gene expression, and the relationships between RA serum levels and Treg-related cytokines in allergic rhinitis (AR) patients and healthy controls.Methods:Salivary IgA and serum IgE, RA, IL-10, and TGF-β concentrations were measured by ELISA in 37 AR patients and 30 age- and sex-matched healthy controls.Results:IL-10 and TGF-β concentrations were significantly less in AR patients than in healthy controls (p< 0.01 and P< 0.0001, respectively). Salivary IgA was significantly greater in patients than in controls (p< 0.05). RA was not significantly different between patients and controls (p> 0.05); however, a significant positive correlation was found between serum RA and both IL-10 and TGF-β in AR patients.Conclusion:Our data suggest that RA may influence AR risk via affecting the TGF-β and IL-10 production.Key Words: Allergic Rhinitis, Interleukin-10, Obesity, Retinoic Acid, Transforming Growth Factor-β 相似文献
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Temim Deli Souad Guizeni Lotfi Ben Abdallah Khaled Said Noureddine Chatti 《Marine Biology Research》2020,16(4):280-298
ABSTRACT This investigation aims at assessing patterns of spatial genetic structure of the teleost fish Sardina pilchardus across the Siculo-Tunisian Strait (a well-known discontinuous biogeographic area) and delineating putative genetic stocks within the species. For this purpose, a total of 180 specimens, collected from 11 locations stretching across the western and eastern Mediterranean coasts of Tunisia, were analysed genetically by means of 18 nuclear allozyme loci. The outcome of this study revealed strong genetic differentiation among populations, with the marked genetic distinctiveness of the central Tunisian population at Mahdia. Despite the delineation of seven well-defined genetic groups, no significant correlation was found between genetic and geographic distances. Besides, the recorded population subdivision did not align with biogeographic boundaries, suggesting the presence of chaotic genetic patchiness. Recent genetic bottlenecks were evidenced in S. pilchardus populations. Patchy migration patterns were recorded among the examined pairs of sardine populations. Among the recorded 16 polymorphic loci, GPI-2 and SOD appeared to be subject to natural selection. Patterns of population genetic differentiation and structuring were not found to be driven by outlier loci that appeared to be under selection. Furthermore, the detected neutral GPI-1 locus was found to be responsible for most of the genetic variation among identified genetic clusters. Hence, natural selection cannot cause the detected genetic heterogeneity among sardine samples. Different explanations to the origin of chaotic genetic patterns, observed within S. pilchardus, were discussed. 相似文献
200.
Marie Mahler Lotfi Ferhat Angela Gillian Yezekiel Ben-Ari Alfonso Represa 《Cell communication & adhesion》1996,4(3):175-186
Tenascin-C is an extracellular matrix glycoprotein with trophic and repulsive properties, involved in migratory processes in CNS. Previous reports demonstrated that this molecule is produced and secreted by astrocytes. Preliminary data on fibroblasts and astrocytes have suggested that bFGF may modulate tenascin-C expression. bFGF is a mitogenic growth factor, involved in cell differentiation and neovascularization. In the present study, we ex amined whether bFGF modulates the expression of tenascin-C in hippocampal astrocytes from newborn rats. Our results suggest that bFGF increases the production of tenascin-C by cultured hippocampal astrocytes. We found that both tenascin-C mRNA and protein immunoreactivity were increased after bFGF treatment. Our results also demonstrated that tenas cin-C polypeptides were secreted into the extracellular medium. In agreement with previous studies, we suggest that secreted tenascin-C is mainly the high molecular weight form. In addition, our results suggest that a cleavage of the high molecular weight form may occur in the extracellular medium causing production of proteolytic fragments, that may modify the biological properties of tenascin-C. The present results may be relevant to the understanding of lesion scarring and regeneration process. 相似文献