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51.
We examined the relationship between subglottic pressure (P), flow (V), and thyroarytenoid (TA) muscle activity in six anesthetized tracheostomized dogs while a constant flow (0.05-1.2 l/s) of warmed humidified air was passed through the upper airway in an expiratory direction. The TA activity was recorded by fine bipolar wire electrodes and was reflexly altered by changes in lung volume and chest wall compression. The integrated muscle activity was expressed as a percentage of a maximal peak integrated TA activity (%max). In the absence of TA activity the pressure-flow relationship was alinear and could be described by a power function. Log-log P-V plots at varying levels of TA activity were linear, with a slope a of 1.84 +/- 0.07 (SD). When TA activity increased, laryngeal resistance increased exponentially. An effective hydraulic diameter was calculated for increments in %max TA and decreased linearly with %max TA. In three dogs the glottic diameter was computed from glottic area measured by fiber-optic laryngoscopy, and it also decreased linearly as TA increased. Sectioning of the external motor branch of the superior laryngeal nerve to the cricothyroid muscle demonstrated no consistent effect on laryngeal resistance over a range of TA activity. The results indicate that laryngeal dimensions decrease linearly with TA activity. However, the P-V relationship of the larynx may be described by a power function, with a single exponent consistent with an orifice flow regimen. Spontaneous activity of the cricothyroid muscle does not measurably influence this relationship. 相似文献
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Displacements of the rib cage are determined by the intrinsic passive properties of the rib cage, rib cage musculature, pleural and abdominal pressures, and the diaphragm. The diaphragm's mechanical actions on the rib cage are inferred from a force-balance analysis in which the diaphragm is seen to cause expansion of the rib cage by pulling cephalad at its insertions on the lower ribs (insertional component) and by raising intra-abdominal pressure, which pushes outward on the diaphragm's zone of apposition to the rib cage (appositional component). Goldman and Mead suggested that the diaphragm, acting alone, could drive both the rib cage and abdomen on their passive characteristics. The force-balance analysis shows that the diaphragm's inspiratory action on the rib cage is less than predicted by Goldman and Mead, but that in the special circumstances of their experiment (low lung volumes), the appositional component is large and the rib cage can be driven close to its passive characteristics. The force-balance analysis is consistent with recent observations by other investigations and is incompatible with the model proposed by Macklem and colleagues and with the Goldman-Mead hypothesis. Experiments on three subjects produced data consistent with the force-balance analysis, showing that the inspiratory action of the diaphragm on the rib cage is greatest at low lung volumes. 相似文献
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C. Loring Brace 《American journal of physical anthropology》1981,56(4):411-429
The styles of continuing intellectual traditions can have a major effect on the way in which scientific findings are expressed. Darwin and Huxley, for all their intellectual daring followed the skeptical tactics of the Scottish Enlightenment and avoided the construction of human phylogenetic trees, even though they were aware of the evidence on which such could have been constructed. The romantic evolutionism of Haeckel, Keith, and many subsequent writers in English produced suggested phylogenies on the basis of largely hypothetical forms including Homo “alalus,” “stupidus,” and “Eoanthropus.” The structural aspects of phylogenetic schemes that derive from the French intellectual ethos, from catastrophism to cladistics and punctuated equilibria, have stressed discrete categorical entities in the tradition of Platonic essentialism and have tended to avoid a consideration of evolutionary dynamics. 相似文献
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S H Loring 《Journal of applied physiology》1992,72(4):1461-1465
The actions of several human respiratory muscles have been inferred from finite element analysis of the rib cage. The human model is based on anatomic and mechanical measurements in dogs and human cadavers. As in an earlier canine model, the external and internal (interosseous) intercostal muscles were found to cause, respectively, inspiratory and expiratory displacements of the rib cage, in agreement with the two-dimensional geometric analysis of Hamberger. When extended to three dimensions, Hamberger's analysis helps explain why muscles at the side of the rib cage produce changes in the anteroposterior diameter, whereas muscles at the front and back of the rib cage cause changes in the transverse diameter. 相似文献
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