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Adam N. Spierer Jim A. Mossman Samuel Pattillo Smith Lorin Crawford Sohini Ramachandran David M. Rand 《PLoS genetics》2021,17(3)
The winged insects of the order Diptera are colloquially named for their most recognizable phenotype: flight. These insects rely on flight for a number of important life history traits, such as dispersal, foraging, and courtship. Despite the importance of flight, relatively little is known about the genetic architecture of flight performance. Accordingly, we sought to uncover the genetic modifiers of flight using a measure of flies’ reaction and response to an abrupt drop in a vertical flight column. We conducted a genome wide association study (GWAS) using 197 of the Drosophila Genetic Reference Panel (DGRP) lines, and identified a combination of additive and marginal variants, epistatic interactions, whole genes, and enrichment across interaction networks. Egfr, a highly pleiotropic developmental gene, was among the most significant additive variants identified. We functionally validated 13 of the additive candidate genes’ (Adgf-A/Adgf-A2/CG32181, bru1, CadN, flapper (CG11073), CG15236, flippy (CG9766), CREG, Dscam4, form3, fry, Lasp/CG9692, Pde6, Snoo), and introduce a novel approach to whole gene significance screens: PEGASUS_flies. Additionally, we identified ppk23, an Acid Sensing Ion Channel (ASIC) homolog, as an important hub for epistatic interactions. We propose a model that suggests genetic modifiers of wing and muscle morphology, nervous system development and function, BMP signaling, sexually dimorphic neural wiring, and gene regulation are all important for the observed differences flight performance in a natural population. Additionally, these results represent a snapshot of the genetic modifiers affecting drop-response flight performance in Drosophila, with implications for other insects. 相似文献
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Lorin W. Roberts 《Biotechnic & histochemistry》1954,29(2):63-67
There was considerable variation between the sulfhydryl induced in vitro reduction of the oxidation-reduction indicators (2,3,5-triphenyltetrazolium chloride, 2,3-diphenyl 5-methyl tetrazolium chloride, neotetrazolium chloride, neotetrazolium phosphate-2B, blue tetrazolium, tetrazolium violet, potassium tellurite, methylene blue, and resazurin). The neotetrazolium salts and potassium tellurite showed the greatest reducing activity. The reduction of the indicators by oxidized sulfhydryl compounds in the presence of potassium cyanide closely paralleled the reduction of the sarrte indicators by reduced sulfhydryl compounds. Iodoacetamide was the most effective sulfhydryl inhibitor as demonstrated by indicator reduction. 相似文献
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Lorin W. Roberts 《The Botanical review》1969,35(3):201-250
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The sulfhydryl inhibitor N-ethyl maleimide completely inhibited the reduction of 2,3,5-triphenyltetrazolium chloride in meristematic and embryonic vascular tissues of Coleus sp. stems, Ricinus communis root tips, ungerminated Tea mays embryos, and epicotyls and coleoptiles of germinated Tea mays embryos, in a concentration of 200 mg/lit. Inhibition was reversed by the addition of cysteine or reduced glutathione (200 mg/lit) to the inhibitor medium. N-ethyl maleimide was effective also in blocking the nitro-prusside and 1-(4-chIoromercuriphenylazo)-naphthol-2 sulfhydryl staining reactions, but other substituted maleimides were ineffective in inhibiting the tetrazolium reaction in these tissues. Experiments were conducted to determine the histological pattern of sulfhydryl groups as indicated by a modification of the Bennett 1-(4-chloro-mercuriphenylazo)-naphthol-2 test and a modification of the Rap-kine nitroprusside test in certain plant tissues. A positive correlation was observed between tissues reducing the tetrazolium indicator and tissues exhibiting sulfhydryl localization as indicated by the nitroprusside reagent (trichloroacetic acid pretreated) and 1—(4— chloromercuriphenylazo)—naphthol—2. 相似文献
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