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排序方式: 共有316条查询结果,搜索用时 156 毫秒
311.
Mirko Pesce Paolo Felaco Sara Franceschelli Lorenza Speranza Alfredo Grilli Maria Anna De Lutiis Alessio Ferrone Vittorio Sirolli Mario Bonomini Mario Felaco Antonia Patruno 《Open biology》2014,4(6)
Resistance to erythropoietin (EPO) affects a significant number of anaemic patients with end-stage renal disease. Previous reports suggest that inflammation is one of the major independent predictors of EPO resistance, and the effects of EPO treatment on inflammatory mediators are not well established. The aim of this study was to investigate EPO-induced modification to gene expression in primary cultured leucocytes. Microarray experiments were performed on primed ex vivo peripheral blood mononuclear cells (PBMCs) and treated with human EPO-α. Data suggested that EPO-α modulated genes involved in cell movement and interaction in primed PBMCs. Of note, EPO-α exerts anti-inflammatory effects inhibiting the expression of pro-inflammatory cytokine IL-8 and its receptor CXCR2; by contrast, EPO-α increases expression of genes relating to promotion of inflammation encoding for IL-1β and CCL8, and induces de novo synthesis of IL-1α, CXCL1 and CXCL5 in primed cells. The reduction in MAPK p38-α activity is involved in modulating both IL-1β and IL-8 expression. Unlike the induction of MAPK, Erk1/2 activity leads to upregulation of IL-1β, but does not affect IL-8 expression and release. Furthermore, EPO-α treatment of primed cells induces the activation of caspase-1 upstream higher secretion of IL-1β, and this process is not dependent on caspase-8 activation. In conclusion, our findings highlight new potential molecules involved in EPO resistance and confirm the anti-inflammatory role for EPO, but also suggest a plausible in vivo scenario in which the positive correlation found between EPO resistance and elevated levels of some pro-inflammatory mediators is due to treatment with EPO itself. 相似文献
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313.
Lorenza Menegoni has a doctorate in Anthropology from the Graduate Faculty, The New School for Social Research, New York City. She is continuing her research in Mexico. Carmen Hendershott has a doctorate in Anthropology from the Graduate Faculty, The New School for Social Research, where she is working as a research librarian. 相似文献
314.
Alaide Domínguez-Calderón Antonia ávila-Flores Arturo Ponce Esther López-Bayghen José-Víctor Calderón-Salinas José Luis Reyes Bibiana Chávez-Munguía José Segovia Carla Angulo Leticia Ramírez Helios Gallego-Gutiérrez Lourdes Alarcón Dolores Martín-Tapia Pablo Bautista-García Lorenza González-Mariscal 《Molecular biology of the cell》2016,27(10):1581-1595
315.
Tomasi Matilde Artoni Alessio Mattei Lorenza Di Puccio Francesca 《Biomechanics and modeling in mechanobiology》2023,22(2):379-400
Biomechanics and Modeling in Mechanobiology - Noninvasive estimation of joint loads is still an open challenge in biomechanics. Although musculoskeletal modeling represents a solid resource,... 相似文献
316.
Aymen Souid Lorenza Bellani Morena Gabriele Laura Pucci Abderrazak Smaoui Chedly Abdelly Karim Ben Hamed Vincenzo Longo 《化学与生物多样性》2019,16(7)
A particular interest is nowadays given to natural antioxidants occurring in foods which can reduce the risk of several diseases through their protective effect. The genus Limonium is widely distributed in different salt regions of Tunisia and known in traditional medicine for the presence of highly effective viral and bacterial replication inhibitors. Limonium leaves have possible beneficial effects on human health for their antioxidant activities and free radical scavenging abilities. To exploit the potential of plants from extreme environments as new sources of natural antioxidants, we studied the extracts from leaves of eight Limonium species growing in extreme environments in Tunisia. Antioxidant molecules (polyphenols, flavonoids, flavonols, ascorbate, tocopherols), in vitro (DPPH, ORAC) and ex vivo antioxidant potential on human erythrocytes, antioxidant enzymes activities (superoxide dismutase, peroxidases, glutathione reductase) were evaluated to identify the species with the best antioxidant capacity. The results showed variability among the species considered in function of the environmental conditions of their natural biotopes, as for the antioxidants measured. In particular, L. vulgare from Oued Rane biotope, characterized by dryness and high temperatures, was the species with the highest enzymatic activity and antioxidant capacity, making it interesting as possible edible halophyte plant or as food complement. 相似文献