A novel approach to yard planning under vessel arrival uncertainty

Many container terminals in the world adopt the consolidated yard planning strategy, where containers to be loaded into the same vessel are stacked in groups. This has been a good strategy because when a vessel is loading, yard cranes will be stationed at these locations, and the trucks shuttle between the quay cranes and the yard cranes almost in a conveyor belt fashion. These locations are optimally chosen such that no two groups of containers are stacked in close vicinity if they are to be loaded simultaneously. However, when there is a change in vessel arrival schedule, it may cause congestion of trucks at yard locations where groups of containers in near vicinity are loading simultaneously. While the Robust Optimisation community may suggest having a robust plan—a plan that is immune to uncertainty, in this paper, we will like to find a solution that allows us to change easily when uncertainty reveals—a plan that is nimble. While the optimum solution for the nimble plan could be intractable, we explore various heuristics that enable us to find good solutions.     

Spinal macrophages resolve nociceptive hypersensitivity after peripheral injury

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Pancreatic polypeptide causes diarrhea and weight loss in obese mice but not in lean littermates

Pancreatic polypeptide was infused into obese-hyperglycemic (ob/ob) mice and lean littermates to determine its effect on weight gain. Obese mice continuously infused with 30, 60, or 100 μg/day for 7 days developed both diarrhea and weight loss in a dose dependent fashion. Lean littermates infused with 100 μg/day developed neither diarrhea nor weight loss. Light microscopic study of ileum and colon revealed no abnormalities. These studies indicate that the effects of pancreatic polypeptide are in part genetically determined since the obese and non-obese mice differ at only one gene locus.     

Gas chromatographic determination of aromatic acid metabolites of phenylalanine in brain

A method for the determination of the aromatic acid metabolites of phenylalanine in brain by gas-liquid chromatography is described. Procedures were developed for the extraction and purification of the metabolites, the preparation of their trimethylsilyl derivatives, the separation and identification of these derivatives by gas-liquid chromatography, and the quantification of the metabolites by employing the internal reference standards phenylvaleric and o-hydroxyphenylacetic acids with the detector molar response factors. The metabolites in the hyperphenylalaninemic brain were identified as the trimethylsilyl ester of phenylacetic, ester-ethers of mandelic and phenyllactic, and the ester-enol ether of the oxime of phenylpyruvic acid.     

The human multidrug resistance P-glycoprotein is inactive when its maturation is inhibited: potential for a role in cancer chemotherapy.

The human multidrug resistance P-glycoprotein (P-gp) contributes to the phenomenon of multidrug resistance during cancer and AIDS chemotherapy. A potential novel strategy to circumvent the effects of P-gp during chemotherapy is to prevent maturation of P-gp during biosynthesis so that the transporter does not reach the cell surface. Here we report that immature, core-glycosylated P-gp that is prevented from reaching the cell surface by processing mutations or by proteasome inhibitors such as lactacystin or MG-132 exhibited no detectable drug-stimulated ATPase activity. Disulfide cross-linking analysis also showed that the immature P-gp did not exhibit ATP-induced conformational changes as found in the mature enzyme. In addition, the immature P-gp was more sensitive to trypsin than the mature enzyme. These results suggest that P-gp is unlikely to be functional immediately after synthesis. These differences in the structural and enzymatic properties of the mature and core-glycosylated, immature P-gp could potentially be used during chemotherapy, and should result in the search for compounds that can specifically inhibit the maturation of P-gp.     

Post-shooting stress reactions among police officers

Post-shooting stress reactions were studied in a large police force to develop a psychological services policy and procedures in support of members of the force. Two empirical studies were conducted using a mail survey of a total of 66 members involved in shootings plus clinical interviews of a sample of these members. The results showed that members experienced most stress reactions within three days of the shooting. The average time for feeling that they were back to normal working, social, and family life was 20 weeks. There was strong support for various proposed psychological services and actions to support members involved in shootings. Recommendations were made concerning the conduct of psychological debriefings, counselling and brief therapy, the use of peer counsellors, services for affected police families, and stress training in the force.