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51.
NK cell TRAIL eliminates immature dendritic cells in vivo and limits dendritic cell vaccination efficacy 总被引:9,自引:0,他引:9
Hayakawa Y Screpanti V Yagita H Grandien A Ljunggren HG Smyth MJ Chambers BJ 《Journal of immunology (Baltimore, Md. : 1950)》2004,172(1):123-129
Recent studies have implicated a possible role for NK cells in regulating dendritic cells (DC) in vitro. In the present study, we demonstrate that immature DC are rapidly eliminated by NK cells in vivo via a pathway dependent on the TNF-related apoptosis-inducing ligand (TRAIL). Elimination of NK cells and/or neutralization of TRAIL function during immunization with immature DC loaded with nonself or tumor Ags significantly enhanced T cell responses to these Ags and Ag-specific tumor immunity. These data suggested that NK cell TRAIL might regulate responses to vaccination by controlling the survival of Ag-loaded DC. 相似文献
52.
Velloso LM Michaëlsson J Ljunggren HG Schneider G Achour A 《Journal of immunology (Baltimore, Md. : 1950)》2004,172(9):5504-5511
Lymphocytic choriomeningitis virus infection of H-2(b) mice generates a strong CD8(+) CTL response mainly directed toward three immunodominant epitopes, one of which, gp33, is presented by both H-2D(b) and H-2K(b) MHC class I molecules. This CTL response acts as a selective agent for the emergence of viral escape variants. These variants generate altered peptide ligands (APLs) that, when presented by class I MHC molecules, antagonize CTL recognition and ultimately allow the virus to evade the cellular immune response. The emergence of APLs of the gp33 epitope is particularly advantageous for LCMV, as it allows viral escape in the context of both H-2D(b) and H-2K(b) MHC class I molecules. We have determined crystal structures of three different APLs of gp33 in complex with both H-2D(b) and H-2K(b). Comparison between these APL/MHC structures and those of the index gp33 peptide/MHC reveals the structural basis for three different strategies used by LCMV viral escape mutations: 1) conformational changes in peptide and MHC residues that are potential TCR contacts, 2) impairment of APL binding to the MHC peptide binding cleft, and 3) introduction of subtle changes at the TCR/pMHC interface, such as the removal of a single hydroxyl group. 相似文献
53.
Kairemo Kalevi J. A. Ljunggren Kaj Wahlström Torsten Stigbrand Torgny Strand Sven-Erik 《Cell biochemistry and biophysics》1994,24(1-3):293-300
Tumor stroma contains much fibrin and monoclonal antifibrin antibody targeting is possible in tumors. In this study, nude
mouse human ovarian carcinoma xenograft specimens were investigated after treatment with90Y-labeled monoclonal antifibrin antibody Fab fragment or with90Y-labeled OC125-monoclonal antibody F(ab′)2 fragments. The mice received the radioimmunotherapy activity either intratumorally, intraperitoneally, or intravenously.
Beta-camera imaging (BCI) is a novel device for studying activity distribution in tissue specimens and, together with immunohistochemistry
(IHC) with OC125, antifibrin, anticarcinoembryonic antigen, anti-cytokeratin, and anti-placental alkaline phosphatase antibodies,
was used for correlation of activity distribution of tissue specimens. These results were in concordance: Antigen distribution
measured with IHC and radioactivity distribution were similar with the same antibodies, antifibrin, and OC125: However, these
antigens demonstrated rather different distribution. Tissue studies revealed that activity was concentrated also in the necrotic
tumor tissue, indicating that cell death was also caused by radiation. Differences in the tumor cell morphology were observed
using different routes of administration. With BCI, it is possible to quantitate activities in frozen sections (microdosimetry),
and these results were in concordance with absolute activities as measured by tissue sampling and well-counting. Three-dimensional
reconstruction of tissue slices combined with radioactivity distribution measured with BCI allows estimation of total absorbed
radiation dose in tumor after an appropriate dose planning. 相似文献
54.
K Ljunggren F Chiodi G Biberfeld E Norrby M Jondal E M Feny? 《Journal of immunology (Baltimore, Md. : 1950)》1988,140(2):602-605
Sera from individuals infected with human immunodeficiency virus (HIV) and HIV-related West African viruses can mediate high-titered, virus-specific antibody-dependent cellular cytotoxicity (ADCC) in all stages of infection. No cross-reactive ADCC can be detected between HIV and HIV-related West African strains LAV-2, HTLV-IV, and SBL-6669. Because these two groups of viruses have antigenically distinct envelope glycoproteins, ADCC-mediating antibodies are most likely directed against envelope antigens. For HIV-specific ADCC, this was further confirmed by using sera reacting with HIV envelope but negative for antibodies against viral core antigens. 相似文献
55.
Summary In view of the increasing need for the exact estimation of the input of nitrogen in agroecosystems, an application of the acetylene-reduction technique was developed. The technique, consisting of a plastic bag incubation system, using propane as an internal standard of the apparent volume, made it possible to carry out repeated incubations on the same plant system. The evaluated technique included studies of the diffusion of ethylene and propane in a soil column, as well as studies of the optimal substrate concentration and grade of purity of the substrate. In addition, the conversion factor between amounts of reduced acetylene as compared wtih reduced dinitrogen was determined by15N2 incubations to be 4.41. The developedin situ acetylene-reduction technique was compared with an isotope dilution method and a total nitrogen difference method. By comparing the derived total nitrogen fixation values from each with the value derived from the acetylene-reduction method; it was shown that the values differed significantly. The acetylene-reduction method gave the highest nitrogen fixation values, the isotope dilution the lowest values and the total nitrogen difference method was intermediate. No statistical significant difference existed between the two different reference crops used in the isotope dilution method. 相似文献
56.
57.
Arvidsson Rickard Söderman Maria Ljunggren Sandén Björn A. Nordelöf Anders André Hampus Tillman Anne-Marie 《The International Journal of Life Cycle Assessment》2020,25(9):1805-1817
The International Journal of Life Cycle Assessment - How to assess impacts of mineral resources is much discussed in life cycle assessment (LCA). We see a need for, and a lack of, a mineral... 相似文献
58.
A process combining dark fermentation and photofermentation for production of hydrogen is interesting due to its potential of producing hydrogen at a high yields. In this study, the hydrogen process is compared to a 2nd generation ethanol process with respect to cost and with the aim of increasing our understanding of the pros and cons and giving a clear picture of the present status of the two processes. The hydrogen production cost was found to be about 20 times higher than the ethanol production cost, 421.7 €/GJ compared to 19.5 €/GJ. The main drawbacks of the hydrogen process are its low productivity, low energy efficiency, and the high cost of buffer and base required to control the pH. 相似文献
59.
Natural killer (NK) cells can be swiftly mobilized by danger signals and are among the earliest arrivals at target organs of disease. However, the role of NK cells in mounting inflammatory responses is often complex and sometimes paradoxical. Here, we examine the divergent phenotypic and functional features of NK cells, as deduced largely from experimental mouse models of pathophysiological responses in the liver, mucosal tissues, uterus, pancreas, joints and brain. Moreover, we discuss how organ-specific factors, the local microenvironment and unique cellular interactions may influence the organ-specific properties of NK cells. 相似文献
60.