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The acrylamide-quenching patterns of the intrinsic tryptophan fluorescence of six cold-soluble monoclonal immunoglobulin M (IgM) and two monoclonal IgM proteins possessing cryoglobulin properties (abnormal cold insolubility) have been compared. Static and dynamic components of quenching have been resolved by a modified form of the Stern-Volmer relationship. The unusual observation of static quenching seen with the multitryptophan containing IgM is determined to be a consequence of essentially homogeneous indole fluorescence arising from conserved tryptophan residues within each homologous immunoglobulin domain. Although the static component of the quenching of the two IgM cryoimmunoglobulins examined is similar to that of the non-cryoimmunoglobulin, IgM, some of the cryoglobulin's tryptophan residues appear to be more kinetically exposed to acrylamide than the tryptophans in the non-cryoglobulin IgM. An unusually large negative entropy of activation observed for the quenching process of both cryoimmunoglobulins suggests some abnormality in the dynamic (flexibility) properties of these proteins. 相似文献
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The immunoglobulin superfamily (IgSF) is an extensively diversified multigene family whose members share a common structural
feature, the Ig fold. Members of the Ig/T-cell antigen receptor (TCR) subset of the IgSF mediate antigen-specific recognition
in adaptive immune responses. Antigen-binding receptors belonging to this subset are present in all species of jawed vertebrates.
To explore whether there are additional structurally related but otherwise distinct members of this subset, we have developed
a technique termed the short-primer polymerase chain reaction (PCR) that targets structurally conserved short motifs in the
Ig fold. Large-scale sequencing efforts and recent advances in information biotechnology, including "electronic PCR," provide
additional computational means to implement similarly directed searches within databases. The use of these approaches has
led to the discoveries of Ig/TCR homologues in a variety of phylogenetically diverse organisms, a diversified family of novel
immune-type receptor genes, as well as a novel human IgSF member. The potential of random sequencing efforts and virtual screening
of databases is described in the context of two novel genes in bony fish. The various methodologies that are discussed and
the examples shown provide means for further investigating, and/or elucidating novel, IgSF receptors as well as components
of pathways that are involved in immune responses in both traditional and nontraditional model systems. 相似文献
127.
The capacity of the hepatocarcinogen dimethylaminoazobenzene and two of its analogs to protect erythrocytes against hemolysis is demonstrated. The aminoazo dye compounds exhibit stabilization at relatively low final concentrations, suggestive of an efficient partitioning of the dye molecules into the erythrocyte membrane. Methyl groups at either the 2 or 3′ position of dimethylaminoazobenzene confer even greater stabilization potential to the basic dye structure. The application of the erythrocyte osmotic hemolysis assay in analysis of carcinogen-membrane interactions is discussed. 相似文献
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Determination of molecular asymmetry in the phosphatidylethanolamine surface distribution in mixed phospholipid vesicles 总被引:2,自引:0,他引:2
B J Litman 《Biochemistry》1974,13(14):2844-2848
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