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971.
Incorporation of Counter Ions in Organic Molecules: New Strategy in Developing Dopant‐Free Hole Transport Materials for Efficient Mixed‐Ion Perovskite Solar Cells
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Jinbao Zhang Bo Xu Li Yang Alba Mingorance Changqing Ruan Yong Hua Linqin Wang Nick Vlachopoulos Mónica Lira‐Cantú Gerrit Boschloo Anders Hagfeldt Licheng Sun Erik M. J. Johansson 《Liver Transplantation》2017,7(14)
Hole transport matertial (HTM) as charge selective layer in perovskite solar cells (PSCs) plays an important role in achieving high power conversion efficiency (PCE). It is known that the dopants and additives are necessary in the HTM in order to improve the hole conductivity of the HTM as well as to obtain high efficiency in PSCs, but the additives can potentially induce device instability and poor device reproducibility. In this work a new strategy to design dopant‐free HTMs has been presented by modifying the HTM to include charged moieties which are accompanied with counter ions. The device based on this ionic HTM X44 dos not need any additional doping and the device shows an impressive PCE of 16.2%. Detailed characterization suggests that the incorporated counter ions in X44 can significantly affect the hole conductivity and the homogeneity of the formed HTM thin film. The superior photovoltaic performance for X44 is attributed to both efficient hole transport and effective interfacial hole transfer in the solar cell device. This work provides important insights as regards the future design of new and efficient dopant free HTMs for photovotaics or other optoelectronic applications. 相似文献
972.
Fulong Qiao Donald R Trout V Margaret Quinton John P Cant 《Journal of applied physiology》2005,99(3):788-798
Thirty-three paired indicator/nutrient dilution curves across the mammary glands of four cows were obtained after rapid injection of para-aminohippuric acid (PAH) plus glucose into the external iliac artery. For the measurement of extracellular volume and kinetics of nutrient uptake from indicator dilution curves, several models of solute dispersion and disappearance have been proposed. The Crone-Renkin models of exchange in a single capillary assume negligible washout of solutes from the extracellular space and do not describe entire dilution curves. The Goresky models include a distribution of capillary transit times to generate whole system outflow profiles but require two indicators to parametize extracellular behavior. A compartmental capillary, convolution integration model is proposed that uses one indicator to account for the extracellular behavior of the nutrient after a paired indicator/nutrient injection. With the use of an iterative approach to least squares, unique solutions for nonexchanging vessel transit time t(mu) and its variance sigma were obtained from all 33 PAH curves. The average of heterogeneous vascular transit times was approximated as 2sigma = 8.5 s. The remainder of indicator dispersion was considered to be due to washout from a well-mixed compartment representing extracellular space that had an estimated volume of 5.5 liters or 24% of mammary gland weight. More than 99% of the variation in the time course of venous PAH concentration after rapid injection into the arterial supply of the mammary glands was explained in an unbiased manner by partitioning the organ into a heterogeneous nonexchanging vessel subsystem and a well-mixed compartmental capillary subsystem. 相似文献
973.
974.
Bacterial tyrosyl-tRNA synthetases occur in two large subfamilies, TyrRS and TyrRZ, that possess about 25% amino acid identity. Their amino-terminal region, the active site domain, is more conserved (>36% identity). The carboxy-terminal segment of these enzymes includes the tRNA binding domain and contains only few conserved residues. Replacement of three of these residues in Acidithiobacillus ferrooxidans TyrRZ revealed that S356 and K395 play roles in tRNA binding, while H306, a residue at the junction of the catalytic and tRNA binding domains, stabilizes the Tyr-AMP:TyrRZ complex. The replacement data suggest that conserved amino acids in A. ferrooxidans TyrRZ and Bacillus stearothermophilus TyrRS play equivalent roles in enzyme function. 相似文献
975.
We describe the informed consent procedures in a research clinic in Santiago, Chile, and a qualitative study that evaluated these procedures. The recruitment process involves information, counseling and screening of volunteers, and three or four visits to the clinic. The study explored the decision-making process of women participating in contraceptive trials through 36 interviews. Women understood the research as experimentation or progress. The decision to participate was facilitated by the information provided; time to consider it and to discuss it with partners or relatives; and perceived benefits such as quality of care, non-cost provision of methods and medical care. For some women, participation was an opportunity to express altruism. The main obstacles for participation were perceived side effects or risks. The final risk-benefit balance was strongly influenced by women's needs. Women perceived that the consent form benefited the clinic, proving that participants had made a free decision, and benefited the volunteers by warranting their right to free medical care. The most important problem detected was occasional misunderstanding of the information given on the form. We concluded that a full decision-making process enhances women's ability to exercise their right to choose, and assures research institutions that trials are conducted without coercion and that the participants are committed to the study. Researchers have the responsibility of conducting this process. 相似文献
976.
Platas G Acero J Borkowski JA González V Portal MA Rubio V Sánchez-Ballesteros J Salazar O Peláez F 《Current microbiology》2001,43(1):43-50
A Simple Tandem Repeat sequence of 11 nucleotides has been found in the ITS1 region of the rDNA of members of Order Xylariales.
The number of repetitions detected ranged from one to six, and they could be found in pure tandem or interspersed. The same
core sequences have also been found in DNA from other organisms, although usually not repeated in tandem. These repetitions
could have been generated by slipped strand mispairing. The presence of this sequence increases the normal rate of divergence
in the ITS1 of the Xylariales. The phylogenetic implications of the presence of this sequence in the molecular taxonomy of
Xylariales are also discussed.
Received: 19 October 2000 / Accepted: 21 December 2000 相似文献
977.
Multiple mechanisms of immune evasion can coexist in melanoma tumor cell lines derived from the same patient 总被引:2,自引:0,他引:2
Real LM Jimenez P Kirkin A Serrano A García A Cantón J Zeuthen J Garrido F Ruiz-Cabello F 《Cancer immunology, immunotherapy : CII》2001,49(11):621-628
Progressive tumor growth may be associated with suppression of the immune response. Many different mechanisms may contribute
to immune evasion. We investigated some of these mechanisms in melanoma cells lines generated from two patients. These cell
lines show a complex pattern of altered HLA expression; however, the resulting phenotype did not satisfactorily explain the
simultaneous evasion of T and NK cell cytotoxicity. Two additional alterations have now been detected in these melanoma cell
lines: (1) resistance to FAS-induced apoptosis caused by defective FAS gene expression, and (2) constitutive expression of
immunosuppressive cytokines. Our results show that several of the major mechanisms for immune evasion may coexist in a single
tumor. This suggests that tumor progression may give rise to an extremely resistant phenotype, which may be an impediment
to some immunotherapeutic strategies. We hypothesize that the simultaneous presence of several mechanisms involved in tumor
immune evasion must be the result of progressive selection of characteristics that are advantageous for tumor survival in
a competent host. Our findings do not support the possibility that FASL expression is a common mechanism of evasion of immune
response in melanoma cells.
Received: 27 January 2000 / Accepted: 28 August 2000 相似文献
978.
Src family kinases are required for integrin-mediated but not for G protein-coupled receptor stimulation of focal adhesion kinase autophosphorylation at Tyr-397 总被引:10,自引:0,他引:10
Plating suspended Swiss 3T3 cells onto fibronectin-coated dishes promoted phosphorylation of endogenous focal adhesion kinase (FAK) at Tyr-397, the major autophosphorylation site, and at Tyr-577, located in the activation loop, as revealed by site-specific antibodies that recognize the phosphorylated form of these residues. Treatment with the selective Src family kinase inhibitor pyrazolopyrimidine 2 (PP-2) markedly reduced the phosphorylation of both Tyr-397 and Tyr-577 induced by fibronectin. Furthermore, fibronectin-mediated FAK phosphorylation at Tyr-397 was dramatically reduced in SYF cells (deficient in Src, Yes, and Fyn expression). Stimulation of Swiss 3T3 cells with bombesin also induced a rapid increase in the phosphorylation of endogenous FAK at Tyr-397. In contrast to the results obtained with fibronectin, PP-2 did not prevent FAK Tyr-397 phosphorylation stimulated by bombesin at a concentration (10 micrometer) that suppressed bombesin-induced FAK Tyr-577 phosphorylation. Similarly, PP-2 did not prevent Tyr-397 phosphorylation in Swiss 3T3 cells stimulated with other G protein-coupled receptor agonists including vasopressin, bradykinin, endothelin, and lysophosphatidic acid. Lysophosphatidic acid also induced FAK phosphorylation at Tyr-397 in SYF cells. Our results identify, for first time, the existence of Src-dependent and Src-independent pathways leading to FAK autophosphorylation at Tyr-397 stimulated by adhesion-dependent signals and G protein-coupled receptor agonists in the same cell. 相似文献
979.
980.