全文获取类型
收费全文 | 4764篇 |
免费 | 483篇 |
国内免费 | 472篇 |
专业分类
5719篇 |
出版年
2024年 | 12篇 |
2023年 | 58篇 |
2022年 | 130篇 |
2021年 | 205篇 |
2020年 | 162篇 |
2019年 | 239篇 |
2018年 | 198篇 |
2017年 | 176篇 |
2016年 | 200篇 |
2015年 | 294篇 |
2014年 | 313篇 |
2013年 | 344篇 |
2012年 | 379篇 |
2011年 | 350篇 |
2010年 | 245篇 |
2009年 | 213篇 |
2008年 | 241篇 |
2007年 | 217篇 |
2006年 | 186篇 |
2005年 | 171篇 |
2004年 | 185篇 |
2003年 | 203篇 |
2002年 | 231篇 |
2001年 | 138篇 |
2000年 | 116篇 |
1999年 | 93篇 |
1998年 | 83篇 |
1997年 | 58篇 |
1996年 | 36篇 |
1995年 | 33篇 |
1994年 | 25篇 |
1993年 | 16篇 |
1992年 | 15篇 |
1991年 | 26篇 |
1990年 | 20篇 |
1989年 | 23篇 |
1988年 | 9篇 |
1987年 | 11篇 |
1986年 | 12篇 |
1985年 | 8篇 |
1984年 | 9篇 |
1983年 | 5篇 |
1982年 | 5篇 |
1981年 | 3篇 |
1979年 | 5篇 |
1973年 | 4篇 |
1966年 | 2篇 |
1959年 | 1篇 |
1948年 | 1篇 |
1947年 | 1篇 |
排序方式: 共有5719条查询结果,搜索用时 0 毫秒
41.
42.
43.
44.
45.
46.
There has been substantial interest of late in using population genetic methods to study sexual conflict, where an allele increases the fitness of one sex at some cost to the other (Mank, 2017). Population genomic scans for sexual conflict offer an important advance given the difficulties of identifying antagonistic alleles from more traditional methods, and could greatly increase our understanding of the extent and loci of sexual conflict. This is particularly true for studies in natural populations, for which obtaining accurate fitness measurements for each sex can be challenging. In this issue of Molecular Ecology, Bissegger, Laurentino, Roesti, and Berner (2019) present a cautionary tale about how to interpret these population genomic data. 相似文献
47.
Kanno Yosuke Shu En Niwa Hirofumi Seishima Mariko Ozaki Kei-ichi 《Molecular biology reports》2021,48(4):3431-3437
Molecular Biology Reports - Systemic sclerosis (SSc) is characterized by peripheral circulatory disturbance and fibrosis in skin and visceral organs. We recently demonstrated that... 相似文献
48.
49.
Chung-Wei Chiang Wen-Chi Shu Jun Wan Beth A. Weaver Meyer B. Jackson 《The Journal of general physiology》2021,153(5)
Spontaneous exocytosis of single synaptic vesicles generates miniature synaptic currents, which provide a window into the dynamic control of synaptic transmission. To resolve the impact of different factors on the dynamics and variability of synaptic transmission, we recorded miniature excitatory postsynaptic currents (mEPSCs) from cocultures of mouse hippocampal neurons with HEK cells expressing the postsynaptic proteins GluA2, neuroligin 1, PSD-95, and stargazin. Synapses between neurons and these heterologous cells have a molecularly defined postsynaptic apparatus, while the compact morphology of HEK cells eliminates the distorting effect of dendritic filtering. HEK cells in coculture produced mEPSCs with a higher frequency, larger amplitude, and more rapid rise and decay than neurons from the same culture. However, mEPSC area indicated that nerve terminals in synapses with both neurons and HEK cells release similar populations of vesicles. Modulation by the glutamate receptor ligand aniracetam revealed receptor contributions to mEPSC shape. Dendritic cable effects account for the slower mEPSC rise in neurons, whereas the slower decay also depends on other factors. Lastly, expression of synaptobrevin transmembrane domain mutants in neurons slowed the rise of HEK cell mEPSCs, thus revealing the impact of synaptic fusion pores. In summary, we show that cocultures of neurons with heterologous cells provide a geometrically simplified and molecularly defined system to investigate the time course of synaptic transmission and to resolve the contribution of vesicles, fusion pores, dendrites, and receptors to this process. 相似文献
50.
Dong Haoru Shu Xinhua Xu Qiang Zhu Chen Kaufmann Andreas M. Zheng Zhi-Ming Albers Andreas E. Qian Xu 《中国病毒学》2021,36(6):1284-1302
Virologica Sinica - Human papillomavirus (HPV) infection identified as a definitive human carcinogen is increasingly being recognized for its role in carcinogenesis of human cancers. Up to... 相似文献