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101.
Electronic and Defective Engineering of Electrospun CaMnO3 Nanotubes for Enhanced Oxygen Electrocatalysis in Rechargeable Zinc–Air Batteries 下载免费PDF全文
Shengjie Peng Xiaopeng Han Linlin Li Shulei Chou Dongxiao Ji Huangjiao Huang Yonghua Du Jian Liu Seeram Ramakrishna 《Liver Transplantation》2018,8(22)
Rational design and massive production of bifunctional catalysts with superior oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) activities are essential for developing metal–air batteries and fuel cells. Herein, controllable large‐scale synthesis of sulfur‐doped CaMnO3 nanotubes is demonstrated via an electrospinning technique followed by calcination and sulfurization treatment. The sulfur doping can not only replace oxygen atoms to increase intrinsic electrical conductivity but also introduce abundant oxygen vacancies to provide enough catalytically active sites, which is further demonstrated by density functional theory calculation. The resulting sulfur‐modified CaMnO3 (CMO/S) exhibits better electrocatalytic activity for ORR and OER in alkaline solution with higher stability performance than the pristine CMO. These results highlight the importance of sulfur treatment as a facile yet effective strategy to improve the ORR and OER catalytic activity of the pristine CaMnO3. As a proof‐of‐concept, a rechargeable Zn–air battery using the bifunctional catalyst exhibits a small charge–discharge voltage polarization, and long cycling life. Furthermore, a solid‐state flexible and rechargeable Zn–air battery gives superior discharge–charge performance and remarkable stability. Therefore, the CMO/S nanotubes might be a promising replacement to the Pt‐based electrocatalysts for metal–air batteries and fuel cells. 相似文献
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Lu Li Linlin Jing Junjiang Wang Wenjuan Xu Xianling Gong Yiye Zhao Ye Ma Xueqing Yao Xuegang Sun 《Journal of cell communication and signaling》2018,12(4):689-698
Colorectal cancer is generally believed to progress through an adenoma - carcinoma sequence. Adenomatous polyposis coli (APC) mutations serve as the initiating event in adenoma formation. The ApcMin/+ mouse harbors a mutation in the APC gene, which is similar or identical to the mutation found in individuals with familial adenomatous polyposis and 70% of all sporadic CRC cases. Autophagy is a constitutive process required for proper cellular homeostasis. However, its role in intestinal adenoma formation is still controversial. Atractylenolide I (AT1) is a sesquiterpenoid that possesses various clinically relevant properties such as anti-tumor and anti-inflammatory activities. The role of AT1 on adenoma formation was tested in ApcMin/+ mice and its underlying mechanism in regulating autophagy was documented. D-dopachrome tautomerase (D-DT) was identified as a potential target of AT1 by an proteomics-based approach. The effects of p53 modification on autophgic flux was monitored in p53?/? and p53+/+ HCT116 cells. Small interfering RNA was used to investigate the function of Atg7 and D-DT on autophagy programme induce by AT1. AT1 effectively reduced the formation of adenoma and downregulated the tumorigenic proteins in ApcMin/+ mice. Importantly, AT1 stimulated autophagic flux through downregulating acetylation of p53. Activation of Sirt1 by AT1 was essential for the deacetylation of p53 and downregulation of D-DT. The lowered expression of COX-2 and β-catenin by AT1 were partly recovered by Atg7 knockdown. AT1 activates autophagy machinery to downregulate D-DT and reduce intestinal adenoma formation. This discovery provides evidence in vivo and in vitro that inducing autophagy by natural products maybe a potential therapy to ameliorate colorectal adenoma formation. 相似文献
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Mao Ding Yang Shen Ping Wang Zhaohong Xie Shunliang Xu ZhengYu Zhu Yun Wang Yongtao Lyu Dewei Wang Linlin Xu JianZhong Bi Hui Yang 《Neurochemical research》2018,43(11):2165-2177
Alzheimer’s disease (AD) is the most common neurodegenerative disease characterized by excessive accumulation of the amyloid-β peptide (Aβ) in the brain, which has been considered to mediate the neuroinflammation process. Microglial activation is the main component of neuroimmunoregulation. In recent years, exosomes isolated from human umbilical cord mesenchymal stem cells (hucMSC-exosomes) have been demonstrated to mimic the therapeutic effects of hucMSCs in many inflammation-related diseases. In this study, exosomes from the supernatant of hucMSCs were injected into AD mouse models. We observed that hucMSC-exosomes injection could repair cognitive disfunctions and help to clear Aβ deposition in these mice. Moreover, we found that hucMSC-exosomes injection could modulate the activation of microglia in brains of the mice to alleviated neuroinflammation. The levels of pro-inflammatory cytokines in peripheral blood and brains of mice were increased and the levels of anti-inflammatory cytokines were decreased. We also treated BV2 cells with hucMSC-exosomes in culture medium. HucMSC-exosomes also had inflammatory regulating effects to alternatively activate microglia and modulate the levels of inflammatory cytokines in vitro. 相似文献
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Jing Kong Yuanjie Dong Yiling Song Xiaoying Bai Xianyi Tian Linlin Xu Shuang Liu Zhenli He 《Journal of Plant Growth Regulation》2016,35(1):31-43
A greenhouse hydroponic experiment was performed to evaluate how peanut seedlings (Arachis hypogaea L.) responded to iron (Fe) deficiency stress in the presence of sodium nitroprusside (SNP), a nitric oxide (NO) donor. The results showed that Fe deficiency inhibited peanut plant growth, decreased chlorophyll and active Fe concentrations, and dramatically disturbed ion balance. The addition of 50, 100, 250, and 500 µM SNP, significantly promoted the absorption of Fe in the cell wall, cell organelles, and soluble fractions, increased the concentrations of active Fe and chlorophyll in peanut plants, and alleviated the excess absorption of manganese (Mn) and copper (Cu) induced by Fe deficiency. In addition, SNP also significantly increased the activities of superoxide dismutase, peroxidase, and catalase, which is beneficial to inhibit the accumulation of malondialdehyde and reactive oxygen species. Addition of 250 µM SNP had the most significant alleviating effect against Fe-deficiency stress, and after 15 days of treatment, the plants with the 250 µM SNP treatment achieved comparable NO levels with those grown under optimal nutrition conditions. However, the effects of SNP were reversed by addition of hemoglobin (Hb, a NO scavenger). These results suggest that NO released from SNP decomposition was responsible for the effect of SNP-induced alleviation on Fe deficiency. 相似文献
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Essential role of Src suppressed C kinase substrates in endothelial cell adhesion and spreading 总被引:1,自引:0,他引:1
Cheng C Liu H Ge H Qian J Qin J Sun L Shen A 《Biochemical and biophysical research communications》2007,358(1):342-348
Integrin-mediated substrate adhesion of endothelial cells leads to dynamic rearrangement of the actin cytoskeleton. Protein kinase C (PKC) stimulates reorganization of microfilaments and adhesion, but the mechanism by which this occurs is unknown. Src suppressed C kinase substrate (SSeCKS) is a PKC substrate that may play an important role in regulating actin cytoskeleton. We found that SSeCKS was localized to focal adhesion sites soon after cell adhesion and that SSeCKS translocated from the membrane to the cytosol during the process of cell spreading. Using small interfering RNAs specific to SSeCKS, we show that RPMVEC cells in which SSeCKS expression was inhibited reduce adhesion and spread on LN through blocking the formation of actin stress fibers and focal adhesions. These results demonstrated SSeCKS modulate endothelial cells adhesion and spreading by reorganization of the actin cytoskeleton. 相似文献
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本文采用几何形态测量法对中国大蹄蝠9个不同地理种群头骨形态变化进行研究。结果表明,不同地理种群的头骨大小及形状存在显著差异,其中云南思茅种群与海南陵水种群差异最大。回归分析表明头骨形态的地理变化与气候因素相关。随着年均温度、年均湿度的升高以及年均降水量的增多,大蹄蝠头骨变小,上颌、齿、咬肌附着部分以及耳蜗部分的形状发生变化。此外,头骨大小与海拔高度呈正相关,头骨形状变化与纬度显著相关。本研究表明对栖息地生态条件的适应是中国大蹄蝠头骨形态地理变化的重要原因。 相似文献
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Linlin Jiang Yingbo Wang Shuhui Zhang Rui He Wei Li Jiao Han Xianguo Cheng 《Plant Growth Regulation》2017,81(1):131-145