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941.
While glycoproteins are abundant in nature, and changes in glycosylation occur in cancer and other diseases, glycoprotein characterization remains a challenge due to the structural complexity of the biopolymers. This paper presents a general strategy, termed GlyDB, for glycan structure annotation of N-linked glycopeptides from tandem mass spectra in the LC-MS analysis of proteolytic digests of glycoproteins. The GlyDB approach takes advantage of low-energy collision-induced dissociation of N-linked glycopeptides that preferentially cleaves the glycosidic bonds while the peptide backbone remains intact. A theoretical glycan structure database derived from biosynthetic rules for N-linked glycans was constructed employing a novel representation of branched glycan structures consisting of multiple linear sequences. The commonly used peptide identification program, Sequest, could then be utilized to assign experimental tandem mass spectra to individual glycoforms. Analysis of synthetic glycopeptides and well-characterized glycoproteins demonstrate that the GlyDB approach can be a useful tool for annotation of glycan structures and for selection of a limited number of potential glycan structure candidates for targeted validation.  相似文献   
942.
BACKGROUND: Shanxi Province has historically reported a high prevalence of NTDs. In order to establish baseline rates for NTDs and discuss the risk factors associated with sociodemographic, maternal characteristics, and geographic factors, we performed the present study using an approach combining population and hospital-based methodologies. METHODS: We used chi(2) and Fisher's exact tests to evaluate variation in the prevalence by selected covariates and computed crude ORs and 95% CIs. Adjusted odds ratios (AORs) were performed using logistic regression with all the covariates included in the model. RESULTS: The overall NTD prevalence during the 3 year study period was 199.38 per 10,000 births, with a higher NTD prevalence clustered in 46 villages within this geographic area. However, no statistical significance was found between NTD prevalence and the elevation of the villages or their distance from coal plants. AORs revealed women aged 20 and above had a lower risk of NTDs compared to those younger than 20 (AOR range 0.4-0.5). A higher risk of NTDs was observed among female infants (AOR 1.50; 95% CI: 1.04-2.17), women with four or more previous births (AOR 2.80; 95% CI: 1.20-6.52), and a previous history of birth defects (AOR 3.23; 95% CI: 1.46-7.12). CONCLUSIONS: This study has documented a high prevalence of NTDs in Shanxi. Similar variations to other reports were found in the risk of NTDs by maternal demographic characteristics and a clustering of NTDs in certain villages that require further exploration.  相似文献   
943.
944.
Marine Biotechnology - Large yellow croaker (Larimichthys crocea), yellow drum (Nibea albiflora), and Chinese seabass (Lateolabrax maculatus) are important economic marine fishes in China. The...  相似文献   
945.
Huang  Jingyu  Wang  Xia  Wang  Xiaoyan  Chen  Yongjuan  Yang  Zhiwei  Xie  Shuguang  Li  Tingting  Song  Shuang 《Aquatic Ecology》2022,56(3):841-857
Aquatic Ecology - Ammonia oxidation driven by ammonia-oxidizing archaea (AOA) and bacteria (AOB) plays a significant role in the nitrogen cycle, but the mechanism of this important action...  相似文献   
946.
Biological Invasions - What kind of genetic structure helps the rapid range expansion of the invasive species is fundamental to understand spread of invasion. The House crow (Corvus splendens), an...  相似文献   
947.
Xiong  Yaoyao  Song  Xiaohang  Kudusi  Zu  Xiongbing  Chen  Minfeng  He  Wei  Qi  Lin 《Functional & integrative genomics》2022,22(5):937-950
Functional & Integrative Genomics - In bladder cancer patients, metastasis after surgical resection and serious adverse reactions brought by cisplatin-based systemic chemotherapy make it urgent...  相似文献   
948.
Organisms Diversity & Evolution - Orthoptera have some of the largest genomes of all insects. At the same time, the architecture of their genomes remains poorly understood. Comparative...  相似文献   
949.
李勋  张艳  宋思梦  周扬  张健 《植物研究》2022,42(2):309-320
为了调整低山丘陵区低效林林分结构,探明马尾松(Pinus massoniana Lamb.)与乡土阔叶树种凋落叶混合分解过程中的全碳(C)释放规律。本研究以华南广泛分布的马尾松、檫木(Sassafras tzumu(Hemsl.) Hemsl)、香樟(Cinnamomum camphora(Linn) Presl)以及香椿(Toona sinensis(A. Juss.) Roem.)凋落叶为研究对象,将这4个树种凋落叶按照不同树种搭配以及混合比例组合为35个处理后进行野外分解实验,探讨C释放最佳的凋落叶树种组合以及混合比例。研究发现:4个单一树种凋落叶之间,香椿凋落叶的C释放最快,檫木和香樟凋落叶次之,马尾松凋落叶最慢。31个混合凋落叶中,C释放的非加和效应随着分解时间的延长表现出先升增强后减弱的趋势,且相对于其他季节,凋落叶在秋季的非加和效应有所减弱。一针一阔树种组合中,香樟凋落叶占比≥30%的处理:PC73和PC64的协同效应较强;一针两阔和一针三阔组合中,阔叶占比≥30%且含有香椿凋落叶的处理:PST613和712、PCT631和613、PSCT7111和6121的协同效应较强。  相似文献   
950.
根据《国际藻类、菌物和植物命名法规》(深圳法规)规则9.2的精神,对我国25个蕨类植物名称的原白中指定的主模式标本错误做了更正,这些植物名称是粤里白、峨眉里白、云南姬蕨、阔基凤丫蕨、川西蹄盖蕨、无盖蹄盖蕨、贡山蹄盖蕨、哈巴蹄盖蕨、假轴果蹄盖蕨、大盖蹄盖蕨、金佛山蛾眉蕨、城口假冷蕨、墨脱红线蕨、镰羽复叶耳蕨、离脉柳叶蕨、弓羽柳叶蕨、木坪贯众、秦岭贯众、强壮鳞毛蕨、西天目鳞毛蕨、百山祖鳞毛蕨、离柄沙皮蕨、毛根蕨、长柄线蕨和长瓦韦。  相似文献   
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