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171.
Palanivel Mathangi Mac Aogáin Micheál Purbojati Rikky W. Uchida Akira Aung Ngu War Lim Serene B. Y. Putra Alexander Drautz-Moses Daniela I. Seaton Shila Rogers Thomas R. Schuster Stephan C. Chotirmall Sanjay H. 《Mycopathologia》2020,185(2):405-408
Mycopathologia - Aspergillus terreus species complex is an opportunistic fungal pathogen increasingly implicated in invasive infection, as well as chronic respiratory disease. Currently, an... 相似文献
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Aluminum and zinc based sacrificial anodes are routinely used to provide corrosion protection to metals (typically steel) exposed to seawater, for example in steel pipelines and storage tanks. However, the high fouling rates experienced in South East Asia means that both the anodes and the metals to be protected rapidly become coated with macrofoulers, which could potentially prevent the anodes from being effective. The present study, involving exposure tests of up to 18 months, indicates that both aluminum and zinc sacrificial anodes remain effective even after being completely coated with biofouling. Furthermore, it was easier to remove the biofouling on the cathodically protected samples than on their unprotected counterparts, possibly due to the higher local pH produced by cathodic protection at the metal and seawater interface. 相似文献
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Elaine T. Lim Soumya Raychaudhuri Stephan J. Sanders Christine Stevens Aniko Sabo Daniel G. MacArthur Benjamin M. Neale Andrew Kirby Douglas M. Ruderfer Menachem Fromer Monkol Lek Li Liu Jason Flannick Stephan Ripke Uma Nagaswamy Donna Muzny Jeffrey G. Reid Alicia Hawes Mark J. Daly 《Neuron》2013,77(2):235-242
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Timothy W. Yu Maria H. Chahrour Michael E. Coulter Sarn Jiralerspong Kazuko Okamura-Ikeda Bulent Ataman Klaus Schmitz-Abe David A. Harmin Mazhar Adli Athar N. Malik Alissa M. D’Gama Elaine T. Lim Stephan J. Sanders Ganesh H. Mochida Jennifer N. Partlow Christine M. Sunu Jillian M. Felie Jacqueline Rodriguez Christopher A. Walsh 《Neuron》2013,77(2):259-273
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Philippe Noriel Q. Pascua Min-Suk Song Hyeok-Il Kwon Gyo-Jin Lim Eun-Ha Kim Su-Jin Park Ok-Jun Lee Chul-Joong Kim Richard J. Webby Robert G. Webster Young-Ki Choi 《Journal of virology》2013,87(19):10552-10562
We previously reported that influenza A/swine/Korea/1204/2009(H1N2) virus was virulent and transmissible in ferrets in which the respiratory-droplet-transmissible virus (CT-Sw/1204) had acquired simultaneous hemagglutinin (HAD225G) and neuraminidase (NAS315N) mutations. Incorporating these mutations into the nonpathogenic A/swine/Korea/1130/2009(H1N2, Sw/1130) virus consequently altered pathogenicity and growth in animal models but could not establish efficient transmission or noticeable disease. We therefore exploited various reassortants of these two viruses to better understand and identify other viral factors responsible for pathogenicity, transmissibility, or both. We found that possession of the CT-Sw/1204 tripartite viral polymerase enhanced replicative ability and pathogenicity in mice more significantly than did expression of individual polymerase subunit proteins. In ferrets, homologous expression of viral RNA polymerase complex genes in the context of the mutant Sw/1130 carrying the HA225G and NA315N modifications induced optimal replication in the upper nasal and lower respiratory tracts and also promoted efficient aerosol transmission to respiratory droplet contact ferrets. These data show that the synergistic function of the tripartite polymerase gene complex of CT-Sw/1204 is critically important for virulence and transmission independent of the surface glycoproteins. Sequence comparison results reveal putative differences that are likely to be responsible for variation in disease. Our findings may help elucidate previously undefined viral factors that could expand the host range and disease severity induced by triple-reassortant swine viruses, including the A(H1N1)pdm09 virus, and therefore further justify the ongoing development of novel antiviral drugs targeting the viral polymerase complex subunits. 相似文献
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