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141.
H. K. Lichtenthaler 《Planta》1970,93(2):143-151
Summary The chromoplasts of yellow perigon leaves of Tulipa derive from the young chloroplasts present in the bud stage. During chromoplast development and thylakoid breakdown many large plastoglobuli (diameter 80–360 nm) are formed. The function of the petal plastoglobuli as stores for the chromoplast lipids such as plastidquinones and carotenoids is discussed. 相似文献
142.
Martina Malnar Marko Kosicek Stefan Mitterreiter Damir Omerbasic Stefan F. Lichtenthaler Alison Goate Silva Hecimovic 《生物化学与生物物理学报:疾病的分子基础》2010,1802(7-8):682-691
The link between cholesterol and Alzheimer's disease has recently been revealed in Niemann–Pick type C disease. We found that NPC1?/? cells show decreased expression of APP at the cell surface and increased processing of APP through the β-secretase pathway resulting in increased C99, sAPPβ and intracellular Aβ40 levels. This effect is dependent on increased cholesterol levels, since cholesterol depletion reversed cell surface APP expression and lowered Aβ/C99 levels in NPC1?/? cells to the levels observed in wt cells. Finding that overexpression of C99, a direct γ-secretase substrate, does not lead to increased intracellular Aβ levels in NPC1?/? cells vs. CHOwt suggests that the effect on intracellular Aβ upon cholesterol accumulation in NPC1?/? cells is not due to increased APP cleavage by γ-secretase. Our results indicate that cholesterol may modulate APP processing indirectly by modulating APP expression at the cell surface and thus its cleavage by β-secretase. 相似文献
143.
Mengzhe Wang Peer‐Hendrik Kuhn Monika S Brill Paolo Canevazzi Regina Feederle Carla Taveggia Thomas Misgeld Stefan F Lichtenthaler 《The EMBO journal》2018,37(7)
Death receptor 6 (DR6) is an orphan member of the TNF receptor superfamily and controls cell death and differentiation in a cell‐autonomous manner in different cell types. Here, we report an additional non‐cell‐autonomous function for DR6 in the peripheral nervous system (PNS). DR6‐knockout (DR6 KO) mice showed precocious myelination in the PNS. Using an in vitro myelination assay, we demonstrate that neuronal DR6 acts in trans on Schwann cells (SCs) and reduces SC proliferation and myelination independently of its cytoplasmic death domain. Mechanistically, DR6 was found to be cleaved in neurons by “a disintegrin and metalloprotease 10” (ADAM10), releasing the soluble DR6 ectodomain (sDR6). Notably, in the in vitro myelination assay, sDR6 was sufficient to rescue the DR6 KO phenotype. Thus, in addition to the cell‐autonomous receptor function of full‐length DR6, the proteolytically released sDR6 can unexpectedly also act as a paracrine signaling factor in the PNS in a non‐cell‐autonomous manner during SC proliferation and myelination. This new mode of DR6 signaling will be relevant in future attempts to target DR6 in disease settings. 相似文献
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147.
H. K. Lichtenthaler 《Photosynthetica》2018,56(2):1-6
On the occasion of the 50th anniversary of the international journal Photosynthetica in 2017 we briefly report on the establishment of this journal and on Dr. Zdeněk ?esták, the renowned researcher of photosynthesis processes who, in cooperation with the Czechoslovak Academy of Sciences, founded this essential science journal in Prague in 1967. 相似文献
148.
Each of 12 cultures ofFusarium, comprising four species, isolated from moldy soybeans suspected of being involved in illness of wild geese, were grown separately in autoclaved moist rice, in autoclaved moist soybeans, and in surface sterilized-disinfected soybeans, assayed for various mycotoxins, and fed to rats. Four additional cultures that produced known toxins on rice were also grown on soybeans as controls. All isolates, except one ofF moniliforme, grown in rice resulted in weight loss of rats, and that one resulted in weight gain; 12 of the isolates caused death. One isolate ofF poae grown in soybeans caused death when consumed by rats, but none of the other 15 resulted in weight loss or overt injury. Much larger amounts of zearalenone, deoxynivalenol (DON), T-2 toxin, neosolaniol, T-2 tetraol, wortmannin, and moniliformin were produced by the cultures on rice than on soybeans, but more HT-2 toxin was produced by one isolate ofF poae grown on soybeans than when grown on rice. Soybeans appear to be a poor substrate for elaboration of most of the toxins produced by the isolates tested. 相似文献