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941.
942.
Heng-Xing Liang Huan-Qin Dai Hai-An Fu Xiao-Ping Dong Abiodun Humphrey Adebayo Li-Xin Zhang Yong-Xian Cheng 《Phytochemistry letters》2010,3(4):181-184
Two new naphthalene acylglucosides, rumexneposides A (1) and B (2), together with 12 known compounds (3-14), were isolated from the roots of Rumex nepalensis. Their structures were established by chemical and spectroscopic methods. The biological activities of compounds 1-14 as well as an additional 11 compounds previously isolated from R. nepalensis and Rumex hastatus (15–25) were evaluated against Mycobacterium tuberculosis, para-aminobenzoic acid (pAba) pathway, and a panel of human cancer cell lines. The results showed that compound 15 was the most active against M. tuberculosis with an MIC value of 2.85 μM similar to that of isoniazid. Compound 5 could inhibit pAba synthetic pathway with an MIC value of 12.6 μM, comparable to that of positive control abyssomicin C, representing a new example of the rare pAba pathway inhibitors. 相似文献
943.
T. Yan W.X. Yan Y. Dong H.J. Wang Y. Yan G.H. Liang 《International biodeterioration & biodegradation》2009,63(8):1079-1087
Marine fouling on floating installations west of Dongsha Islands, the northern South China Sea, was investigated from August 1987 to October 1990. Two buoy stations were deployed at approximately 110 km and 115 km west of Dongshadao, Dongsha Islands, anchored in water at 325 and 345 m depths, and exposed for 8 and 12 months. The experimental panels were fixed on iron structure frames which were connected to the buoy and its mooring system immersed in water at different depths, and retrieved after 4, 8 and 12 months of exposure. Fouling organisms colonizing the buoys and their mooring systems were sampled after 8 and 12 months of deployment. A total of 86 species was collected and identified at these two stations and the fouling community showed a typical oceanic characteristics. Most of the species were mainly found in the top 50 m depth and a striking vertical zonation of species was also observed with depth. The distance from offshore is a major factor in determining the fouling community composition. In terms of biomass, the fouling community was dominated by pedunculate barnacles, hydroids, and algae, followed by common oysters, pearl oysters and acorn barnacles. Biomass of hard fouling organisms increased over time. Under the influence of hydrological currents propagules of communities around the Dongsha Islands may also affect the development of the fouling communities in the offshore waters. 相似文献
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949.
A method for the separation of folinic acid diastereomers by capillary electrophoresis in chiral separation media was developed. Aiming to achieve a good separation of the anionic analytes, a newly synthesized cationic β-cyclodextrin derivative, mono-6-deoxy-6-piperdine-β-cyclodextrin, was applied as the chiral selector. The effect of background electrolyte pH, the concentration of the cyclodextrin additive, and organic modifier on the separation was investigated. A good separation of folinic acid diastereomers was obtained with 30 mmol/L phosphate buffer at pH 6.50 containing 6.0 mmol/L of mono-6-deoxy-6-piperdine-β-cyclodextrin in 10% acetonitrile. Based on the capillary electrophoresis data, the binding constants of each diastereomer with mono-6-deoxy-6-piperdine-β-cyclodextrin were determined. Moreover, a computational modeling study, using the semi-empirical PM3 method, was used to discuss the possible mechanism of separation of folinic acid with mono-6-deoxy-6-piperdine-β-cyclodextrin. 相似文献
950.
Zhuoyang Fan Cheng Chen Xiaoying Pang Zhou Yu Yang Qi Xinyi Chen Huihui Liang Xiaoling Fang Xianyi Sha 《PloS one》2015,10(4)
Genexol-PM, produced by Samyang Company (Korea) is an excellent preparation of paclitaxel (PTX) for clinical cancer treatment. However, it cannot resolve the issue of multidrug resistance (MDR)—a significant problem in the administration of PTX to cancer patients. To increase the efficacy of Genexol-PM against MDR tumors, a mixed micelle capable of serving as a vehicle for PTX was developed, and two substances were chosen as carrier materials: 1) Polyethylene glycol–polylactic acid (PEG-PLA), the original vehicle of Genexol-PM. 2) Vitamin E-TPGS, an inhibitor of P-glycoprotein (P-gp). P-gp has been proven to be the main cause of MDR. In vitro evaluation indicated that the mixed micelle was an ideal PTX delivery system for the treatment of MDR tumors; the mixed micelle also showed a significantly better drug-loading coefficient than Genexol-PM. 相似文献