全文获取类型
收费全文 | 15762篇 |
免费 | 1381篇 |
国内免费 | 1594篇 |
专业分类
18737篇 |
出版年
2024年 | 37篇 |
2023年 | 221篇 |
2022年 | 574篇 |
2021年 | 866篇 |
2020年 | 653篇 |
2019年 | 744篇 |
2018年 | 711篇 |
2017年 | 523篇 |
2016年 | 671篇 |
2015年 | 995篇 |
2014年 | 1151篇 |
2013年 | 1277篇 |
2012年 | 1530篇 |
2011年 | 1284篇 |
2010年 | 794篇 |
2009年 | 758篇 |
2008年 | 819篇 |
2007年 | 692篇 |
2006年 | 605篇 |
2005年 | 551篇 |
2004年 | 396篇 |
2003年 | 399篇 |
2002年 | 357篇 |
2001年 | 244篇 |
2000年 | 208篇 |
1999年 | 239篇 |
1998年 | 134篇 |
1997年 | 144篇 |
1996年 | 137篇 |
1995年 | 120篇 |
1994年 | 116篇 |
1993年 | 88篇 |
1992年 | 96篇 |
1991年 | 74篇 |
1990年 | 82篇 |
1989年 | 61篇 |
1988年 | 58篇 |
1987年 | 43篇 |
1986年 | 50篇 |
1985年 | 50篇 |
1984年 | 33篇 |
1983年 | 21篇 |
1982年 | 22篇 |
1981年 | 11篇 |
1980年 | 10篇 |
1979年 | 16篇 |
1977年 | 12篇 |
1976年 | 9篇 |
1973年 | 9篇 |
1971年 | 6篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
31.
Lubiao Liang Ran Sui Yongxiang Song Yajin Zhao 《Acta biochimica et biophysica Sinica》2021,(11):1558-1566
Tumor acidic microenvironment is the main feature of many solid tumors.As a part of the tumor microenvironment,it has a profound impact on the occurrence and de... 相似文献
32.
Yuanyong Feng Xuedi Cao Bin Zhao Chunyan Song Baoxing Pang Liang Hu Chunmei Zhang Jinsong wang Junqi He Songlin wang 《中国科学:生命科学英文版》2021,(11):1810-1828
Although cisplatin is one of the chemotherapeutics most frequently used in oral squamous cell carcinoma (OSCC) treatment,it exerts multiple side effects and poo... 相似文献
33.
Acireductone dioxygenase (ARD) from Klebsiella ATCC 8724 is a metalloenzyme that is capable of catalyzing different reactions with the same substrates (acireductone and O2) depending upon the metal bound in the active site. A model for the solution structure of the paramagnetic Ni2+-containing ARD has been refined using residual dipolar couplings (RDCs) measured in two media. Additional dihedral restraints
based on chemical shift (TALOS) were included in the refinement, and backbone structure in the vicinity of the active site
was modeled from a crystallographic structure of the mouse homolog of ARD. The incorporation of residual dipolar couplings
into the structural refinement alters the relative orientations of several structural features significantly, and improves
local secondary structure determination. Comparisons between the solution structures obtained with and without RDCs are made,
and structural similarities and differences between mouse and bacterial enzymes are described. Finally, the biological significance
of these differences is considered. 相似文献
34.
35.
Yang CS Lee JS Rodgers M Min CK Lee JY Kim HJ Lee KH Kim CJ Oh B Zandi E Yue Z Kramnik I Liang C Jung JU 《Cell host & microbe》2012,11(3):264-276
Phagocytosis and autophagy are two important and related arms of the host's first-line defense against microbial invasion. Rubicon is a RUN domain containing cysteine-rich protein that functions as part of a Beclin-1-Vps34-containing autophagy complex. We report that Rubicon is also an essential, positive regulator of the NADPH oxidase complex. Upon microbial infection or Toll-like-receptor 2 (TLR2) activation, Rubicon interacts with the p22phox subunit of the NADPH oxidase complex, facilitating its phagosomal trafficking to induce a burst of reactive oxygen species (ROS) and inflammatory cytokines. Consequently, ectopic expression or depletion of Rubicon profoundly affected ROS, inflammatory cytokine production, and subsequent antimicrobial activity. Rubicon's actions in autophagy and in the NADPH oxidase complex are functionally and genetically separable, indicating that Rubicon functions in two ancient innate immune machineries, autophagy and phagocytosis, depending on the environmental stimulus. Rubicon may thus be pivotal to generating an optimal intracellular immune response against microbial infection. 相似文献
36.
37.
38.
39.
40.