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11.
Camilo Ayra-Pardo Maria E. Ochagavia Ben Raymond Asim Gulzar Lianet Rodriguez-Cabrera Claudia Rodriguez de la Noval Ivis Moran Bertot Ryohei Terauchi Kentaro Yoshida Hideo Matsumura Pilar Tellez Rodriguez Daily Hernandez Hemandez Orlando Borras-Hidalgo Denis J. Wright 《Insect Science》2019,26(3):479-498
12.
Monzote Fidalgo L Montalvo Alvarez AM Geigel LF Pérez Pineiro R Suárez Navarro M Rodríguez Cabrera H 《Memórias do Instituto Oswaldo Cruz》2004,99(3):329-330
Current therapy for leishmaniasis is not satisfactory. We describe the in vitro antiproliferative effects of new thiadiazine derivatives against Leishmania amazonensis. The compounds were found to be active against the amastigote form of the parasite, inhibiting parasite growing, from 10 to 89%, at a concentration of 100 ng/ml. This activity suggests that thiadiazine derivatives could be considered as potential antileishmanial compounds. 相似文献
13.
Ailan Guo Lianet Lopez Alevtina Pavlenco Adenrele Akintobi Yingnan Zhang Bridget Currell Somasekar Seshagiri Tong Hao Xinping Yang Yun A Shen Jingjing Li Aaron T Cheng Dryden Bouamalay Adrien Lugari David E Hill Mark L Grimes David G Drubin Barth D Grant Marc Vidal Charles Boone Sachdev S Sidhu Gary D Bader 《Molecular systems biology》2013,9(1)
Src homology 3 (SH3) domains bind peptides to mediate protein–protein interactions that assemble and regulate dynamic biological processes. We surveyed the repertoire of SH3 binding specificity using peptide phage display in a metazoan, the worm Caenorhabditis elegans, and discovered that it structurally mirrors that of the budding yeast Saccharomyces cerevisiae. We then mapped the worm SH3 interactome using stringent yeast two‐hybrid and compared it with the equivalent map for yeast. We found that the worm SH3 interactome resembles the analogous yeast network because it is significantly enriched for proteins with roles in endocytosis. Nevertheless, orthologous SH3 domain‐mediated interactions are highly rewired. Our results suggest a model of network evolution where general function of the SH3 domain network is conserved over its specific form. 相似文献
14.
Inge Schwedt Kerstin Schöne Maike Eckert Manon Pizzinato Laura Winkler Barbora Knotkova Björn Richts Jann-Louis Hau Julia Steuber Raul Mireles Lianet Noda-Garcia Günter Fritz Carolin Mittelstädt Robert Hertel Fabian M. Commichau 《Environmental microbiology》2023,25(12):3604-3622
Glyphosate (GS) inhibits the 5-enolpyruvyl-shikimate-3-phosphate (EPSP) synthase that is required for aromatic amino acid, folate and quinone biosynthesis in Bacillus subtilis and Escherichia coli. The inhibition of the EPSP synthase by GS depletes the cell of these metabolites, resulting in cell death. Here, we show that like the laboratory B. subtilis strains also environmental and undomesticated isolates adapt to GS by reducing herbicide uptake. Although B. subtilis possesses a GS-insensitive EPSP synthase, the enzyme is strongly inhibited by GS in the native environment. Moreover, the B. subtilis EPSP synthase mutant was only viable in rich medium containing menaquinone, indicating that the bacteria require a catalytically efficient EPSP synthase under nutrient-poor conditions. The dependency of B. subtilis on the EPSP synthase probably limits its evolvability. In contrast, E. coli rapidly acquires GS resistance by target modification. However, the evolution of a GS-resistant EPSP synthase under non-selective growth conditions indicates that GS resistance causes fitness costs. Therefore, in both model organisms, the proper function of the EPSP synthase is critical for the cellular viability. This study also revealed that the uptake systems for folate precursors, phenylalanine and tyrosine need to be identified and characterized in B. subtilis. 相似文献