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191.
Apoptosis or programmed cell death plays a pivotal role in embryonic development and maintenance of homeostasis. It is also involved in the etiology of pathophysiological conditions such as cancer, neurodegenerative, autoimmune, infectious, and heart diseases. Consequently, the study of apoptosis is now at center of both basic and clinical research applications. Therefore, sensitive and simple apoptosis detection techniques are required. Here we describe a monoclonal antibody-defined novel antigen, namely NAPO (negative in apoptosis), which is specifically lost during apoptosis. The anti-NAPO antibody recognizes two nuclear polypeptides of 60 and 70 kD. The antigen is maintained in quiescent and senescent cells, as well as in different phases of the cell cycle, including mitosis. Thus, immunodetection of NAPO antigen provides a specific, sensitive, and easy method for differential identification of apoptotic and nonapoptotic cells. 相似文献
192.
193.
Erhan Teker A. Basak Akadam-Teker Oguz Ozturk Allison Pinar Eronat Kivanc Yalin S. Ebru Golcuk Zehra Bugra 《Biochemical genetics》2018,56(3):225-234
Interferon gamma (IFN-γ) is a multifunctional cytokine that plays an important role in modulating almost all phases of the immune response and may be responsible for the increased valvular fibrosis and calcification in the pathogenesis of rheumatic heart disease (RHD). The aim of this study was to investigate the possible relationship between the IFN-γ +874 T/A polymorphism and the severity of valvular damage in the Turkish population. The IFN-γ genotypes were determined in 152 RHD patients and 151 healthy controls by ARMS-PCR. Differences in genotype distribution between patients with RHD and control were evaluated by the χ2 test. All statistical analyses were performed with SPSS 15.0 Software program. Frequency of the AA genotype was found to be significantly lower and the TT genotype significantly higher in the RHD group compared to controls (p = 0.002 and p = 0.018, respectively). The TT genotype was found to be significantly higher (26.8% vs. 9.1%, p = 0.009) and the AA genotype significantly lower (29.1% vs. 8.2%, p = 0.001) in the severe valvular disease (SVD) group compared to mild valvular disease group. In the SVD group, 79 patients had mitral balloon valvotomy and/or mitral valve replacement and had significantly higher TT genotype compared to patients with medical follow-up (30.4% vs. 19%, p = 0.001). The data demonstrated that TT genotype is associated with both RHD and the severity of RHD. 相似文献
194.
Abdul Rehman Muhammad Farooq Levent Ozturk Muhammad Asif Kadambot H. M. Siddique 《Plant and Soil》2018,422(1-2):283-315
Background
Zinc (Zn) deficiency is one of the most important micronutrient disorders affecting human health. Wheat is the staple food for 35% of the world’s population and is inherently low in Zn, which increases the incidence of Zn deficiency in humans. Major wheat-based cropping systems viz. rice–wheat, cotton–wheat and maize–wheat are prone to Zn deficiency due to the high Zn demand of these crops.Methods
This review highlights the role of Zn in plant biology and its effect on wheat-based cropping systems. Agronomic, breeding and molecular approaches to improve Zn nutrition and biofortification of wheat grain are discussed.Results
Zinc is most often applied to crops through soil and foliar methods. The application of Zn through seed treatments has improved grain yield and grain Zn status in wheat. In cropping systems where legumes are cultivated in rotation with wheat, microorganisms can improve the available Zn pool in soil for the wheat crop. Breeding and molecular approaches have been used to develop wheat genotypes with high grain Zn density.Conclusions
Options for improving grain yield and grain Zn concentration in wheat include screening wheat genotypes for higher root Zn uptake and grain translocation efficiency, the inclusion of these Zn-efficient genotypes in breeding programs, and Zn fertilization through soil, foliar and seed treatments.195.
Enhanced expression of the protein kinase substrate p36 in human hepatocellular carcinoma. 总被引:10,自引:0,他引:10
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M Frohlich P Motté K Galvin H Takahashi J Wands M Ozturk 《Molecular and cellular biology》1990,10(6):3216-3223
196.
Sadettin S. Ozturk Bernhard O. Palsson A. Rees Midgley Craig R. Halberstadt 《Biotechnology Techniques》1989,3(1):55-60
Summary A transtubular mammalian cell perfusion chamber has been developed that allows separate delivery and control of medium and gas flow to the cells. The hydrodynamic and mass transfer characteristics of the reactor are studied experimentally for both gas and liquid components. Feasibility and potential of the transtubular reactor are demonstrated by the growth of a hybridoma cell line. 相似文献
197.
198.
Genome‐wide gene expression dynamics of the fungal pathogen Dothistroma septosporum throughout its infection cycle of the gymnosperm host Pinus radiata
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199.
Utilizing biofuels for sustainable development in the panel of 17 developed and developing countries
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Ilhan Ozturk 《Global Change Biology Bioenergy》2016,8(4):826-836
This study investigates the dynamic linkages between biofuels production and sustainable indicators in the panel of 17 developed and developing countries, over the period of 2000–2012. The study emphasized the role of biofuels production in the sustainable development of the region. For this purpose, the study utilized four main sustainable indicators including carbon dioxide emissions, energy intensity, renewable energy generation, and total population that have a significant impact on the biofuels production. The study used dynamic heterogeneous panel econometric technique – Generalized Method of Moments and found that carbon dioxide emissions increase along with the increase in biofuels production. Therefore, the caution should be applied when burning the biofuels during the production process. In addition, renewable electricity generation also increases the biofuels production in the region. The results of robust least square regression confirmed that all of the sustainable indicators have a significant association with the biofuels production, as total primary energy consumption increases the biofuels production, while total population significantly decreases the biofuels production in the region. The results derived to the conclusion that for sustainable development in the region, the policymakers should have to formulate carbon free policies that coupled with the renewable energy sources for emphasizing the life cycle of bioenergy during the production process. 相似文献
200.
Nuri Ozturk Christopher P. Selby Dongping Zhong Aziz Sancar 《The Journal of biological chemistry》2014,289(8):4634-4642
Cryptochrome (CRY) is the primary circadian photoreceptor in Drosophila. Upon light absorption, dCRY undergoes a conformational change that enables it to bind to Timeless (dTIM), as well as to two different E3 ligases that ubiquitylate dTIM and dCRY, respectively, resulting in their proteolysis and resetting the phase of the circadian rhythm. Purified dCRY contains oxidized flavin (FADox), which is readily photoreduced to the anionic semiquinone through a set of 3 highly conserved Trp residues (Trp triad). The crystal structure of dCRY has revealed a fourth Trp (Trp-536) as a potential electron donor. Previously, we reported that the Trp triad played no role in photoinduced proteolysis of dCRY in Drosophila cells. Here we investigated the role of the Trp triad and Trp-536, and the redox status of the flavin on light-induced proteolysis of both dCRY and dTIM and resetting of the clock. We found that both oxidized (FADox) and reduced (FAD⨪) forms of dCRY undergo light-induced conformational change in vitro that enable dCRY to bind JET and that Trp triad and Trp-536 mutations that block known or presumed intraprotein electron transfer reactions do not affect dCRY phototransduction under bright or dim light in vivo as measured by light-induced proteolysis of dCRY and dTIM in Drosophila S2R+ cells. We conclude that both oxidized and reduced forms of dCRY are capable of photosignaling. 相似文献