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181.
Carapa guianensis Aublet. (Meliaceae) is an abundant, canopy tree species often exported as fine wood products. The populations in the Atlantic coastal plain of Costa Rica have undergone a wide variety of human-induced changes in distribution and abundance, including isolation due to deforestation. Using protein electrophoretic analysis of seeds, we investigated the genetic variability and population differentiation of nine populations and the outcrossing rate in two populations that differed in density by a factor of 50%. Average polymorphism (35%) and heterozygosity (0.12) across populations were relatively low in comparison with other tropical tree species. Only 4.6% of the total genetic variability could be attributed to population differentiation even though populations were separated by as much as 70 km. However, genetic differentiation did increase with distance between pairs of compared populations. There were no apparent differences in genetic variation between logged and unlogged forests. The outcrossing rate for each population was not significantly different from 1.0, but there was evidence of nonrandom mating in the lower density population. High levels of gene flow are probably maintained by seed dispersal as seeds travel well throughout flooded forests and rivers. High population density and synchronous flowering also contribute to high outcrossing rates. These genetic characteristics suggest that Carapa guianensis is a good candidate for natural forest management where it occurs at high density. However, current management practices need to account for the rapid rate of deforestation occurring around managed natural forest sites that will result in the elimination of intervening populations. 相似文献
182.
Lisenn Lalier Vincent Mignard Marie-Pierre Joalland Didier Lano Pierre-Franois Cartron Stphen Manon Franois M. Vallette 《Cell death & disease》2021,12(2)
In this work, we have explored the subcellular localization of Bcl2, a major antiapoptotic protein. In U251 glioma cells, we found that Bcl2 is localized mainly in the ER and is translocated to MAM and mitochondria upon induction of apoptosis; this mitochondrial transfer was not restricted to the demonstrator cell line, even if cell-specific modulations exist. We found that the Bcl2/mitochondria interaction is controlled by TOM20, a protein that belongs to the protein import machinery of the mitochondrial outer membrane. The expression of a small domain of interaction of TOM20 with Bcl2 potentiates its anti-apoptotic properties, which suggests that the Bcl2–TOM20 interaction is proapoptotic. The role of MAM and TOM20 in Bcl2 apoptotic mitochondrial localization and function has been confirmed in a yeast model in which the ER–mitochondria encounter structure (ERMES) complex (required for MAM stability in yeast) has been disrupted. Bcl2–TOM20 interaction is thus an additional player in the control of apoptosis.Subject terms: Cancer, Apoptosis, Mitochondria 相似文献
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The biochemical aspects of the immunodominant structures of blood groups antigens are mainly restricted to the following: ABH and Lewis in secretory fluids or on the red blood cells; P system (P1, P, Pk antigens); MN antigens and related; Tn and Tn antigens; Some hypothesis may be put forward for the I, i antigens. Many other antigens seem to be on the dependence of interactions between proteins and lipids of the red cell membrane; such immunodominant structures are not yet known. Except for the ABH and Lewis groups, the biosynthesis pathways are at present unclear. 相似文献
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