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41.
Recovery after African Olive invasion: can a ‘bottom‐up’ approach to ecological restoration work?
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African Olive (Olea europaea ssp. cuspidata) is a densely crowned evergreen small tree, native to eastern Africa that is highly invasive in areas where it has been introduced, including Hawaii and Australia. Invasion by African Olive threatens Cumberland Plain Woodland, a critically endangered grassy eucalypt woodland from western Sydney, Australia, through the formation of a dense mid‐canopy excluding the regeneration of native species. We established a 3‐year field experiment to determine the effectiveness of direct seeding and fire, as techniques for early stage restoration of a 2 ha historically cleared and degraded Cumberland Plain Woodland site after the removal of African Olive. Direct seeding was able to re‐establish a native perennial grass cover which was resistant to subsequent weed invasion and could be managed as an important first stage in woodland restoration with fire and selective herbicide. Fire was able to stimulate some germination of colonising native species from the soil seed bank after 15 years of African Olive invasion; however, germination and establishment of native shrubs from the applied seed mix was poor. We propose a ‘bottom‐up’ model of ecological restoration in such highly degraded sites that uses a combination of direct seeding and stimulation of the soil seed bank by fire, which could be applicable to other degraded grassy woodland sites and plant communities. 相似文献
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A M Mowat M Steel A J Leishman P Garside 《Journal of immunology (Baltimore, Md. : 1950)》1999,163(9):4728-4736
There is considerable evidence that regulatory cytokines play an important role in mediating the systemic tolerance found after oral administration of protein Ags. Although most existing work has focused on cytokines such as IL-4, IL-10, and TGF-beta, recent evidence from TCR transgenic systems suggests that the induction of oral tolerance is accompanied by priming of Ag-specific IFN-gamma production. IFN-gamma has also been implicated as a mediator of T cell tolerance in other models in vivo and in vitro, including that induced by aerosol administration of protein. We show here that feeding tolerogenic doses of OVA primes for IFN-gamma production in the spleen of mice with a normal T cell repertoire. However, depleting IFN-gamma at the time of feeding OVA had no effect on the induction of tolerance. In addition, tolerance was induced normally in both IFN-gamma receptor knockout (IFN-gammaR-/-) and IL-12 p40 knockout (IL-12-/-) mice. This was the case for all components of the systemic immune response and also with a variety of feeding protocols, including those believed to induce distinct regulatory mechanisms. We conclude that IL-12-dependent IFN-gamma-mediated regulation does not play an essential role in oral tolerance. 相似文献
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N Rimmerman D Ben-Hail Z Porat A Juknat E Kozela M P Daniels P S Connelly E Leishman H B Bradshaw V Shoshan-Barmatz Z Vogel 《Cell death & disease》2013,4(12):e949
Cannabidiol (CBD) is a non-psychoactive plant cannabinoid that inhibits cell proliferation and induces cell death of cancer cells and activated immune cells. It is not an agonist of the classical CB1/CB2 cannabinoid receptors and the mechanism by which it functions is unknown. Here, we studied the effects of CBD on various mitochondrial functions in BV-2 microglial cells. Our findings indicate that CBD treatment leads to a biphasic increase in intracellular calcium levels and to changes in mitochondrial function and morphology leading to cell death. Density gradient fractionation analysis by mass spectrometry and western blotting showed colocalization of CBD with protein markers of mitochondria. Single-channel recordings of the outer-mitochondrial membrane protein, the voltage-dependent anion channel 1 (VDAC1) functioning in cell energy, metabolic homeostasis and apoptosis revealed that CBD markedly decreases channel conductance. Finally, using microscale thermophoresis, we showed a direct interaction between purified fluorescently labeled VDAC1 and CBD. Thus, VDAC1 seems to serve as a novel mitochondrial target for CBD. The inhibition of VDAC1 by CBD may be responsible for the immunosuppressive and anticancer effects of CBD. 相似文献
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Silica is ubiquitous in plants and can constitute up to 10% of plant dry mass, varying with phylogeny and soil silicon availability. Plant silicon is an important alleviator of abiotic (salinity, heavy metal, drought) and biotic (herbivore and fungal pathogen) stress. As well as playing an important role in reducing the impact of abiotic stresses, silicon may be an alternative to carbon‐based and other chemical defences. Knowledge of silicon function is predominantly derived from agricultural species and model systems. We investigated the abundance and role of plant silicon at a community level by comparing leaf silicon concentration with defence chemicals, carbon compound concentrations and invertebrate assemblages in vegetation communities from two different soil types with contrasting levels of plant available silicon. We found that the concentrations of silicon in the leaves did not reflect the silicon availability in the soil at a community level. The leaf silica concentration range in the vegetation communities was comparable to other diverse communities reported in the literature, suggesting that the species rather than the environment determine leaf silica concentration. Across sites, leaf silica concentration was significantly negatively correlated with concentrations of carbon, total phenols and weakly with tannins but not with other measured defence compounds. Leaf silica concentration was also negatively correlated with Coleoptera abundance, but not the abundance of any other invertebrate groups measured. Our results suggest that tradeoffs exist between phenolic‐ and tannin‐based defences and provide evidence that leaf silicification may be a more effective defence against some chewing herbivore groups than others. 相似文献