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761.
762.
We have previously proposed that electrocortical activity (EEG) arises as a manifestation of linear waves generated by resonance among telencephalic neurones, and that this activity is controlled in part by ascending neurones from the brain-steim, which regulate the damping of each resonance. The presentexperiments focus on a specific class of ascending neurones, the mesotelencephalic dopaminergic cells, because these cells are thought to mediate important psychological effects, and are conveniently subject to selective lesion. A critical test of the theory is undertaken, by performing selective unilateral lesion, assessing the changes in the power spectrum of the EEG attributable to lesion, and determining whether the changes in phase of the EEG correspond to that predicted from the changes in power. Results support the theory, although the model order applicable in these experiments is inadequate. The consequences of these findings for automata theory, linear network theory and their application to mammalian brains are briefly discussed. 相似文献
763.
Cyclin dependent kinase regulation 总被引:1,自引:0,他引:1
Cyclin-dependent kinases (CDKs) are key regulators of the cell cycle and their activities are consequently tightly regulated. Recent developments in the field of CDK regulation have included the discovery and characterization of CDK inhibitors. These developments have had an impact on our understanding of how other signalling pathways may be linked to the cell cycle machinery. 相似文献
764.
There have been few quantitative studies of modern Mollusca in Britain, especially from wet-ground areas. This is particularly true of the English chalklands, which is surprising given the focus of sub-fossil molluscan research in that area. Those studies that are available highlight the difficulty of separating molluscan faunas from structurally complex habitats such as fen and carr. Quantitative molluscan data from a variety of wet-ground habitats situated within the chalklands of southern England were analysed using an indirect ordination technique, Principal Components Analysis. This demonstrated that the separation of faunas from structurally complex wet-ground habitats is possible. The numerical separation does not rely on indicator species, but is a function of variation of the predominant species. It is suggested that further studies of this type might aid the interpretation of sub-fossil Mollusca from wet-ground contexts. 相似文献
765.
F J Cassels D L Jarboe R H Reid A Lees C D Deal 《Journal of industrial microbiology & biotechnology》1997,19(1):66-70
Enterotoxigenic Escherichia coli (ETEC) cause diarrhea in infants and in travelers to developing countries. The bacteria utilize colonization factors (CF)
for adherence to intestinal epithelia, then release toxins causing diarrhea. CF are strong immunogens as well as protective
antigens. While 20 ETEC CF have been described in the literature, 11 CF are prominent enough to be considered for vaccine
targeting. Of this group, six of the members fall into the CFA/I family of CF. Geysen pin (peptide) linear epitope analysis
demonstrated that three regions containing linear epitopes exist in CFA/I, and that both B- and T-cell linear epitopes of
CFA/I were concentrated at the N-terminus of the protein. We have determined N-terminal sequence of the CFA/I family members
not previously sequenced. Comparison of the protein sequence of the six members of the family showed a strong homology up
to residue 36. A peptide of 36 amino acids representing a consensus of the six sequences was synthesized and used to immunize
animals. The antibody induced to the peptide was reactive to the peptide as well as cross-reactive to each member of the
CFA/I family in Western blots. In addition, this antibody agglutinated three of the six members of the CFA/I family when
added to whole cells expressing the native CF. We are currently evaluating different carriers and conjugation methods to
maximize production of high titer, agglutinating antibody. It is hoped that this and related research will result in an
effective and inexpensive cross-reactive and cross-protective ETEC vaccine.
Received 04 October 1996/ Accepted in revised form 14 April 1997 相似文献
766.
Farzaneh Harraf Anil K Sharma Martin M Brown Kennedy R Lees Richard I Vass Lalit Kalra 《BMJ (Clinical research ed.)》2002,325(7354):17
ObjectiveTo investigate delays in the presentation to hospital and evaluation of patients with suspected stroke.DesignMulticentre prospective observational study.Setting22 hospitals in the United Kingdom and Dublin.Participants739 patients with suspected stroke presenting to hospital.ResultsThe median age of patients was 75 years, and 400 were women. The median delay between onset of symptoms and arrival at hospital was 6 hours (interquartile range 1 hour 48 minutes to 19 hours 12 minutes). 37% of patients arrived within 3 hours, 50% within 6 hours. The median delay for patients using the emergency service was 2 hours 3 minutes (47 minutes to 7 hours 12 minutes) compared with 7 hours 12 minutes (2 hours 5 minutes to 20 hours 37 minutes) for referrals from general practitioners (P<0.0001). Use of emergency services reduced delays to hospital (odds ratio 0.45, 95% confidence interval 0.23 to 0.61). The median time to evaluation by a senior doctor was 1 hour 9 minutes (interquartile range 33 minutes to 1 hour 50 minutes) but was undertaken in only 477 (65%) patients within 3 hours of arrival. This was not influenced by age, sex, time of presentation, mode of referral, hospital type, or the presence of a stroke unit. Computed tomography was requested within 3 hours of arrival in 166 (22%) patients but undertaken in only 60 (8%).ConclusionDelays in patients arriving at hospital with suspected stroke can be reduced by the increased use of emergency services. Over a third of patients arrive at hospital within three hours of stroke; their management can be improved by expediting medical evaluation and performing computed tomography early.