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排序方式: 共有151条查询结果,搜索用时 93 毫秒
101.
J.N. Martin M. Bygdeman M. Ramadan K. Gréen A. Leader V. Lundström N. Wiqvist 《Prostaglandins & other lipid mediators》1976,11(1):123-132
Thirty patients in the 13th–20th week of gestation underwent therapeutic abortion utilizing vaginally administered 16,16-dimethyl-PGE2 (free acid) suppositories. The first 15 patients obtained individual doses in the range of 400–1200 μg given every three hours (mean total dose 4.2 mg). In the following 15 patients a fixed dose schedule was used (800 μg followed by 1000 μg every three hours; mean total dose 5.3 mg). All but one of the 30 patients aborted. The mean induction-abortion interval for all patients was 16.8±6.9 hours (mean ± S.D.) With the fixed dose regime the success rate was 100% and the induction-abortion interval 16.0±5.9 hours. Because gastro-intestinal side effects were minimal, neither anti-emetic nor anti-diarrheic medication was required. A slight elevation of temperature was noted in five patients. The uterine response to the vaginal administration of this compound was characterized by a gradual increase in uterine tonus followed by sustained stimulation. The results are interpreted to suggest that the vaginal administration of 16,16-dimethyl-PGE2 is a useful alternate method for the induction of second trimester abortion. Moreover, this compound seems to cause fewer gastro-intestinal side effects than other prostaglandins administered by the vaginal route at our department. 相似文献
102.
Phosphorylated and other modified forms of eukaryotic ribosomal protein S3 analysed by two-dimensional gel electrophoresis.
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D P Leader 《The Biochemical journal》1980,189(2):241-245
Proteins were isolated from the 40S ribosomal subunits of baby-hamster kidney fibroblasts and subjected to two-dimensional gel electrophoresis. When the cells were pretreated with cyclic AMP or 2-deoxyglucose a more basic derivative of ribosomal protein S3 or S3a was often observed, apparently similar to that previously reported to occur early in liver generation. This derivative was not a dephosphorylated form of protein S3, which protein does not appear to be phosphorylated in normal cells; nor did it correspond to the proteolytic fragment, S3b. It appears to be an oxidation product of protein S3 or S3a, as it can be eliminated by thorough reduction of the ribosomal protein before electrophoresis. In contrast with previous results with Krebs II ascites cells, starvation of baby-hamster kidney fibroblasts of glucose did not cause extensive phosphorylation of ribosomal protein S3. 相似文献
103.
A. Leader M. Bygdeman S.Z. Cekan E. Diczfalusy R. Guerrero J.N. Martin Jr. N. Wiqvist 《Prostaglandins & other lipid mediators》1975,10(6):889-897
This study was undertaken to determine if post-abortion luteolysis in early pregnancy could be accelerated by the administration of 15(S)15-methyl-PGF2 (15-me-PGF2) or delayed following pretreatment with indomethacin. Thirty-nine women were divided into four groups: 7 women were given 400g 15-me-PGF2 extra-amniotically one hour prior to vacuum aspiration; 14 were pretreated with oral indomethacin (50 mg X4) over 24 hours; 7 were given indomethacin (50mg X 6) over 36 hours and 11 served as controls. Plasma progesterone and estradiol were measured at fixed intervals before and after abortion. There was a rapid drop in the plasma progesterone within the first hour after abortion followed by an exponential decline over the next 23 hours. The plasma estradiol fell rapidly during the same period. Under the experimental conditions of this study, neither 15-me-PGF2 nor indomethacin exerted a significant effect on the decline in luteal function. These results are interpreted as suggesting that factors other than prostaglandins have a more significant role in post-abortion luteolysis. 相似文献
104.
A. Leader M. Bygdeman K. Gren J.N. Martin Jr. N. Wiqvist 《Prostaglandins & other lipid mediators》1975,10(2):357-364
Twenty-one women in the 10th–12th week of pregnancy were treated prior to vacuum aspiration with vaginal suppositories containing 16, 16-dimethyl-PGE2 (free acid). An average total dose of 3.4 mg led to abortion or adequate cervical dilatation in all patients. Based upon previous experience with the compound, no prophylactic anti-emetic or anti-diarrhetic medication was given. Gastrointestinal side effects were minimal. Excessive bleeding was not observed. In two cases, slight temperature elevation was noted prior to abortion. The low incidence of side effects in combination with the effectiveness of the compound help to make this method an attractive therapeutic adjunct to vacuum aspiration beyond the 10th week of gestation. Under the experimental conditions of this study, the results suggest that vaginally administered 16, 16-dimethyl-PGE2 can be a safe and effective method for cervical dilatation before vacuum aspiration. 相似文献
105.
Jeffrey Staples Evan K. Maxwell Nehal Gosalia Claudia Gonzaga-Jauregui Christopher Snyder Alicia Hawes John Penn Ricardo Ulloa Xiaodong Bai Alexander E. Lopez Cristopher V. Van Hout Colm O’Dushlaine Tanya M. Teslovich Shane E. McCarthy Suganthi Balasubramanian H. Lester Kirchner Joseph B. Leader Michael F. Murray Jeffrey G. Reid 《American journal of human genetics》2018,102(5):874-889
106.
Barocas Adi Hefner Reuven Ucko Michal Shalmon Benny Leader Noam Geffen Eli 《Biodiversity and Conservation》2022,31(4):1345-1357
Biodiversity and Conservation - Global climatic processes have driven an expansion of arid environments, as well as the human populations that depend on these biomes. Human habitation can influence... 相似文献
107.
Dumont J Million K Sunderland K Rassinier P Lim H Leader B Verlhac MH 《Developmental biology》2007,301(1):254-265
Female meiotic divisions in higher organisms are asymmetric and lead to the formation of a large oocyte and small polar bodies. These asymmetric divisions are due to eccentric spindle positioning which, in the mouse, requires actin filaments. Recently Formin-2, a straight actin filaments nucleator, has been proposed to control spindle positioning, chromosome segregation as well as first polar body extrusion in mouse oocytes. We reexamine here the possible role of Formin-2 during mouse meiotic maturation by live videomicroscopy. We show that Formin-2 controls first meiotic spindle migration to the cortex but not chromosome congression or segregation. We also show that the lack of first polar body extrusion in fmn2(-/-) oocytes is not due to a lack of cortical differentiation or central spindle formation but to a defect in the late steps of cytokinesis. Indeed, Survivin, a component of the passenger protein complex, is correctly localized on the central spindle at anaphase in fmn2(-/-) oocytes. We show here that attempts of cytokinesis in these oocytes abort due to phospho-myosin II mislocalization. 相似文献
108.
109.
J. J. Bedford J. L. Harper J. P. Leader R. A. J. Smith 《Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology》1998,168(2):123-131
Methylamines are frequently present in high concentrations in biological samples, but their separation and quantification
are difficult. Data presented show that methylamines commonly occurring in biological material can be uniquely identified
and quantified by proton nuclear magnetic resonance spectroscopy by recording spectra at both neutral and acid pH. Use of
a high sensitivity probe permits this analysis even in the presence of high water concentrations, allowing accurate quantification
with minimum preparative technique. The method was tested on tissues of the dogfish. Trimethylamine oxide was found in amounts
ranging from 42 mmol kg−1 fresh weight in liver, up to 115 mmol kg−1 fresh weight in heart. Betaine was found to range from 10 mmol kg−1 fresh weight in liver to 49 mmol kg−1 fresh weight in brain. Creatine was not found in heart or liver, but was present in body wall muscle and in brain. Further
analysis using high-performance liquid chromatography allowed determination of urea/methylamine ratios, which ranged from
1.9 in liver to 3.7 in body wall muscle.
Accepted: 7 October 1997 相似文献
110.