Aulus-Cornelius Celse (1ers. après J.-C.) : L’andrologie dans l’œuvre médicale d’un grand encyclopédiste

Knowledge in the field of andrology in the Greek-Roman period are preserved in the workDe re medica by Celsus.     

Le fondateur de la syphiligraphie Alfred Fournier (1832—1914) et sa lutte contre la syphilis

By his studies on syphilis, the creation of the first chair of syphilology, definition of syphilology as a distinct medical speciality and his prophylactic and therapeutic measures, Alfred Fournier made a major contribution to the fight against syphilis and is rightly considered to be the founder of syphilology.     

Forced expression of the cell cycle inhibitor p57<Superscript>Kip2</Superscript> in cardiomyocytes attenuates ischemia-reperfusion injury in the mouse heart

Background  

Myocardial hypoxic-ischemic injury is the cause of significant morbidity and mortality worldwide. The cardiomyocyte response to hypoxic-ischemic injury is known to include changes in cell cycle regulators. The cyclin-dependent kinase inhibitor p57 ^Kip2 is involved in cell cycle control, differentiation, stress signaling and apoptosis. In contrast to other cyclin-dependent kinase inhibitors, p57^Kip2 expression diminishes during postnatal life and is reactivated in the adult heart under conditions of cardiac stress. Overexpression of p57 ^Kip2 has been previously shown to prevent apoptotic cell death in vitro by inhibiting stress-activated kinases. Therefore, we hypothesized that p57 ^Kip2 has a protective role in cardiomyocytes under hypoxic conditions. To investigate this hypothesis, we created a transgenic mouse (R26loxpTA-p57 ^k/+) that expresses p57^Kip2 specifically in cardiac tissue under the ventricular cardiomyocyte promoter Mlc2v.