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V. A. Ivanisenko P. S. Demenkov S. S. Pintus T. V. Ivanisenko N. L. Podkolodny L. N. Ivanisenko A. S. Rozanov A. V. Bryanskaya E. S. Kostrjukova S. A. Levizkiy O. V. Selezneva M. M. Chukin A. K. Larin I. G. Kondratov V. N. Lazarev S. E. Peltek V. M. Govorun N. A. Kolchanov 《Doklady. Biochemistry and biophysics》2012,443(1):76-80
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Mark Lazarev Janette Lamb M Michael Barmada Feng Dai Michelle A Anderson Mitchell B Max David C Whitcomb 《Molecular pain》2008,4(1):1-8
Although a variety of industrial chemicals, as well as several chemotherapeutic agents used to treat cancer or HIV, preferentially induce a peripheral sensory neuropathy what remains unclear is why these agents induce a sensory vs. a motor or mixed neuropathy. Previous studies have shown that the endothelial cells that vascularize the dorsal root ganglion (DRG), which houses the primary afferent sensory neurons, are unique in that they have large fenestrations and are permeable to a variety of low and high molecular weight agents. In the present report we used whole-mount preparations, immunohistochemistry, and confocal laser scanning microscopy to show that the cell body-rich area of the L4 mouse DRG has a 7 fold higher density of CD31+ capillaries than cell fiber rich area of the DRG or the distal or proximal aspect of the sciatic nerve. This dense vascularization, coupled with the high permeability of these capillaries, may synergistically contribute, and in part explain, why many potentially neurotoxic agents preferentially accumulate and injure cells within the DRG. Currently, cancer survivors and HIV patients constitute the largest and most rapidly expanding groups that have chemically induced peripheral sensory neuropathy. Understanding the unique aspects of the vascularization of the DRG and closing the endothelial fenestrations of the rich vascular bed of capillaries that vascularize the DRG before intravenous administration of anti-neoplastic or anti-HIV therapies, may offer a mechanism based approach to attenuate these chemically induced peripheral neuropathies in these patients. 相似文献
24.
Levchuk S Kashparov V Lazarev N Colle C Howard B Yoschenko V Yoschenko L 《Radiation and environmental biophysics》2008,47(1):111-119
Cl-36 is an important component of nuclear waste. The concentrations of stable chlorine (Cl) in pig and cow tissues were measured
to provide information which can be used to parameterize models of 36Cl transfer into agricultural animals. The concentration of stable Cl in cows’ milk was 1.0 ± 0.2 g L−1, in cow muscle it was 0.7 ± 0.2 g kg−1 wet mass (wm) and in pig muscle 0.4 ± 0.1 g kg−1 wm. The concentration of stable Cl in cow and pig liver was 0.9 ± 0.3 g kg−1 wm, which was about two-fold higher than that in the kidney and lung. Due to homeostatic control, stable Cl concentrations
in animal tissues are not related to the amount ingested daily in herbage at intake rates in the normal physiological range
of up to 188 g day−1 for cows and up to 40 g day−1 for pigs. Therefore, the commonly used transfer coefficient is not suitable for use in quantifying the transfer of 36Cl to milk and meat. Since the metabolism of stable Cl and 36Cl in an animal’s body is identical, the average equilibrium ratios of 36Cl to stable Cl in the daily ration (36Cl (g kg−1)/Cl (g kg−1)) and animal tissues will be the same. We therefore conclude that the average equilibrium Cl isotopic ratio in the dietary
daily intake should be used to predict the contamination of meat and milk with 36Cl. 相似文献
25.
Usdin K; Chevret P; Catzeflis FM; Verona R; Furano AV 《Molecular biology and evolution》1995,12(1):73-82
The single most difficult problem in phylogenetic analysis is deciding
whether a shared taxonomic character is due to common ancestry or one that
appeared independently due to convergence, parallelism, or reversion to an
ancestral state. Mammalian L1 retrotransposons undergo periodic
amplifications in which multiple copies of the elements are interspersed in
the genome. Because these elements apparently are transmitted only by
inheritance and are retained in the genome, a shared L1 amplification event
can only be an inherited ancestral character. We propose that L1
amplification events can be an excellent tool for analyzing mammalian
evolution and demonstrate here how we addressed several refractory problems
in rodent systematics using L1 DNA as a taxonomic character.
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Sample complexity frequently interferes with the analysis of low-abundance proteins by two-dimensional gel electrophoresis (2DGE). Ideally, high abundance proteins should be removed, allowing low-abundance proteins to be applied at much higher concentrations than is possible with the unfractionated sample. One approach is to partition the sample in a manner that segregates the bulk of extraneous proteins from the protein(s) of interest. Solution phase isoelectric focusing in the multi-compartment electrolyser generates fractions of discrete isoelectric point (pI) intervals allowing isolated narrow segments of a proteome to be analysed individually by 2DGE. It is particularly useful for the isolation of low-abundance proteins of extremely basic or acidic pI. 相似文献
29.
Some details of the backbone dynamics in the collagen-like triple helix is discussed and the role of backbone dynamics in functioning collagen proteins is illustrated. On a series of oligotripeptides synthetic analogs of collagen formation of high-frequency vibrational backbone dynamics and low-frequency nonlinear backbone dynamics upon stepwise elongation of peptide chain have been described using infrared spectroscopy and hydrogen-exchange method. In the fully completed triple helix the level of high-frequency backbone dynamics is regulated firstly by contact interactions of adjacent atoms and chemical bounded groups, while the level of low-frequency large-amplitude backbone dynamics depends mainly on cooperative interactions attributed by conjugation of interpeptide hydrogen bonds. In native collagens the nonlinear large-amplitude dynamics following by non-denaturational micro-unfolding of the triple-helical structure appears to be under the natural selection control delivering an optimal condition for formation, functioning and utilization of collagen fibrils. 相似文献