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11.
Shemiakin IG Stepanshina VN Korobova OV Anisimova VA Ivanov IIu Lipin MIu Lazarev A Skaldina AI Chernavskaia LA Tarasova TI 《Zhurnal mikrobiologii, epidemiologii, i immunobiologii》2002,(6):30-35
A total of 122 M. tuberculosis clinical drug-resistant strains isolated in Central Russia were studied by spoligotyping and genome fingerprinting techniques. According to spoligotyping results 77% of M. tuberculosis strains were distributed to 13 oligotypes, while 23% of these strains were found to form unique patterns. Most of them belonged to the families Beijing and Haarlem (43.4% and 13.9% respectively). The patterns of the strains of oligotype 12 (7F-7F-7E-0E-78-3E) were identical to those of the strains isolated in Brazil, France and the Netherlands. The strains of the spoligotype 22 (7F-1E-7F-7F-07-3E) had the patterns identical to those of the strains of group S13, also isolated in Brazil. According to genome fingerprinting 31.4% of the strains were found to belong to clusters with the similarity coefficient equal to 1. The strains belonging to genotypes W and A1 were found to prevail in the analyzed group. 相似文献
12.
The protein subunit of RNase P from a thermophilic bacterium, Thermotoga maritima, was overexpressed in and purified from Escherichia coli. The cloned protein was reconstituted with the RNA subunit transcribed in vitro. The temperature optimum of the holoenzyme is near 50°C, with no enzymatic activity at 65°C or above. This finding is in sharp contrast to the optimal growth temperature of T.maritima, which is near 80°C. However, in heterologous reconstitution experiments in vitro with RNase P subunits from other species, we found that the protein subunit from T.maritima was responsible for the comparative thermal stability of such complexes. 相似文献
13.
N. A. Ermolenko U. A. Boyarskikh A. G. Sushko E. N. Voronina I. A. Selezneva T. V. Sinkina A. F. Lazarev V. D. Petrova M. L. Filipenko 《Russian Journal of Genetics》2010,46(12):1486-1491
The frequencies of the polymorphic gene variants MnSOD Ala9Val, GPX1 Pro198Leu, and GSTP1 Ile105Val were estimated in female residents of Altai krai with breast cancer. The frequency distributions of the genotypes for
all genes studied in both patients and control subjects fit the Hardy-Weinberg equilibrium. The estimated frequencies of the
genotypes for the studied genes in the control group did not differ from those earlier reported for Caucasoid women living
in Europe. The T (rs1050450) allele of the GPX1 gene was demonstrated to protect against sporadic breast cancer (OR = 0.74 (95% CI = 0.58−0.94), p = 0.012). Carriers of the genotype combination MnSOD CC + GPX1 CC were found to have a 1.6 times higher risk of sporadic breast cancer compared to the control group (OR = 1.59 (1.05−2.41),
p = 0.0258). The polymorphic loci GSTP1 (rs1695) and MnSOD (rs4880) were not found to be significantly associated with the risk of familial or sporadic breast cancer. 相似文献
14.
Ioshchenko VI Kashparov VA Levchuk SE Bondar' IuO Lazarev NM Ioshchenko MI 《Radiatsionnaia biologiia, radioecologiia / Rossi?skaia akademiia nauk》2010,50(6):632-641
The quantitative "dose rate-effect" dependences are presented for the cytogenetic damages in the seedlings and apical meristem of Scots pine growing in the Chernobyl zone. The specific patterns of dynamics of formation of the morphological effects in the studied species are considered for the conditions of the internal and external chronic irradiation. The correlation dependencies are established for the irradiation effects appearing at the morphological and cell level. The assumption concerning the mechanism of the morphological changes formation is done. 相似文献
15.
Vaĭner AS Boiarskikh UA Voronina EN Selezneva IA Sinkina TV Lazarev AF Petrova VD Filipenko ML 《Molekuliarnaia biologiia》2010,44(5):816-823
Breast cancer is the most incident cancer among women. We investigated the role of polymorphisms of folate metabolizing genes MTHFR (C677T and A1298C), SHMT1 (C1420T) and MTHFD (G1258A) in genetic susceptibility to this type of cancer. We determined allele and genotype frequencies in case (850 women with sporadic form of breast cancer) and control (810 women) groups. None of these polymorphisms was significantly associated with breast cancer risk. To increase statistical power of our study, we conducted a meta-analysis which included published genotype data and the results of our work. Meta-analysis also revealed no significant association of studied SNPs with breast cancer. 相似文献
16.
Gudkov IN Lazarev NM Vechtomov IuV 《Radiatsionnaia biologiia, radioecologiia / Rossi?skaia akademiia nauk》2011,51(6):731-736
Addition to rat ration of ferrocin containing wastes of wine-making formed during the process of wine demetalization in the amount of 0.2 g per animal per day reduces the 137Cs content in organs and tissues in 1.5-7 times. Addition of the above-mentioned substance to the ration of milk cows in the amount of 10-16 g per day reduces the radionuclide content in milk 1.5-2 times in two weeks and more than 3 times in four weeks. 相似文献
17.
Gudkov IN Lazarev NM Grusha VV Bidenko VN 《Radiatsionnaia biologiia, radioecologiia / Rossi?skaia akademiia nauk》2011,51(1):33-40
The retrospective review and analysis of works on some physiologically active trace elements influence on the radionuclides transfer from soil to plants and with forage to animals are presented. Also reviewed is their radioresistance in the contaminated territories. It is shown that some elements--zinc, manganese, cobalt--being appled to the soil at seeding or spraying plants with aqueous solutions and also in complex compounds are capable of reducing significantly the 90Sr and 137Cs transit to agricultural plants, and with forage--into the animals bodies. We have also shown that trace elements reduce the effects of radiation injury. The mechanisms of the radioprotective action of trace elements are also discussed in the paper. 相似文献
18.
Nolte E Huber T Rühm W Kato K Lazarev V Schultz L 《Radiation and environmental biophysics》2005,44(2):87-96
For Hiroshima, a large discrepancy between calculated and measured thermal-neutron fluences had been reported in the past, for distances to the epicenter larger than about 1,000 m. To be more specific, measured (36)Cl concentrations in environmental samples from Hiroshima were too large at these distances, and the ratio of measured to calculated values reached about 70, at a distance of 1,800 m. In an attempt to identify other sources that might also produce (36)Cl in Hiroshima samples, the role of cosmic rays and of neutrons from natural terrestrial sources was investigated. Four reaction mechanisms were taken into account: spallation reactions of the nucleonic (hadronic) component of the cosmic rays on potassium (K) and calcium (Ca) in the sample material, particle emission after nuclear capture of negative muons by K and Ca, reactions of fast-muon induced electromagnetic, and hadronic showers with K and Ca, and neutron capture reactions with (35)Cl in the sample where the neutrons originate from the above three reaction mechanisms and from uranium and thorium decay. These mechanisms are physically described and mathematically quantified. It is shown that among those parameters important for the production of (36)Cl in granite, the chemical composition of the sample, the depth in the quarry where the sample had initially been taken, and the erosion rate at the site of the quarry are most important. Based on these physical, chemical, and geological parameters, (36)Cl concentrations were calculated for different types of granite that are typical for the Hiroshima area. In samples that were of these granite types and that had not been exposed to atomic bomb(A-bomb) neutrons, the (36)Cl concentration was also determined experimentally by means of accelerator mass spectrometry, and good agreement was found with the calculated values. The (36)Cl signal due to natural in situ production was also calculated in granite samples that had been exposed to A-bomb neutrons at distances up to 1,500 m from the hypocenter. It is demonstrated that, for granite samples from Hiroshima exposed to A-bomb neutrons beyond distances of about 1,300 m from the hypocenter, the (36)Cl signal is dominated by natural in situ production. 相似文献
19.
20.
Os'kina NA Boiarskikh UA Lazarev AF Petrova VD Ganov DI Tonacheva OG Lifshits GI Filipenko ML 《Molekuliarnaia biologiia》2012,46(2):234-241
Compelling evidence demonstrates chromosome 8q24 as a prostate cancer susceptibility locus. In present work we studied whether the common variants of 8q24 region, rs6983267 and rs1447295, were associated with the sporadic prostate cancer risk in the Russian population. Polymorphisms were genotyped in 393 case and 384 control Russian Caucasian men from Siberia region. The A allele of rs1447295 was significantly associated with the risk of prostate cancer (OR[CI 95%] = 1.74 [1.26-2.4], p = 7.8 x 10(-4)). A common G-A haplotype for rs6983267 - rs1447295 also showed an association with prostate cancer risk in Russian population (OR[CI 95%] = 2.03 [1.1 - 3.75], p = 0.02). We performed a meta-analysis combining our results with previous studies to evaluate the association between studied SNPs and prostate cancer risk. Meta-analysis has strongly supported the association for these SNPs (p < 10(-6)). Accordingly our study confirms the association between chromosome 8q24 and prostate cancer risk. 相似文献