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Suneetha Lavanya M. Satish Posettihalli R. Korula Ravi J. Suneetha Sujai K. Job Charles K. Balasubramanian Aiylam S. 《Neurochemical research》1998,23(6):907-911
Mycobacterium leprae, the causative agent of leprosy, specifically invades and destroys the peripheral nerve, which results in the main clinical manifestation of the disease. Little is known about the bacteria—nerve protein interaction. We show in the present work that M leprae binds to a 25 kDa glycoprotein from human peripheral nerve. This protein is phosphorylatable and it binds to lectins which have alpha-mannose specificity. This M leprae-protein interaction could be of importance in the pathogenesis of leprosy. 相似文献