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排序方式: 共有313条查询结果,搜索用时 15 毫秒
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Amanda M. Lauer Robert J. Dooling Marjorie R. Leek 《Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology》2009,195(2):193-202
Belgian Waterslager canaries (BWC), bred for a distinct low-pitched song, have an inherited high-frequency hearing loss associated
with hair cell abnormalities. Hair cells near the abneural edge of the papilla, which receive primarily efferent innervation
in normal birds, are among the most severely affected. These cells are thought to support nonlinear active processing in the
avian ear, though the mechanisms are poorly understood. Here we present psychophysical evidence that suggests degraded active
processing in BWC compared to normal-hearing non-BWC. Critical ratios, psychophysical masking patterns and phase effects on
masking by harmonic complexes were measured in BWC and non-BWC using operant conditioning procedures. Critical ratios were
much larger in BWC than in non-BWC at high frequencies. Psychophysical tuning curves derived from the masking patterns for
BWC were broadened at high frequencies. BWC also showed severely reduced phase effects on masking by harmonic complexes compared
to non-BWC. As has been hypothesized previously for hearing-impaired humans, these results are consistent with a loss of active
processing mechanisms in BWC. 相似文献
293.
Matthew Wolfgang Peter Lauer Hae-Sun Park Laurent Brossay Jacques Hbert Michael Koomey 《Molecular microbiology》1998,29(1):321-330
Neisseria gonorrhoeae, the Gram-negative aetiological agent of gonorrhoea, is one of many mucosal pathogens of man that expresses competence for natural transformation. Expression of this phenotype by gonococci appears to rely on the expression of type IV pili (Tfp), but the mechanistic basis for this relationship remains unknown. During studies of gonococcal pilus biogenesis, a homologue of the PilT family of proteins, required for Tfp-dependent twitching motility in Pseudomonas aeruginosa and social gliding motility in Myxococcus xanthus, was discovered. Like the findings in these other species, we show here that gonococcal pilT mutants constructed in vitro no longer display twitching motility. In addition, we demonstrate that they have concurrently lost the ability to undergo natural transformation, despite the expression of structurally and morphologically normal Tfp. These results were confirmed by the findings that two classes of spontaneous mutants that failed to express twitching motility and transformability carried mutations in pilT. Piliated pilT mutants and a panel of pilus assembly mutants were found to be deficient in sequence-specific DNA uptake into the cell, the earliest demonstrable step in neisserial competence. The PilT-deficient strains represent the first genetically defined mutants that are defective in DNA uptake but retain Tfp expression. 相似文献
294.
Population declines of amphibian species in many parts of the world are associated with a lethal fungal pathogen, Batrachochytrium dendrobatidis. Using laboratory challenge assays, we describe the inhibition of B. dendrobatidis by members of eight genera of bacteria isolated from the skin of two amphibian species that exhibit parental care behavior
(Plethodon cinereus and Hemidactylium scutatum). We found that members of three genera of bacteria isolated from the skins of the salamander P. cinereus and members of seven genera isolated from the salamander H. scutatum inhibited the growth of B. dendrobatidis. Understanding how B. dendrobatidis interacts with an ecological community of cutaneous flora may be important in explaining and preventing amphibian population
declines. 相似文献
295.
Analysis of intrapulmonary O(2) concentration by MR imaging of inhaled hyperpolarized helium-3. 总被引:1,自引:0,他引:1
B Eberle N Weiler K Markstaller H Kauczor A Deninger M Ebert T Grossmann W Heil L O Lauer T P Roberts W G Schreiber R Surkau W F Dick E W Otten M Thelen 《Journal of applied physiology》1999,87(6):2043-2052
Inhalation of hyperpolarized (3)He allows magnetic resonance imaging (MRI) of ventilated airspaces. (3)He hyperpolarization decays more rapidly when interacting with paramagnetic O(2). We describe a method for in vivo determination of intrapulmonary O(2) concentrations ([O(2)]) based on MRI analysis of the fate of measured amounts of inhaled hyperpolarized (3)He in imaged regions of the lung. Anesthetized pigs underwent controlled normoventilation in a 1.5-T MRI unit. The inspired O(2) fraction was varied to achieve different end-tidal [O(2)] fractions (FET(O(2))). With the use of a specifically designed applicator, (3)He (100 ml, 35-45% polarized) was administered at a predefined time within single tidal volumes. During subsequent inspiratory apnea, serial two-dimensional images of airways and lungs were acquired. At least once in each animal studied, the radio-frequency excitation used for imaging was doubled at constant FET(O(2)). Signal intensity measurements in regions of interest of the animals' lungs (volume range, 54-294 cm(3)), taken at two different radio-frequency excitations, permitted calculation of [O(2)] in these regions of interest. The [O(2)] fractions in the regions of interest correlated closely with FET(O(2)) (R = 0.879; P < 0.0001). O(2)-sensitive (3)He-MRI may allow noninvasive study of regional distribution of ventilation and alveolar PO(2) in the lung. 相似文献
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Detecting ecological change is a critical first step in the process of local-level adaptation, yet few studies have explored the factors that predict knowledge acquisition following catastrophic events. This article empirically assesses individual variation in the ability of Solomon Islanders to detect ecological change following the alteration of local, shallow-water, marine environments by a major tsunami. We compare the results of marine science surveys with local ecological knowledge of the benthos. We also examine multiple socioeconomic variables, and employ social network analysis to measure the influence of social and expert networks. Results show that villagers with salaried work who are at the intersection of local and global knowledge were the most adept at detecting tsunami-induced changes to benthic surfaces. Social networks had no statistically significant influence on villagers’ abilities to detect change. We argue that these results counter common conceptualizations of indigenous knowledge that emphasize its normative, shared, inter-generationally transmitted characteristics rather than its heterogeneity, emergence, and practical application. Our findings have implications for theory about the foundations of indigenous knowledge research and the design of disaster mitigation efforts or resource management programs that incorporate indigenous ecological knowledge. 相似文献
300.
Mark Pyron Thomas E. Lauer David LeBlanc David Weitzel James R. Gammon 《Hydrobiologia》2008,600(1):205-214
Few studies have addressed within-year temporal variation of IBI scores. We compared index of biotic integrity (IBI) scores
for two summer sampling events from a large river during 25 annual periods. The results indicated that IBI scores calculated
from June samples were not significantly different from July samples. Spatial autocorrelation was present, such that sites
that were closer together produced similar IBI scores and could not be considered independent. Temporal autocorrelation was
present, but was not strong. Lower quality sites (low IBI score) did not have higher variation than higher quality sites.
Our results show that a single sample of fishes by boat electrofisher during the summer in a large river such as the Wabash
River can produce a repeatable estimate of IBI score. Thus, repeated or additional sampling within the summer season to improve
the quality of the evaluation is not warranted.
Handling editor: J. Trexler 相似文献