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排序方式: 共有209条查询结果,搜索用时 15 毫秒
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Latour Martin G.; Desy Francois; Warren Claude; Lavoie Jean-Marc 《Journal of applied physiology》1998,84(5):1653-1660
The present study was conducted to investigatethe in vivo effects of an intrahepatic infusion of deionized waterduring exercise in rats. Adrenodemedullated male Sprague-Dawley ratswere continuously infused for 30 min either at rest or during treadmillexercise (26 m/min, 0% grade). Rats were randomly assigned to one ofthree infusion conditions (52 µl/min) with either deionized water(PW) or saline (PS; NaCl; 0.9%) via the hepatic portal vein ordeionized water through the jugular vein (JW). The exercise periodcaused a significant (P < 0.05)decrease in liver glycogen and relative liver water content andperipheral and portal blood glucose and insulin while increasingperipheral and portal glucagon andK+ plasma concentrations. Theseresponses, with the exception of K+, were not influenced by thedifferent types of infusions. The increase inK+ during exercise wassignificantly (P < 0.05) higher inJW rats than in the PW and PS groups. Both the infusion and exerciseprotocols did not significantly alter the liver weight-to-body weightratio, plasma osmolality, free fatty acids, -hydroxybutyrate,Na+,Cl, vasopressin, andcatecholamine concentrations. It is concluded that an hepatic portalinfusion of deionized water does not specifically alter the metabolicand hormonal responses to exercise in rats. 相似文献
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Cardinal R Rousseau G Bouchard C Vermeulen M Latour JG Pagé PL 《American journal of physiology. Heart and circulatory physiology》2004,286(4):H1496-H1506
Our objective was to create an animal preparation displaying long-term electrical alterations after chronic regional energetic stress without myocardial scarring. An Ameroid (AM) constrictor was implanted around the left circumflex coronary artery (LCx) 2 wk before chronic rapid ventricular pacing (CRP) was initiated at 240 beats/min for 4 wk (CRP-AM). Comparisons were made with healthy canines and canines with either AM or CRP. Unipolar electrograms were recorded from 191 sites in the LCx territory in open-chest, anesthetized animals during sinus rhythm and while pacing at 120-150 beats/min, with bouts of transient rapid pacing (TRP; 240/min). In CRP-AM and AM, ST segment elevation was identified at central sites and ST depression at peripheral sites, both increasing with TRP. In CRP-AM and CRP, the maximum negative slope of unipolar activation complexes was significantly depressed and activation-recovery intervals prolonged. Areas of inexcitability as well as irregular isocontour patterns displaying localized activation-recovery intervals shortening and gradients >20 ms between neighboring sites were identified in one-third of CRP-AM at slow rate, with increasing incidence and magnitude in response to TRP. In CRP-AM, programmed stimulation-induced marked conduction delay and block as well as polymorphic ventricular tachycardias, which stabilized into monomorphic tachycardias with the use of lidocaine or procainamide. Whole cell Na(+) current and channel protein expression were reduced in CRP-AM and CRP. Despite complete constrictor closure, small areas of necrosis were detected in a minority of CRP-AM. Long-term electrical alterations and their exacerbation by TRP contribute to arrhythmia formation in collateral-dependent myocardium subjected to chronic tachycardic stress. 相似文献
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M Da?ron C Bonnerot S Latour W H Fridman 《Journal of immunology (Baltimore, Md. : 1950)》1992,149(4):1365-1373
Murine Fc gamma RII and Fc gamma RIII have highly homologous extracellular domains, but unrelated transmembrane and intracytoplasmic (IC) domains. Murine Fc gamma RIIb1 and b2 are two isoforms of single-chain receptors which differ only by 47 aa in their IC domain. Murine Fc gamma RIII are composed of an IgG-binding alpha-chain, the intracellular portion of which is unrelated to that of Fc gamma RII, and of a homodimeric gamma-chain which also associates with Fc epsilon RI. Murine mast cells express Fc gamma RII, Fc gamma RIII, and Fc epsilon RI. They can be induced to degranulate by murine IgG immune complexes or by F(ab')2 fragments of the rat anti-murine Fc gamma RII/III mAb 2.4G2, complexed to mouse anti-rat (MAR) F(ab')2. In order to determine which murine Fc gamma R can activate mast cells, cDNA encoding murine Fc gamma RIIb1, Fc gamma RIIb2 or Fc gamma RIII alpha were stably transfected into RBL-2H3 cells. Murine Fc gamma RIII but not Fc gamma RIIb1 or Fc gamma RIIb2 induced serotonin release when aggregated by (2.4G2-MAR) F(ab')2 complexes. The respective roles of the IC domains of murine Fc gamma RIII subunits in signal transduction were investigated by stably transfecting cDNA encoding IC-deleted or chimeric murine Fc gamma R into RBL-2H3 cells. The substitution of the IC domain of murine Fc gamma RII for that of murine Fc gamma RIII gamma, but not that of murine Fc gamma RIII alpha, conferred the ability to trigger serotonin release. The deletion of IC sequences of the alpha subunit did not alter the ability of murine Fc gamma RIII to trigger serotonin release. It follows that 1) murine Fc gamma RIII, but not Fc gamma RII, can induce RBL cells to release serotonin, 2) the aggregation of the IC domain of the murine Fc gamma RIII gamma subunit is sufficient, but 3) the IC domain of the murine Fc gamma RIII alpha subunit is neither sufficient nor necessary for triggering serotonin release. 相似文献
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