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21.
Matteo Morello Valentina R Minciacchi Paola de Candia Julie Yang Edwin Posadas Hyung Kim Duncan Griffiths Neil Bhowmick Leland WK Chung Paolo Gandellini Michael R Freeman Francesca Demichelis Dolores Di Vizio 《Cell cycle (Georgetown, Tex.)》2013,12(22):3526-3536
Prostate cancer cells release atypically large extracellular vesicles (EVs), termed large oncosomes, which may play a role in the tumor microenvironment by transporting bioactive molecules across tissue spaces and through the blood stream. In this study, we applied a novel method for selective isolation of large oncosomes applicable to human platelet-poor plasma, where the presence of caveolin-1-positive large oncosomes identified patients with metastatic disease. This procedure was also used to validate results of a miRNA array performed on heterogeneous populations of EVs isolated from tumorigenic RWPE-2 prostate cells and from isogenic non-tumorigenic RWPE-1 cells. The results showed that distinct classes of miRNAs are expressed at higher levels in EVs derived from the tumorigenic cells in comparison to their non-tumorigenic counterpart. Large oncosomes enhanced migration of cancer-associated fibroblasts (CAFs), an effect that was increased by miR-1227, a miRNA abundant in large oncosomes produced by RWPE-2 cells. Our findings suggest that large oncosomes in the circulation report metastatic disease in patients with prostate cancer, and that this class of EV harbors functional molecules that may play a role in conditioning the tumor microenvironment. 相似文献
22.
W.K. Lagrand R. Nijmeijer H.W.M. Niessen C.A. Visser W.Th. Hermens C.E. Hack 《Netherlands heart journal》2002,10(4):189-197
This study was financially supported by the Netherlands Heart Foundation, grant numbers 93-119 and 97-088. Dr. Niessen is a recipient of the Dr. E. Dekker programme of the Netherlands Heart Foundation (D99025). 相似文献
23.
On extended partially linear single-index models 总被引:2,自引:0,他引:2
24.
Ping Kong Brett M Tyler Patricia A Richardson Bobby WK Lee Zhaohui S Zhou Chuanxue Hong 《BMC microbiology》2010,10(1):313