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31.
32.
You‐Min Ying Cui‐Yu Li Yan Chen Jia‐Gui Xiang Ling Fang Jian‐Biao Yao Fa‐Song Wang Ru‐Wei Wang Wei‐Guang Shan Zha‐Jun Zhan 《化学与生物多样性》2015,12(8):1222-1228
Two new triterpenoids, 30‐hydroxylup‐20(29)‐ene 3β‐caffeate ( 1 ) and 24‐nor‐friedelan‐6α,10‐dihydroxy‐1,2‐dioxo‐4,7‐dien‐29‐oic acid ( 2 ), together with eight known compounds 3 – 10 , were isolated from the roots of Celastrus stylosus. The structures of these compounds were elucidated on the basis of spectroscopic analyses. To the best of our knowledge, this represents the first study on the chemical constituents of C. stylosus. The antiproliferative activities of the triterpenoids against six human cancer cell lines (PANC‐1, A549, PC‐3, HepG2, SGC‐7901, and HCCLM3) were evaluated. Compounds 3, 4 , and 10 exhibited comparable activities against PC‐3 and HCCLM3 cell lines as the positive control taxol. 相似文献
33.
Cardiac atlases play an important role in the computer-aided diagnosis of cardiovascular diseases, in particular they need to deal with large and highly variable image datasets. In this paper, we propose a new nonrigid registration algorithm incorporating shape information, to produce comprehensive atlases. For one thing, the multiscale gradient orientation features of images are combined to form the construction of multifeature mutual information. Additionally, the shape information of multiple-objects in images is incorporated into the cost function for registration. We demonstrate the merits of the new registration algorithm on the 3D data sets of 15 patients. The experimental results show that the new registration algorithm can outperform the conventional intensity-based registration method. The obtained atlas can represent the cardiac structures more accurately. 相似文献
34.
Chromium(III) is often claimed to have a positive effect on body composition, while the responses in researches with supplementation
of different chemical form of chromium are various and inconsistent. We have studied the effects of 6 weeks of treatment with
three different forms of chromium (300 μg/kg) as chromium chloride, chromium tripicolinate, and chromium nanocomposite (CrNano)
on growth, body composition, serum parameters, and tissue chromium in rats. The supplementataion of CrNano significantly increased
average daily gain, food efficiency, and lean body mass and decreased fat mass and body fat proportion and serum levels of
glucose, urea nitrogen, triglyceride, and insulin. Chromium contents in liver, kidney, and hind leg muscle were increased
significantly with the addition of CrNano in diet. The results indicate that chromium nanocomposite has higher efficacy on
growth and body composition compared to the traditional chromium agents. 相似文献
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Sun L Zhao H Xu Z Liu Q Liang Y Wang L Cai X Zhang L Hu L Wang G Zha X 《Cellular signalling》2007,19(11):2255-2263
DNA methylation, which affects gene expression and chromatin stability, is catalyzed by DNA methyltransferases (DNMTs) of which DNMT1 possesses most abundant activity. PI3K/PKB pathway is an important pathway involved in cell proliferation, viability, and metabolism and often disrupted in cancer. Here we investigated the impact of PKB on DNMT1 and DNA methylation. Positive correlation between PKB-Ser473-phosphorylation and DNMT1 protein level in 17 human cell lines (p<0.01) and in 27 human bladder cancer tissues (p<0.05) was found. With activator, inhibitor, siRNA and constitutively active or dominant-negative plasmids of PKB, we found that PKB increased the protein level of DNMT1 without coordinate mRNA change, which was specific rather than due to cell-cycle change. PKB enhanced DNMT1 protein stability independent of de novo synthesis of any protein, which was attributed to down-regulation of N-terminal-120-amino-acids-dependent DNMT1 degradation via ubiquitin-proteasome pathway. Gsk3beta inhibitor rescued the decrease of DNMT1 by PKB inhibition, suggesting that Gsk3beta mediated the stabilization of DNMT1 by PKB. Then role of PKB regulating DNMT1 was investigated. Inhibition of PKB caused observable DNA hypomethylation and chromatin decondensation and DNMT1 overexpression partially reversed cell growth inhibition by PKB inhibition. In conclusion, our results suggested that PKB enhanced DNMT1 stability and maintained DNA methylation and chromatin structure, which might contribute to cancer cell growth. 相似文献
37.
Peng H. Zhang G. H. Lu H. Q. Kong X. W. Zha X. D. Wang Y. Z. 《Applied Biochemistry and Microbiology》2022,58(5):627-634
Applied Biochemistry and Microbiology - Arthrobotrys oligospora is one of the most commonly studied fungi that can form abundant traps to capture and consume nematodes at the parasitic stage.... 相似文献
38.
Zhang Jianmin Zha Wenzhang Qian Changchun Ding Aixing Mao Zhongqi 《Biochemical genetics》2022,60(2):558-575
Biochemical Genetics - Resistance to cisplatin (CDDP) remains a major challenge for the treatment of gastric cancer (GC). Circular RNAs (circRNAs) have been implicated in the development of CDDP... 相似文献
39.
Deng Kun Li Li Li Linling Xu Feng Yuan Honghui Zha Sanxing Xiao Xian Yu Jie Cheng Shuiyuan Cheng Hua 《Plant Molecular Biology Reporter》2022,40(2):232-246
Plant Molecular Biology Reporter - Flavonoids from Ginkgo biloba have antioxidant and free radical scavenging activity. In the present study, we used different concentrations of OS (organic... 相似文献
40.