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81.
Karimi Farzaneh Amiri-Moghaddam Seyedeh Mina Bagheri Zakieh Bahrami Ahmad Reza Goshayeshi Ladan Allahyari Abolghasem Mirsadraee Marjane Fanipakdel Azar Bari Alireza Emadi-Torghabeh Ali Kerachian Mohammad Amin Rahimi Hossein Matin Maryam M. 《Molecular biology reports》2021,48(3):2273-2284
Molecular Biology Reports - Genome-wide association studies have revealed that some single nucleotide polymorphisms at 8q24, such as rs6983267, might be effective in susceptibility to various... 相似文献
82.
Nafiseh Pakravan Ladan Langroudi Monire Hajimoradi Zuhair Mohammad Hassan 《Cell stress & chaperones》2010,15(6):977-984
Heat-shock proteins have biochemical and immunological roles in chaperoning/signaling and activation of innate and adaptive
immune responses, respectively. Their effect on the immune response is due to a phenomenon known as cross-priming of antigen,
in which exogenous antigens are presented via MHC class I by antigen presenting cells. GP96 exerts adjuvant activity with
some viral and bacterial antigens when applied in the form of a DNA vaccine. In this study, animals with Her2-expressing tumors
were vaccinated by co-administration of GP96+ Her2/neu DNA vaccines. Analyses of the immune response, 2 weeks after the last
immunization revealed decreased CD4+ CD25+ Foxp3+ naturally occurring regulatory T cells (Tregs) at the tumor site and increased
IFN-γ/IL-4 level. Nevertheless, the graph of tumor size demonstrated a bi-phasic pattern in which partial control of tumor
progression initially occurred, but finally its effectiveness was inversely affected by tumor size. 相似文献