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11.
Dr. Lad Čelakovský 《Plant Systematics and Evolution》1883,33(5):137-141
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12.
Dr. Lad Čelakovský 《Plant Systematics and Evolution》1874,24(3):75-82
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13.
Dr. Lad Čelakovský 《Plant Systematics and Evolution》1873,23(6):177-180
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14.
Dr. Lad Čelakovský 《Plant Systematics and Evolution》1872,22(12):381-382
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15.
Dr. Lad Čelakovský 《Plant Systematics and Evolution》1890,40(8):287-297
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16.
Mohan Babu Roland Arnold Cedoljub Bundalovic-Torma Alla Gagarinova Keith S. Wong Ashwani Kumar Geordie Stewart Bahram Samanfar Hiroyuki Aoki Omar Wagih James Vlasblom Sadhna Phanse Krunal Lad Angela Yeou Hsiung Yu Christopher Graham Ke Jin Eric Brown Ashkan Golshani Philip Kim Gabriel Moreno-Hagelsieb Jack Greenblatt Walid A. Houry John Parkinson Andrew Emili 《PLoS genetics》2014,10(2)
Large-scale proteomic analyses in Escherichia coli have documented the composition and physical relationships of multiprotein complexes, but not their functional organization into biological pathways and processes. Conversely, genetic interaction (GI) screens can provide insights into the biological role(s) of individual gene and higher order associations. Combining the information from both approaches should elucidate how complexes and pathways intersect functionally at a systems level. However, such integrative analysis has been hindered due to the lack of relevant GI data. Here we present a systematic, unbiased, and quantitative synthetic genetic array screen in E. coli describing the genetic dependencies and functional cross-talk among over 600,000 digenic mutant combinations. Combining this epistasis information with putative functional modules derived from previous proteomic data and genomic context-based methods revealed unexpected associations, including new components required for the biogenesis of iron-sulphur and ribosome integrity, and the interplay between molecular chaperones and proteases. We find that functionally-linked genes co-conserved among γ-proteobacteria are far more likely to have correlated GI profiles than genes with divergent patterns of evolution. Overall, examining bacterial GIs in the context of protein complexes provides avenues for a deeper mechanistic understanding of core microbial systems. 相似文献
17.
Green EC Gkoutos GV Lad HV Blake A Weekes J Hancock JM 《Bioinformatics (Oxford, England)》2005,21(12):2930-2931
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19.
Joshi K Lad S Kale M Patwardhan B Mahadik SP Patni B Chaudhary A Bhave S Pandit A 《Prostaglandins, leukotrienes, and essential fatty acids》2006,74(1):17-21
Considerable clinical and experimental evidence now supports the idea that deficiencies or imbalances in certain highly unsaturated fatty acids may contribute to a range of common developmental disorders including Attention Deficit Hyperactivity Disorder (ADHD). Few intervention studies with LCPUFA supplementation have reported inconsistent and marginal results. This pilot study evaluates the effect of alpha linolenic acid (ALA)-rich nutritional supplementation in the form of flax oil and antioxidant emulsion on blood fatty acids composition and behavior in children with ADHD. Post-supplementation levels of RBC membrane fatty acids were significantly higher than pretreatment levels as well as the levels in control. There was significant improvement in the symptoms of ADHD reflected by reduction in total hyperactivity scores of ADHD children derived from ADHD rating scale. 相似文献
20.
Kiema T Lad Y Jiang P Oxley CL Baldassarre M Wegener KL Campbell ID Ylänne J Calderwood DA 《Molecular cell》2006,21(3):337-347
The ability of adhesion receptors to transmit biochemical signals and mechanical force across cell membranes depends on interactions with the actin cytoskeleton. Filamins are large, actin-crosslinking proteins that connect multiple transmembrane and signaling proteins to the cytoskeleton. Here, we describe the high-resolution structure of an interface between filamin A and an integrin adhesion receptor. When bound, the integrin beta cytoplasmic tail forms an extended beta strand that interacts with beta strands C and D of the filamin immunoglobulin-like domain (IgFLN) 21. This interface is common to many integrins, and we suggest it is a prototype for other IgFLN domain interactions. Notably, the structurally defined filamin binding site overlaps with that of the integrin-regulator talin, and these proteins compete for binding to integrin tails, allowing integrin-filamin interactions to impact talin-dependent integrin activation. Phosphothreonine-mimicking mutations inhibit filamin, but not talin, binding, indicating that kinases may modulate this competition and provide additional means to control integrin functions. 相似文献