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91.
A. Ortiz de Zrate A. C. Villaro O. Díaz De Rada L. Montuenga J. C. Etayo P. Sesma J. J. Vzquez 《Journal of morphology》1993,216(3):339-350
Pancreatic ducts of young posthatching Rana temporaria tadpoles are the main component of the developing pancreas. At this stage (free-swimming tadpoles with internal gills), duct cells display a high degree of development of basal and lateral outfoldings of the cell membrane with extensive interdigitation, and numerous mitochondria are present throughout the cytoplasm. Wide intercellular spaces also exist, sometimes forming canaliculi-like structures. Since these traits are characteristic of cells engaged in osmotic regulation, we suggest the possibility that this temporary duct system participates in such control. Duct cells in tadpoles with well-developed hindlegs have diminished interdigitation, and mitochondria are localized apically. © 1993 Wiley-Liss, Inc. 相似文献
92.
Bo Chang Richard S Smith Maureen Peters Olga V Savinova Norman L Hawes Adriana Zabaleta Steven Nusinowitz Janice E Martin Muriel L Davisson Constance L Cepko Brigid LM Hogan Simon WM John 《BMC genetics》2001,2(1):1-12
Background
Glaucoma is a common disease but its molecular etiology is poorly understood. It involves retinal ganglion cell death and optic nerve damage that is often associated with elevated intraocular pressure. Identifying genes that modify glaucoma associated phenotypes is likely to provide insights to mechanisms of glaucoma. We previously reported glaucoma in DBA/2J mice caused by recessive alleles at two loci, isa and ipd, that cause iris stromal atrophy and iris pigment dispersion, respectively. A approach for identifying modifier genes is to study the effects of specific mutations in different mouse strains. When the phenotypic effect of a mutation is modified upon its introduction into a new strain, crosses between the parental strains can be used to identify modifier genes. The purpose of this study was to determine if the effects of the DBA/2J derived isa and ipd loci are modified in strain AKXD-28/Ty. 相似文献93.
94.
Presence of Locusta diuretic hormone in endocrine cells of the ampullae of locust Malpighian tubules
L. M. Montuenga E. Zudaire M. A. Prado N. Audsley M. A. Burrell G. M. Coast 《Cell and tissue research》1996,285(2):331-339
This is an investigation of an endocrine cell type in the midgut of the migratory locust Locusta migratoria. This cell type is found in the posterior region of the midgut and is especially common in the ampullae through which Malpighian
tubules drain into the gut at the midgut-hindgut junction. Strong Locusta diuretic hormone-like immunoreactivity in these cells was colocalized with FMRFamide- and substance P-like immunoreactivities.
At the ultrastructural level, immunoreactivity for Locusta diuretic hormone was found in spherical granules (mean diameter of 450 nm), the contents of which showed variable electron
density. Fractionation of a methanolic extract of the ampullae by reversed-phase high performance liquid chromatography revealed
the presence of two peaks of Locusta diuretic hormone-like immunoreactive material, both of which stimulate cyclic AMP production by isolated Malpighian tubules.
The more hydrophobic material is most likely Locusta diuretic hormone, which has the same retention time when chromatographed under identical conditions.
Received: 15 September 1995 / Accepted: 16 February 1996 相似文献