全文获取类型
收费全文 | 111篇 |
免费 | 9篇 |
专业分类
120篇 |
出版年
2021年 | 1篇 |
2019年 | 1篇 |
2018年 | 1篇 |
2016年 | 2篇 |
2015年 | 3篇 |
2014年 | 7篇 |
2013年 | 5篇 |
2012年 | 8篇 |
2011年 | 6篇 |
2010年 | 6篇 |
2009年 | 7篇 |
2008年 | 5篇 |
2007年 | 3篇 |
2006年 | 2篇 |
2005年 | 6篇 |
2004年 | 7篇 |
2003年 | 7篇 |
2002年 | 6篇 |
2001年 | 8篇 |
2000年 | 3篇 |
1999年 | 5篇 |
1998年 | 1篇 |
1997年 | 1篇 |
1996年 | 3篇 |
1994年 | 1篇 |
1993年 | 4篇 |
1992年 | 1篇 |
1990年 | 1篇 |
1989年 | 4篇 |
1988年 | 1篇 |
1987年 | 1篇 |
1982年 | 1篇 |
1980年 | 1篇 |
1975年 | 1篇 |
排序方式: 共有120条查询结果,搜索用时 15 毫秒
111.
112.
113.
J F Ramírez-Davila E Porcayo-Camargo JR Sánchez-Pale LM Vázquez-García 《Neotropical Entomology》2012,41(1):9-16
During the last five?years, Bactericera cockerelli Sulc. has caused significant economic losses in potato production in Mexico, due to the purple top and zebra chip diseases, since it acts as the vector of Candidatus Liberibacter psyllaurous. Despite its importance as a vector of serious potato diseases, the knowledge of its spatial distribution behavior, which could improve the efficiency of control measures, is entirely lacking. The main objective of this work was to compare the spatial distribution of the immature and adult stages of B. cockerelli obtained in a potato field by means of transect and quadrant sampling techniques and of geostatistics tools that allow the visualization of its spatial distribution in the field. Transect and quadrant samplings showed that the immature stages (eggs and nymphs) of B. cockerelli present a clustered distribution. The validation of the achieved semivariograms in the three dates of sampling corroborated the aggregated distribution of immatures and adults of the insect. The maps obtained in the sampling by using the quadrant or the transect approaches reflect the aggregated structure of the insect populations which did not infest 100% of the plot area. This allowed us to identify infested and free areas, what will aid in decisions for selecting alternatives of control. 相似文献
114.
Retinal neovascularization is a critical component in the pathogenesis of common ocular disorders that cause blindness, and treatment options are limited. We evaluated the therapeutic effect of a DNA enzyme targeting c-jun mRNA in mice with pre-existing retinal neovascularization. A single injection of Dz13 in a lipid formulation containing N-[1-(2,3-dioleoyloxy)propyl]-N,N,N-trimethylammonium methyl-sulfate and 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine inhibited c-Jun expression and reduced retinal microvascular density. The DNAzyme inhibited retinal microvascular density as effectively as VEGF-A antibodies. Comparative microarray and gene expression analysis determined that Dz13 suppressed not only c-jun but a range of growth factors and matrix-degrading enzymes. Dz13 in this formulation inhibited microvascular endothelial cell proliferation, migration and tubule formation in vitro. Moreover, animals treated with Dz13 sensed the top of the cage in a modified forepaw reach model, unlike mice given a DNAzyme with scrambled RNA-binding arms that did not affect c-Jun expression. These findings demonstrate reduction of microvascular density and improvement in forepaw reach in mice administered catalytic DNA. 相似文献
115.
Midwinter RG Maghzal GJ Dennis JM Wu BJ Cai H Kapralov AA Belikova NA Tyurina YY Dong LF Khachigian L Neuzil J Kagan VE Stocker R 《Free radical biology & medicine》2012,52(5):871-879
Probucol inhibits the proliferation of vascular smooth muscle cells in vitro and in vivo, and the drug reduces intimal hyperplasia and atherosclerosis in animals via induction of heme oxygenase-1 (HO-1). Because the succinyl ester of probucol, succinobucol, recently failed as an antiatherogenic drug in humans, we investigated its effects on smooth muscle cell proliferation. Succinobucol and probucol induced HO-1 and decreased cell proliferation in rat aortic smooth muscle cells. However, whereas inhibition of HO-1 reversed the antiproliferative effects of probucol, this was not observed with succinobucol. Instead, succinobucol but not probucol induced caspase activity and apoptosis, and it increased mitochondrial oxidation of hydroethidine to ethidium, suggestive of the participation of H(2)O(2) and cytochrome c. Also, succinobucol but not probucol converted cytochrome c into a peroxidase in the presence of H(2)O(2), and succinobucol-induced apoptosis was decreased in cells that lacked cytochrome c or a functional mitochondrial complex II. In addition, succinobucol increased apoptosis of vascular smooth muscle cells in vivo after balloon angioplasty-mediated vascular injury. Our results suggest that succinobucol induces apoptosis via a pathway involving mitochondrial complex II, H(2)O(2), and cytochrome c. These unexpected results are discussed in light of the failure of succinobucol as an antiatherogenic drug in humans. 相似文献
116.
117.
118.
Recently, decreased activity levels have been observed in pigs treated postoperatively with transdermal delivery of fentanyl
(TD-fentanyl) after isoflurane anaesthesia. Whether the change in behaviour is related to opioid-induced sedation or to insufficient
pain relief remains to be investigated. This study was therefore undertaken to evaluate the effect of TD-fentanyl 50 μg h-1 on the activity level with and without isoflurane anaesthesia. Eight pigs (25.4 ± 5.2 kg) were submitted to a cross-over
study and given two treatments; 1) fentanyl patch applied after 30 minutes of anaesthesia (treatment A/F) and 2) fentanyl
patch without anaesthesia (treatment F). The pigs' behaviour was observed from a video recording instantaneously every 10
minutes for 24 h before treatments and up to 72 h after the patch attachment. Venous blood samples were taken 1, 6, 12, 24,
48 and 72 h after the patch application. The behaviour recordings showed that TD-fentanyl did not produce sedation in any
pig. No differences were found between the two treatments in activity level, weight gain or serum fentanyl concentration.
This concentration measured after 24 h was 0.27 ± 0.11 ng ml-1 and 0.47 ± 0.40 ng ml-1 in the A/F and F group, respectively. 相似文献
119.
120.
Bo Chang Richard S Smith Maureen Peters Olga V Savinova Norman L Hawes Adriana Zabaleta Steven Nusinowitz Janice E Martin Muriel L Davisson Constance L Cepko Brigid LM Hogan Simon WM John 《BMC genetics》2001,2(1):1-12