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951.
Agatha A. van der Klaauw Sophie Croizier Edson Mendes de Oliveira Lukas K.J. Stadler Soyoung Park Youxin Kong Matthew C. Banton Panna Tandon Audrey E. Hendricks Julia M. Keogh Susanna E. Riley Sofia Papadia Elana Henning Rebecca Bounds Elena G. Bochukova Vanisha Mistry Stephen O’Rahilly Richard B. Simerly I. Sadaf Farooqi 《Cell》2019,176(4):729-742.e18
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954.
Han Seungsu Lee Yeongmok Park Eun Joo Min Myung Ki Lee Yongsang Kim Tae-Houn Kim Beom-Gi Lee Sangho 《Plant molecular biology》2019,100(3):319-333
Plant Molecular Biology - We determined the structure of OsPYL/RCAR3:OsPP2C50 complex with pyrabactin. Our results suggest that a less-conserved phenylalanine of OsPYL/RCAR subfamily I is... 相似文献
955.
Park Soomin Steen Collin J. Fischer Alexandra L. Fleming Graham R. 《Photosynthesis research》2019,141(3):367-376
Photosynthesis Research - Although the importance of nonphotochemical quenching (NPQ) on photosynthetic biomass production and crop yields is well established, the in vivo operation of the... 相似文献
956.
Lee Jun-Won Oh Ji Eun Rhee Ki-Jong Yoo Byung-Su Eom Young Woo Park Sang Wook Lee Ji Hyun Son Jung-Woo Youn Young Jin Ahn Min-Soo Ahn Sung-Gyun Kim Jang-Young Lee Seung-Hwan Yoon Junghan 《Molecular and cellular biochemistry》2019,453(1-2):197-203
Molecular and Cellular Biochemistry - Electron transfer occurs through heme-Fe across the cytochrome c protein. The current models of long range electron transfer pathways in proteins include... 相似文献
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958.
Eun Hye Park Stephen Keeley Cristina Savin James B. Ranck André A. Fenton 《Neuron》2019,101(2):285-293.e5
959.
The wave wash hunting employed by Orcinus orca, also known as killer whales, is unique in that the prey is hunted outside of the water by generating waves. To quantitatively analyze the specific mechanism of the wave wash, data were obtained using computational fluid dynamics (CFD), and wave theory was introduced as the theoretical background to clarify the mechanism. The relationships between the swimming characteristics and wave parameters are defined in this paper. The results obtained by numerical investigation revealed that the wavelength increased with the swimming speed. Additionally, the wave height increased as the swimming speed increased and the swimming depth became shallower, and subsequently converged to a maximum of 2.42 m. The success of hunting is determined by two wave parameters, which indicate the intensity of the wave wash: the wave height and force exerted on the prey. The metabolic rate and the drag force are considered to evaluate the efficiency of the locomotion, which varied according to the swimming speed (V) and swimming depth (d) of the whales. To generate hunting waves efficiently, the optimal ranges of V and d were estimated to be 3 ~ 5 m/s and 0.5 m ~ 1.1 m respectively. 相似文献
960.
Junyoung Park Sun-Hyung Ha Fukushi Abekura Hakseong Lim Young-Chae Chang Moon-Jo Lee Miri Lee Young-Choon Lee Cheorl-Ho Kim 《Journal of cellular biochemistry》2019,120(2):1742-1753
In our previous studies, structurally similar compounds of ascochlorin and ascofuranone exhibited anti-inflammatory activity. Neural inflammation plays a significant role in the commence and advancement of neurodegenerative diseases. It is not known whether 4-O-carboxymethylascochlorin (AS-6) regulates the initial stage of inflammatory responses at the cellular level in BV2 microglia cells. We here investigated the anti-inflammatory effects of AS-6 treatment in microglia cells with the microglial protection in neurons. We found that the lipopolysaccharide (LPS)-stimulated production of nitric oxide, a main regulator of inflammation, is suppressed by AS-6 in BV2 microglial cells. In addition, AS-6 dose-dependently suppressed the increase in COX-2 protein and messenger RNA levels in LPS-stimulated BV2 cells. Moreover, AS-6 inhibited the expression and secretion of proinflammatory cytokines in BV2 microglial cells. At the intracellular level, AS-6 inhibited LPS-activated nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) in BV2 microglial cells. AS-6 negatively affected mitogen-activated protein kinases (MAPK) and Akt phosphorylation: Phosphorylated forms of ERK, JNK, p38, and Akt decreased. To check whether AS-6 protects against inflammatory inducer-mediated neurotoxicity, neuronal SH-SY5Y cells were coincubated with BV2 cells in conditioned medium. AS-6 exerted a neuroprotective effect by suppressing microglial activation by LPS or amyloid-β peptide. AS-6 is a promising suppressor of inflammatory responses in LPS-induced BV2 cells by attenuating NF-κB and MAPKs signaling. AS-6 protected against microglial-mediated neurotoxicity in SH-SY5Y and BV2 cocultured cells from LPS–induced neuroinflammation and death via inhibiting MAPK, NF-κB, and Akt pathways. 相似文献