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241.
Asish Ray Chaudhuri Isao Tomita Fukutaro Mizuhashi Kyoji Murata Richard F. Ludueña 《The protein journal》1998,17(7):685-690
IKP104 is one of a group of tubulin-binding drugs whose interaction with tubulin suggests that it may bind to the protein
at or close to the region where vinblastine binds. By itself IKP104 is a potent enhancer of tubulin decay as evidenced by
the fact that it induces the exposure of the sulfhydryl groups and hydrophobic areas on tubulin. In this respect, IKP104 differs
from vinblastine and other drugs such as phomopsin A, dolastatin 10, rhizoxin, and maytansine which are competitive or noncompetitive
inhibitors of vinblastine binding. In contrast, however, in the presence of colchicine, IKP104 behaves differently and strongly
stabilizes tubulin, to an extent much greater than does colchicine alone. IKP104 appears to have two classes of binding site
on tubulin, differing in affinity; the acceleration of decay appears to be mediated by the low-affinity site (Chaudhuriet al., 1998,J. Protein Chem., in press). We investigated the relationship of the binding of IKP104 and vinblastine. We found that the high-affinity site
or sites of IKP104 overlap with or interact with the vinblastine-binding sites, but that the low-affinity site is distinctly
different. 相似文献
242.
The species composition and density of seeds in the soil of a climax evergeen oak forest in the Kasugayama Forest Reserve,
Nara, Japan were studied by directly extracting seeds from soil samples and using soil samples in planting boxes as the basis
of germination tests.
A total of 33 species were identified from all seeds collected in 6 stands: 11 evergreen broadleaf, 15 deciduous broadleaf,
2 coniferous, 2 liana, 1 herb, and 2 grass species. Species producing sap fruits and dry fruits accounted for 60% and 40%
of the total number of species, respectively. The species composition of all the seeds was independent of the species composition
of the forest vegetation. The mean density of the seeds was 22,134 seeds/m2·5 cm.Eurya japonica, of which seeds were found in all soil samples, was the most abundant species, followed byCryptomeria japonica, Ilex micrococca, andBoehmeria longispica. Pioneer species such asMallotus japonicus, Zanthoxylum ailanthoides, andAralia elata were found in all soil samples in spite of the paucity of adult trees in the forest. Seeds of evergreen oaks were relatively
aboundant but no viable seeds were found. ViableE. japonica, I. micrococca, Symplocos prunifolia, andB. longispica seeds were abundant. 相似文献
243.
Ichthyological Research - Propherallodus longipterus sp. nov. (Gobiesocidae: Diplocrepinae) is described on the basis of three specimens (17.0–22.8 mm in standard length: SL) from the... 相似文献