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131.
Gubs'kyĭ IuI Ianits'ka LV Velykyĭ MM Kuchmerovs'ka TM 《Ukrainski? biokhimicheski? zhurnal》2004,76(6):106-110
Alterations of Na+,K+-ATPase activity and serotoninergic system functioning were investigated in brain synaptosomes fractions of rats under experimental acute 1,2-dichloroethane (DChE) intoxication. It was shown that Na+,K+-ATPase activity was markedly increased (by 41,8%) in a period of 24 h after DChE intoxication and decreased (by 27%) after 48 h intoxication. The level of [2-14C]-serotonin uptake by synaptosomes was progressively diminished after 24 and 48 h after DChE injection whereas the activity of monoamine uptake proved to be unchanged. Nicotinamide (200 mg/kg of body weight) was administered to rats subjected to DChE 1, 24 and 36 h after poisoning. The treatment of rats with nicotinamide resulted in some normalization of brain synaptosomal Na+, K+-ATPase activity and serotonin uptake controlled at 48 h after DChE intoxication. 相似文献
132.
The analysis of natural foci of haemorrhagic fever with renal syndrome (HFRS) and tick-borne borreliosis on the territory of the Ulyanovsk region is presented. Reduced rat control interventions result in a wide spread of these and other infections with natural focality. Monitoring of natural foci of HFRS, tick-borne borreliosis and arbovirus infections, their typing and determination of main reservoirs are the most promising among epidemiological surveillance methods. 相似文献
133.
Osipova IG Makhaĭlova NA Sorokulova IB Vasil'eva EA Gaĭderov AA 《Zhurnal mikrobiologii, epidemiologii, i immunobiologii》2003,(3):113-119
Data on probiotic preparations prepared from spore-forming bacteria is reviewed. Information on indications for use, effectiveness and the mechanism of action is given. Preparations being produced in Russia (Biosporin, Sporobacterin and Bactosporin) are evaluated in detail as well as the prospects of the application of probiotics from spore-forming bacteria. 相似文献
134.
Detection of Treponema pallidum DNA and RNA in clinical material from patients with syphilis at different stages 总被引:2,自引:0,他引:2
135.
Kirillov DA Chaĭnikova IN Perunova NB Chelpachenko OE Pan'kov AS Smoliagin AI Valyshev AV 《Zhurnal mikrobiologii, epidemiologii, i immunobiologii》2003,(4):74-78
The effect of the synthetic immunomodulator polyoxydonium (PO) on some biological properties of pathogenic bacteria (Shigella flexneri, Salmonella enteritidis), opportunistic bacteria (Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Bacteroides fragilis, Peptostreptococcus anaerobius, Prevotella melaninogenica, Propionibacterium propionicum, Clostridium difficile) and fungi (Candida albicans), isolated during enteric infections, enteric dysbiosis, pyoinflammatory diseases, was evaluated in a number of in vitro experiments. The study revealed that the recommended therapeutic concentration of PO decreased antilysozyme activity (ALA) and the anticomplement activity in Klebsiella, Shigella, Propionibacterium, Clostridium, bacteroids, fungi of the genus Candida, but increased ALA in nonhemolytic Escherichia. Under the action of PO an increased sensitivity of the microorganisms under study to definite antibiotics of the lincosamide, fluoroquinolon, carbapenem and cephalosporin groups was noted. The data obtained in this study reveal one of the possible mechanisms of the corrective action of PO on the microbiocenosis of the intestine in dysbiosis, enteric infections and pyoinflammatory diseases. 相似文献
136.
Tuĭgunov MM Gabidullin ZG Zurochka AV Bukharin OV 《Zhurnal mikrobiologii, epidemiologii, i immunobiologii》2003,(4):23-27
Modern data on the molecular mechanisms of relationships between the host organism and the pathogenic representatives of the family Enterobacteriaceae in the host-parasite system are presented. The process of cytokine and eicosanoid regulation of the immune process of the host in the norm and pathology states are analyzed. The examples of the mechanisms of immune suppression, false antigenic stimulation and the mimicry of pathogens are given. 相似文献
137.
Zinkin VIu Mikhaĭlova NA Khvatov VB 《Zhurnal mikrobiologii, epidemiologii, i immunobiologii》2003,(4):107-109
The influence of the newly developed complex vaccine Pyopol, containing the antigens of opportunistic microorganisms and polyoxydonium used as immunomodulator, on the oxygen-dependent metabolism of neutrophils was studied. The study revealed that the main components of the vaccine, both individually and in association, did not change cellular activity in the range of concentrations used in this study. The inhibition of the oxygen-dependent metabolism of neutrophil granulocytes in the presence of native or weakly diluted vaccine occurred due to the cytotoxic effect of thimerosal used as preservative. 相似文献
138.
Ovsova LM Mazrukho AB Lomov IuM Rozhkov KK Monakhova EK Mikhas' NK Kaminskiĭ DI Kruglikov VD 《Zhurnal mikrobiologii, epidemiologii, i immunobiologii》2003,(3):16-21
The influence of amino acids and ammonium salts on the production of cholera enterotoxin (CT) by 3 Vibrio cholerae strains of different biovars and serogroups was evaluated. As revealed in this study, toxin formation in each of the strains was quantitatively and qualitatively determined by their individual sets of amino acids. The amino acid compositions ensuring the maximum production of CT by the V. cholerae strains under study were formed. The use of ammonium salts as the only source of nitrogen in the composition of a synthetic nutrient medium for the accumulation of CT was shown to be inexpedient. 相似文献
139.
Onishchenko GG Efremenko VI Briukhanova GD Malashikhin NT Vovk IuI Grizhebovskiĭ GM Koval'chuk IV Fedosova GN 《Zhurnal mikrobiologii, epidemiologii, i immunobiologii》2003,(6):10-14
The system of organizational and prophylactic measures, carried out with a view to prevent epidemiological aggravations in connection with the natural calamity in the Southern Federal District of the Russian Federation in 2003, is described. Proposals on the improvement of the system of preventive measures, including the monitoring of the epidemiological, sanitary and hygienic situation, personnel training, technical provision, the cooperation of different services and departments, capable of ensuring the liquidation of the consequences of emergency situations of the natural character, are made. 相似文献
140.