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Kucher V. V. Rozhmanova O. M. Pogorelaya N. Kh. Dolgaya E. V. Magura I. S. 《Neurophysiology》2001,33(3):148-152
We studied modulating influences of a core oligoadenylate, 2,5-ApApA, on the voltage-operated potassium channels; the agent was injected into cloned cells of the rat pheochromocytoma PC-12. Diffusion of 2,5-ApApA from a micropipette into the cell evoked clear changes in the current-voltage relationships of the integral potassium current; when positive shifts of the membrane potential reached about +20 mV, a saturation phenomenon was observed. The dependence of the probability for open state of the voltage-operated potassium channels on the membrane potential was calculated using normalization of the potassium conductance graphs; it satisfactorily fit Boltzmann's equation. Under the influence of 2,5-ApApA, activation of the potassium channels became more strongly dependent on the voltage. Within the first minutes of the action of core oligoadenylate, the potassium conductance changed by e times at a shift of the membrane potential by 12 mV, while after a stationary level of the 2,5-ApApA effect had been attained (approximately from the 25th min), the same change in the potassium conductance needed only an 8-mV shift. We conclude that 2,5-ApApA-evoked conformation modifications in the structure of the potassium channels in the cells of rat PC-12 pheochromocytoma can result from an increase in the sensitivity of voltage sensors in the above-mentioned channels to changes in the membrane potential. 相似文献
74.
A. N. Kucher A. L. Danilova L. A. Koneva A. N. Nogovitsina 《Russian Journal of Genetics》2010,46(5):610-616
Rural and urban settlements of the Republic of Sakha (Yakutia) are characterized by intense marriage migrations: both indigenous
residents of different uluses (districts) of the republic (7–30%) and migrants from outside Yakutia (7–29%) contract marriages
in five administrative centers analyzed in this respect. All the populations studied are characterized by a wide geographic
range of the birthplaces of persons contracted marriages there (from 14 to 24 uluses of Yakutia), without any predominant
migration flow from one district to another. The proportion of homolocal marriages among indigenous ethnic groups (Evenks,
Evens, and Yukagirs) is as high as 75–100%; this proportion among Yakuts varies from 26 to 68%; heterolocal marriages are
more characteristic of Russian immigrants (41–95%). Positive assortative marriages among persons with the same birthplaces
have been found in all populations except for Momsky ulus. 相似文献
75.
A simulation model has been developed for predicting the distribution of trinucleotide repeat expansion diseases in human
populations. The interface of the software used to run this model presents the options for simulating natural reproduction
of a population, with the population demographic parameters taken into account, and for simulating the appearance of a dynamic
mutation in populations, transmission of the mutant gene from parents to offspring, and the effect of the phenotypic expression
of the disease (the patients’ life expectancy and birthrate) on the transmission of the mutant allele in the patients’ families
and its accumulation in the population. 相似文献
76.
The associations between variation of morphophysiological traits, biochemical and immunological loci and incidence of repeated spontaneous abortions were examined in Moscow population. Early age of menarche, great difference in wife/husband body length and the presence of rare genotypic paired combinations for 8 biochemical and 5 immunological loci have been shown to be the main nonspecific risk factors for this type of pathology. Direct estimations of relative risk are presented. 相似文献
77.
78.
The pesticide p,p’-DDT (1-chloro-4-[2,2,2-trichloro-1-(4-chlorophenyl)ethyl]benzene) has been used in agriculture, forestry, and vector control for decades. Technical DDT, the purity commonly used for insecticidal applications, contained p,p’-DDT as well as its constitution isomer o,p’-DDT (1-chloro-2-(2,2,2-trichloro-1-(4-chlorophenyl)ethyl]benzene) and several closely related compounds. To investigate the effect of environmental processes on the isomer-specific composition of DDT and its degradation products, we examined previously published and newly acquired quantitative data with regard to o,p’-/p,p’-DDX ratios in different environmental matrices. Isomeric shifts related to the depositional regime, transfer between and within compartments, and microbial transformation were clearly observed. Shifts of the positional isomer ratios potentially can serve as indictors to track the environmental fate of DDX. For an unambiguous assignment of these shifts to specific processes, further systematic studies and complementary lab experiments are necessary. 相似文献
79.
The results of an estimation of the level of subdivision in the Buryat ethnos (obtained on the basis of data published by a number of research teams) are given. Altogether, information about 34 loci, including 25 diallelic loci and 9 STR loci, was analyzed. The results of the analysis, both for the diallelic polymorphic variants in genes predisposed to multifactorial diseases and for neutral STR markers, indicate the subdivision of the genetic structure of the different territorial groups of Buryats. The peculiarities of the ethnogenesis and heterogeneity of the settlement of Buryat tribes on the territory of residence are considered as one possible (but not the sole) explanation of the genetic heterogeneity of different territorial groups of Buryats. It is indicated that it is important to take into account information about the territorial, ethnic, and tribal affiliation of individuals (included in the studied groups) when planning studies aiming to establish a genetic component of the determination of pathological states in humans. 相似文献
80.
E. V. Filatova A. Yu. Egorov E. O. Kucher K. O. Kulagina 《Journal of Evolutionary Biochemistry and Physiology》2011,47(5):474-481
Individual characteristics of animal behavior can serve a prognostic parameter of predisposition to use of alcohol. The goal
of the work was to study dynamics of formation of preference of alcohol at early stages in the process of forced alcoholization
in male and female rats as well as the accompanying changes in behavior parameters. For 3 months, the rats were submitted
to the forced alcoholization with 10% ethanol. Each week the rats were tested in the “two-glass trial.” Individual peculiarities
of all animals were evaluated prior to, after 6 weeks, and after the end of the experiment with aid of the “open field test”
and “Suok-test.” Results showed that the male rats demonstrating by the end of the experiment the significantly higher level
of the alcohol preference, demonstrated at the initial stages of the forced alcoholization the significantly lower preference
as compared with the remaining ones. These rats also showed before alcoholization the lower levels of the motor and exploratory
activities as compared with control. On the contrary, the individuals that by the end of the experiment did not differ from
control by the level of the alcohol preference demonstrated prior to alcoholization in the “Suok-test” the higher anxiety
level. In females there was observed a positive correlation of a decrease of the anxiety level in the process of alcoholization
with a rise of ethanol consumption. Thus, in male rats, the prognostic parameter predicting formation of the abuse can serve
the degree of alcohol preference at the initial stages. 相似文献