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11.
Tatiana Mishchenko Irina Balalaeva Anastasia Gorokhova Maria Vedunova Dmitri V. Krysko 《Cell death & disease》2022,13(5)
Photodynamic therapy (PDT) was discovered more than 100 years ago. Since then, many protocols and agents for PDT have been proposed for the treatment of several types of cancer. Traditionally, cell death induced by PDT was categorized into three types: apoptosis, cell death associated with autophagy, and necrosis. However, with the discovery of several other regulated cell death modalities in recent years, it has become clear that this is a rather simple understanding of the mechanisms of action of PDT. New observations revealed that cancer cells exposed to PDT can pass through various non-conventional cell death pathways, such as paraptosis, parthanatos, mitotic catastrophe, pyroptosis, necroptosis, and ferroptosis. Nowadays, immunogenic cell death (ICD) has become one of the most promising ways to eradicate tumor cells by activation of the T-cell adaptive immune response and induction of long-term immunological memory. ICD can be triggered by many anti-cancer treatment methods, including PDT. In this review, we critically discuss recent findings on the non-conventional cell death mechanisms triggered by PDT. Next, we emphasize the role and contribution of ICD in these PDT-induced non-conventional cell death modalities. Finally, we discuss the obstacles and propose several areas of research that will help to overcome these challenges and lead to the development of highly effective anti-cancer therapy based on PDT.Subject terms: Cancer immunotherapy, Cell death and immune response 相似文献
12.
Krysko DV Diez-Fraile A Criel G Svistunov AA Vandenabeele P D'Herde K 《Apoptosis : an international journal on programmed cell death》2008,13(9):1065-1087
The vertebrate ovary is an extremely dynamic organ in which excessive or defective follicles are rapidly and effectively eliminated
early in ontogeny and thereafter continuously throughout reproductive life. More than 99% of follicles disappear, primarily
due to apoptosis of granulosa cells, and only a minute fraction of the surviving follicles successfully complete the path
to ovulation. The balance between signals for cell death and survival determines the destiny of the follicles. An abnormally
high rate of cell death followed by atresia can negatively affect fertility and eventually lead irreversibly to premature
ovarian failure. In this review we provide a short overview of the role of programmed cell death in prenatal differentiation
of the primordial germ cells and in postnatal folliculogenesis. We also discuss the issue of neo-oogenesis. Next, we highlight
molecules involved in regulation of granulosa cell apoptosis. We further discuss the potential use of scores for apoptosis
in granulosa cells and characteristics of follicular fluid as prognostic markers for predicting the outcome of assisted reproduction.
Potential therapeutic strategies for combating premature ovarian failure are also addressed. 相似文献
13.
MARIA JOSÉ ASINS IRENE VILLALTA MOHAMED M. ALY RAQUEL OLÍAS PAZ ÁLVAREZ DE MORALES RAÚL HUERTAS JUN LI NOELIA JAIME‐PÉREZ ROSARIO HARO VERÓNICA RAGA EMILIO A. CARBONELL ANDRÉS BELVER 《Plant, cell & environment》2013,36(6):1171-1191
The location of major quantitative trait loci (QTL) contributing to stem and leaf [Na+] and [K+] was previously reported in chromosome 7 using two connected populations of recombinant inbred lines (RILs) of tomato. HKT1;1 and HKT1;2, two tomato Na+‐selective class I‐HKT transporters, were found to be closely linked, where the maximum logarithm of odds (LOD) score for these QTLs located. When a chromosome 7 linkage map based on 278 single‐nucleotide polymorphisms (SNPs) was used, the maximum LOD score position was only 35 kb from HKT1;1 and HKT1;2. Their expression patterns and phenotypic effects were further investigated in two near‐isogenic lines (NILs): 157‐14 (double homozygote for the cheesmaniae alleles) and 157‐17 (double homozygote for the lycopersicum alleles). The expression pattern for the HKT1;1 and HKT1;2 alleles was complex, possibly because of differences in their promoter sequences. High salinity had very little effect on root dry and fresh weight and consequently on the plant dry weight of NIL 157‐14 in comparison with 157‐17. A significant difference between NILs was also found for [K+] and the [Na+]/[K+] ratio in leaf and stem but not for [Na+] arising a disagreement with the corresponding RIL population. Their association with leaf [Na+] and salt tolerance in tomato is also discussed. 相似文献
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15.
Malovichko OL Petrus AS Krysko AA Kabanova TA Andronati SA Karaseva TL Kiriyak AV 《Bioorganic & medicinal chemistry letters》2006,16(20):5294-5297
The novel fibrinogen receptor antagonists containing fragments of 7-amino-1,2,3,4-tetrahydroisoquinoline and isophthalic acids were synthesized and successfully tested for their ability to inhibit platelet aggregation in vitro and to block FITC-Fg binding to alpha(IIb)beta(3) on washed human platelets. 相似文献
16.
Wouter Huvenne Claudina A Pérez-Novo Lara Derycke Natalie De Ruyck Olga Krysko Tania Maes Nele Pauwels Lander Robays Ken R Bracke Guy Joos Guy Brusselle Claus Bachert 《Respiratory research》2010,11(1):100
Background
Cigarette smoke (CS) is known to initiate a cascade of mediator release and accumulation of immune and inflammatory cells in the lower airways. We investigated and compared the effects of CS on upper and lower airways, in a mouse model of subacute and chronic CS exposure.Methods
C57BL/6 mice were whole-body exposed to mainstream CS or air, for 2, 4 and 24 weeks. Bronchoalveolar lavage fluid (BAL) was obtained and tissue cryosections from nasal turbinates were stained for neutrophils and T cells. Furthermore, we evaluated GCP-2, KC, MCP-1, MIP-3α, RORc, IL-17, FoxP3, and TGF-β1 in nasal turbinates and lungs by RT-PCR.Results
In both upper and lower airways, subacute CS-exposure induced the expression of GCP-2, MCP-1, MIP-3α and resulted in a neutrophilic influx. However, after chronic CS-exposure, there was a significant downregulation of inflammation in the upper airways, while on the contrary, lower airway inflammation remained present. Whereas nasal FoxP3 mRNA levels already increased after 2 weeks, lung FoxP3 mRNA increased only after 4 weeks, suggesting that mechanisms to suppress inflammation occur earlier and are more efficient in nose than in lungs.Conclusions
Altogether, these data demonstrate that CS induced inflammation may be differently regulated in the upper versus lower airways in mice. Furthermore, these data may help to identify new therapeutic targets in this disease model. 相似文献17.
OL Garibay-Cerdenares VI Hernández-Ramírez JC Osorio-Trujillo D Gallardo-Rincón P Talamás-Rohana 《Cell Adhesion & Migration》2015,9(5):394-405
Haptoglobin (Hp) is an acute-phase protein that is produced by the liver to capture the iron that is present in the blood circulation, thus avoiding its accumulation in the blood. Moreover, Hp has been detected in a wide variety of tissues, in which it performs various functions. In addition, this protein is considered a potential biomarker in many diseases, such as cancer, including ovarian carcinoma; however, its participation in the cancerous processes has not yet been determined. The objective of this work was to demonstrate the expression of Hp and its receptor CCR2 in the ovarian cancer cells and its possible involvement in the process of cell migration through changes in the rearrangement of the actin cytoskeleton using western blot and wound-healing assays and confirming by confocal microscopy. Ovarian cancer cells express both Hp and its receptor CCR2 but only after exposure to ascitic fluid, inducing moderated cell migration. However, when the cells are exposed to exogenous Hp, the expression of CCR2 is induced together with drastic changes in the actin cytoskeleton rearrangement. At the same time, Hp induced cell migration in a much more efficient manner than did ascitic fluid. These effects were blocked when the CCR2 synthetic antagonist RS102895 was used to pretreat the cells. These results suggest that Hp-induced changes in the cell morphology, actin cytoskeleton structure, and migration ability of tumor cells, is possibly “preparing” these cells for the potential induction of the metastatic phenotype. 相似文献
18.
Andrei A. Krysko Georgiy V. Samoylenko Pavel G. Polishchuk Marina S. Fonari Victor Ch. Kravtsov Sergei A. Andronati Tatyana A. Kabanova Janusz Lipkowski Tetiana M. Khristova Victor E. Kuz’min Vladimir M. Kabanov Olga L. Krysko Alexandre A. Varnek 《Bioorganic & medicinal chemistry》2013,21(15):4646-4661
A series of novel RGD mimetics containing phthalimidine fragment was designed and synthesized. Their antiaggregative activity determined by Born’s method was shown to be due to inhibition of fibrinogen binding to αIIbβ3. Molecular docking of RGD mimetics to αIIbβ3 receptor showed the key interactions in this complex, and also some correlations have been observed between values of biological activity and docking scores. The single crystal X-ray data were obtained for five mimetics. 相似文献
19.
Abhishek D. Garg Dominika Nowis Jakub Golab Peter Vandenabeele Dmitri V. Krysko Patrizia Agostinis 《生物化学与生物物理学报:癌评论》2010
Immunogenic profile of certain cancer cell death mechanisms has been transmuted by research published over a period of last few years and this change has been so drastic that a new (sub)class of apoptotic cancer cell death, redefined as ‘immunogenic apoptosis’ has started taking shape. In fact, it has been shown that this chemotherapeutic agent-specific immunogenic cancer cell death modality has the capabilities to induce ‘anticancer vaccine effect’, in vivo. These new trends have given an opportunity to combine tumour cell kill and antitumour immunity within a single paradigm, a sort of ‘holy grail’ of anticancer therapeutics. At the molecular level, it has been shown that the immunological silhouette of these cell death pathways is defined by a set of molecules called ‘damage-associated molecular patterns (DAMPs)’. Various intracellular molecules like calreticulin (CRT), heat-shock proteins (HSPs), high-mobility group box-1 (HMGB1) protein, have been shown to be DAMPs exposed/secreted in a stress agent/factor-and cell death-specific manner. These discoveries have motivated further research into discovery of new DAMPs, new pathways for their exposure/secretion, search for new agents capable of inducing immunogenic cell death and urge to solve currently present problems with this paradigm. We anticipate that this emerging amalgamation of DAMPs, immunogenic cell death and anticancer therapeutics may be the key towards squelching cancer-related mortalities, in near future. 相似文献
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