全文获取类型
收费全文 | 632篇 |
免费 | 26篇 |
国内免费 | 1篇 |
出版年
2022年 | 13篇 |
2021年 | 14篇 |
2020年 | 18篇 |
2019年 | 16篇 |
2018年 | 26篇 |
2017年 | 13篇 |
2016年 | 25篇 |
2015年 | 36篇 |
2014年 | 41篇 |
2013年 | 59篇 |
2012年 | 39篇 |
2011年 | 49篇 |
2010年 | 34篇 |
2009年 | 20篇 |
2008年 | 38篇 |
2007年 | 30篇 |
2006年 | 26篇 |
2005年 | 27篇 |
2004年 | 14篇 |
2003年 | 18篇 |
2002年 | 8篇 |
2001年 | 6篇 |
2000年 | 4篇 |
1999年 | 3篇 |
1998年 | 2篇 |
1997年 | 4篇 |
1996年 | 2篇 |
1995年 | 3篇 |
1994年 | 3篇 |
1993年 | 2篇 |
1991年 | 3篇 |
1988年 | 8篇 |
1987年 | 5篇 |
1986年 | 2篇 |
1985年 | 6篇 |
1983年 | 5篇 |
1982年 | 2篇 |
1980年 | 3篇 |
1979年 | 2篇 |
1978年 | 3篇 |
1976年 | 1篇 |
1975年 | 2篇 |
1974年 | 5篇 |
1972年 | 4篇 |
1971年 | 1篇 |
1970年 | 2篇 |
1969年 | 3篇 |
1968年 | 1篇 |
1966年 | 2篇 |
1906年 | 1篇 |
排序方式: 共有659条查询结果,搜索用时 15 毫秒
621.
622.
623.
Biological consequences of zinc deficiency in the pathomechanisms of selected diseases 总被引:1,自引:0,他引:1
Kamil Jurowski Bernadeta Szewczyk Gabriel Nowak Wojciech Piekoszewski 《Journal of biological inorganic chemistry》2014,19(7):1069-1079
From many points of view, zinc is one of the most important trace elements in biological systems. Many articles describe the well-known role of this metal in human physiology and pathophysiology, but in the related literature, there is a lack of current and reliable reviews of the role of zinc deficiency in many diseases. In this article, we describe the role of zinc deficiency in the oxidative stress control, immune response, proliferation, and pathogenesis and pathophysiology of selected diseases such as depression, cardiovascular diseases, diabetes mellitus, Alzheimer’s disease, and Wilson’s disease. 相似文献
624.
Limited attention: the constraint underlying search image 总被引:4,自引:2,他引:2
Recent models of predator search behavior integrate proximate
neurobiological constraints with ultimate economic considerations.These models are based on two assumptions, which we have criticallyexamined in experiments with blue jays searching for artificialprey images presented on a computer monitor. We found, first,that when jays had to switch between searching for two distinctprey types, they showed no reduction in detection rates comparedto no-switching to no-switching conditions, and second, that
when jays divided attention between searching for two prey typesat the same time, they had lower detection rates than whenthey focused attention on one prey type at a time. Our resultssuggest that limited attention strongly affects predator searchpatterns and diet choice, including the ubiquitous tendencyto form search images. 相似文献
625.
626.
Dorota Gudanis Lukasz Popenda Kamil Szpotkowski Ryszard Kierzek Zofia Gdaniec 《Nucleic acids research》2016,44(5):2409-2416
Fragile X syndrome and fragile X-associated tremor/ataxia syndrome (FXTAS) are neurodegenerative disorders caused by the pathogenic expansion of CGG triplet repeats in the FMR1 gene. FXTAS is likely to be caused by a ‘toxic’ gain-of-function of the FMR1 mRNA. We provide evidence for the existence of a novel quadruplex architecture comprising CGG repeats. The 8-bromoguanosine (BrG)-modified molecule GCBrGGCGGC forms a duplex in solution and self-associates via the major groove to form a four-stranded, antiparallel (GCBrGGCGGC)4 RNA quadruplex with BrG3:G6:BrG3:G6 tetrads sandwiched between mixed G:C:G:C tetrads. Self-association of Watson–Crick duplexes to form a four-stranded structure has previously been predicted; however, no experimental evidence was provided. This novel four-stranded RNA structure was characterized using a variety of experimental methods, such as native gel electrophoresis, NMR spectroscopy, small-angle X-ray scattering and electrospray ionization mass spectrometry. 相似文献
627.
628.
Autism spectrum disorders (ASD) are characterized by impairments in language and communication development, social behavior, and the occurrence of stereotypic patterns of behavior and interests. Despite substantial speculation about causes of ASD, its exact etiology remains unknown. Recent studies highlight a link between immune dysfunction and behavioral traits. Various immune anomalies, including humoral and cellular immunity along with abnormalities at the molecular level, have been reported. There is evidence of altered immune function both in cerebrospinal fluid and peripheral blood. Several studies hypothesize a role for neuroinflammation in ASD and are supported by brain tissue and cerebrospinal fluid analysis, as well as evidence of microglial activation. It has been shown that immune abnormalities occur in a substantial number of individuals with ASD. Identifying subgroups with immune system dysregulation and linking specific cellular immunophenotypes to different symptoms would be key to defining a group of patients with immune abnormalities as a major etiology underlying behavioral symptoms. These determinations would provide the opportunity to investigate causative treatments for a defined patient group that may specifically benefit from such an approach. This review summarizes recent insights into immune system dysfunction in individuals with ASD and discusses the potential implications for future therapies. 相似文献
629.
Zdenek Fric Vladimir Hula Martina Klimova Kamil Zimmermann Martin Konvicka 《Ecological Research》2010,25(3):543-552
Both species-specific traits and landscape configuration, such as area and connectivity of habitat patches plus the character
of uninhabitable matrix, affect animal movements in fragmented landscapes. Difficulties with disentangling species-specific
and landscape effects have obscured comparisons among species, hindering the understanding of dispersal in metapopulations.
To circumvent this complication, we performed a mark–recapture study of four related nymphalid butterflies within identical
landscape and in single season. The studied species were three Melitaeinae checkerspots (Euphydryas aurinia, Melitaea athalia, Melitaea diamina) and one Argynnini fritillary (Brenthis ino). Applying the Virtual Migration model revealed that (1) except for mortality within habitat, model parameters differed from
those found for the studied species elsewhere; (2) the three Melitaeinae species were more akin in movement parameters than
the Argynnini representative (i.e., B. ino); (3) within Melitaeinae, differences between sexes were more prominent than differences among species; (4) Melitaeinae males
left natal patches more readily than females, while the opposite applied to B. ino; (5) males of M. diamina and both sexes of B. ino exhibited highest values of dispersal mortality; (6) except for females of M. diamina and both sexes of B. ino, immigration and emigration scaled with area in females but not in males. Finding (1) demonstrates that geometry of habitat
network affects mobility considerably and that transferring dispersal parameters across systems is unwarranted. Still, (2–6)
demonstrate that within identical networks, related species follow similar dispersal patterns, suggesting that conservation
scenarios suitable for a well-studied model species would suite related species as well. 相似文献
630.
Mayuri Sharma Jeremy P. Kamil Margaret Coughlin Natalia I. Reim Donald M. Coen 《Journal of virology》2014,88(1):249-262
Herpesvirus nucleocapsids traverse the nuclear envelope into the cytoplasm in a process called nuclear egress that includes disruption of the nuclear lamina. In several herpesviruses, a key player in nuclear egress is a complex of two proteins, whose homologs in human cytomegalovirus (HCMV) are UL50 and UL53. However, their roles in nuclear egress during HCMV infection have not been shown. Based largely on transfection studies, UL50 and UL53 have been proposed to facilitate disruption of the nuclear lamina by recruiting cellular protein kinase C (PKC), as occurs with certain other herpesviruses, and/or the viral protein kinase UL97 to phosphorylate lamins. To investigate these issues during HCMV infection, we generated viral mutants null for UL50 or UL53. Correlative light electron microscopic analysis of null mutant-infected cells showed the presence of intranuclear nucleocapsids and the absence of cytoplasmic nucleocapsids. Confocal immunofluorescence microscopy revealed that UL50 and UL53 are required for disruption of the nuclear lamina. A subpopulation of UL97 colocalized with the nuclear rim, and this was dependent on UL50 and, to a lesser extent, UL53. However, PKC was not recruited to the nuclear rim, and its localization was not affected by the absence of UL50 or UL53. Immunoprecipitation from cells infected with HCMV expressing tagged UL53 detected UL97 but not PKC. In summary, HCMV UL50 and UL53 are required for nuclear egress and disruption of nuclear lamina during HCMV infection, and they recruit UL97, not PKC, for these processes. Thus, despite the strong conservation of herpesvirus nuclear egress complexes, a key function can differ among them. 相似文献