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排序方式: 共有278条查询结果,搜索用时 31 毫秒
271.
Slobodan R. Sekulić Damir Lukač Minja Drapšin Ivan Čapo Dušan Lalošević Aleksandra Novakov-Mikić 《Central European Journal of Biology》2009,4(1):58-61
Ultrasonography has not previously been used for studying fetal movements in precocial rodents. The objective of this study
was to ultrasonographically determine the sequence of the appearance of basic movements in a guinea pig fetus. The research
included eight guinea pig females carrying one fetus each. Fetal movements were observed for 10 minutes each day, from the
25th to 38th day of gestation. The time and sequence of the appearance of movements was observed as follows: whole body flexion
(mean 27.6 SD ± 1.68), whole body extension (mean 28.1 SD ± 1.12), head flexion (mean 28.1 SD ± 1.80), head extension (mean
30.5 SD ± 2.67) forelimbs flexion (mean 30.5 SD ± 2.32), forelimbs extension (mean 30.7 SD ± 1.84), trunk rotation (mean 31.9
SD ± 2.23), forelimbs alternating flexion and extension (mean 32.1 SD ± 2.1), hind limbs extension (mean 32.2 SD ± 3.2), hind
limbs flexion (mean 32.4 SD ± 3.16), and hind limbs alternating flexion and extension (mean 33.5 SD ± 2.39). The identical
sequences of basic movement appearances in guinea pigs, sheep, and rats suggest that the rostrocaudal gradient of basic movement
appearance could be a general developmental pattern in mammalian species. 相似文献
272.
Christoph U. Correll Samuele Cortese Giovanni Croatto Francesco Monaco Damir Krinitski Gonzalo Arrondo Edoardo
G. Ostinelli Caroline Zangani Michele Fornaro Andrs Estrad Paolo FusarPoli Andre F. Carvalho Marco Solmi 《World psychiatry》2021,20(2):244
Top‐tier evidence on the safety/tolerability of 80 medications in children/adolescents with mental disorders has recently been reviewed in this journal. To guide clinical practice, such data must be combined with evidence on efficacy and acceptability. Besides medications, psychosocial interventions and brain stimulation techniques are treatment options for children/adolescents with mental disorders. For this umbrella review, we systematically searched network meta‐analyses (NMAs) and meta‐analyses (MAs) of randomized controlled trials (RCTs) evaluating 48 medications, 20 psychosocial interventions, and four brain stimulation techniques in children/adolescents with 52 different mental disorders or groups of mental disorders, reporting on 20 different efficacy/acceptability outcomes. Co‐primary outcomes were disease‐specific symptom reduction and all‐cause discontinuation (“acceptability”). We included 14 NMAs and 90 MAs, reporting on 15 mental disorders or groups of mental disorders. Overall, 21 medications outperformed placebo regarding the co‐primary outcomes, and three psychosocial interventions did so (while seven outperformed waiting list/no treatment). Based on the meta‐analytic evidence, the most convincing efficacy profile emerged for amphetamines, methylphenidate and, to a smaller extent, behavioral therapy in attention‐deficit/hyperactivity disorder; aripiprazole, risperidone and several psychosocial interventions in autism; risperidone and behavioral interventions in disruptive behavior disorders; several antipsychotics in schizophrenia spectrum disorders; fluoxetine, the combination of fluoxetine and cognitive behavioral therapy (CBT), and interpersonal therapy in depression; aripiprazole in mania; fluoxetine and group CBT in anxiety disorders; fluoxetine/selective serotonin reuptake inhibitors, CBT, and behavioral therapy with exposure and response prevention in obsessive‐compulsive disorder; CBT in post‐traumatic stress disorder; imipramine and alarm behavioral intervention in enuresis; behavioral therapy in encopresis; and family therapy in anorexia nervosa. Results from this umbrella review of interventions for mental disorders in children/adolescents provide evidence‐based information for clinical decision making. 相似文献
273.
274.
Martina Malnar Marko Kosicek Stefan Mitterreiter Damir Omerbasic Stefan F. Lichtenthaler Alison Goate Silva Hecimovic 《生物化学与生物物理学报:疾病的分子基础》2010,1802(7-8):682-691
The link between cholesterol and Alzheimer's disease has recently been revealed in Niemann–Pick type C disease. We found that NPC1?/? cells show decreased expression of APP at the cell surface and increased processing of APP through the β-secretase pathway resulting in increased C99, sAPPβ and intracellular Aβ40 levels. This effect is dependent on increased cholesterol levels, since cholesterol depletion reversed cell surface APP expression and lowered Aβ/C99 levels in NPC1?/? cells to the levels observed in wt cells. Finding that overexpression of C99, a direct γ-secretase substrate, does not lead to increased intracellular Aβ levels in NPC1?/? cells vs. CHOwt suggests that the effect on intracellular Aβ upon cholesterol accumulation in NPC1?/? cells is not due to increased APP cleavage by γ-secretase. Our results indicate that cholesterol may modulate APP processing indirectly by modulating APP expression at the cell surface and thus its cleavage by β-secretase. 相似文献
275.
Ašić Adna Salazar Ramona Storm Niels Doğan Serkan Höppner Wolfgang Marjanović Damir Primorac Dragan 《Molecular biology reports》2021,48(6):5181-5186
Molecular Biology Reports - Human gene F5, encoding coagulation factor V, was previously reported to be highly polymorphic. Apart from FV Leiden, several other rare variants have been detected in... 相似文献
276.
Damir Vidović 《Immunogenetics》1989,30(3):194-199
Two sets of genes control the immune response ofH-2
d
mice to the synthetic antigen poly(Glu50Tyr50) (GT). One set involves class II major histocompatibility complex (Mhc) loci encoding an Ad product that serves as a recognition context to GT-reactive helper T cells (Th). The other one is a background gene, the product of which, in association with the same Mhc-restricting element, mimics
the GT/Ad complex. Mice expressing the GT-mimicking background-encoded structure (Imgt), which is preferentially displayed on B lymphoblasts, do not respond to GT as a consequence of self-tolerance. On the other
hand, elimination of cells bearing Imgt renders these mice responsive to GT, demonstrating that tolerance to self can impoverish the immune system. Imgt is probably not identical to GT, but resembles it in the way it forms complexes with Ad molecules ofMhc. 相似文献
277.
278.
Damir Vili
i 《International Review of Hydrobiology》1985,70(6):829-843
The phytoplankton biomass expressed as total cell volume is often of doubtful value due to cell size and volume variations in the organisms present. Cell volume calculations for 95 phytoplankton species and volume-frequency diagrams for 25 dominant species were analyzed for the Adriatic Sea. Recommendations for more precise work dealing with phytoplankton cell volume and biomass are given. Temporal variations in the average microplankton cell volume are presented and discussed. 相似文献