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A toxic shock syndrome toxin mutant of Staphylococcus aureus isolated by allelic replacement lacks virulence in a rabbit uterine model 总被引：1，自引：0，他引：1
Rhona Sloane Joyce C.S. de Azavedo John P. Arbuthnott Patrick J. Hartigan Barry Kreiswirth Richard Novick Timothy J. Foster 《FEMS microbiology letters》1991,78(2-3):239-244
The gene coding for toxic shock syndrome toxin-1 in S. aureus was inactivated by allelic replacement in two TSS-associated strains. One mutant derived from FRI1169 (a non-enterotoxigenic strain) lacked virulence in the rabbit uterine chamber infection model. This suggests that TSST-1 is the only determinant produced by this strain that can induce the symptoms of shock in rabbits. A novel method for allelic replacement involving transduction of plasmid integrants is described. 相似文献