Molecular and Cellular Biochemistry - Cisplatin has been extensively used as a chemotherapeutic agent since around 40 years, though its usage is limited due to severe adverse effects like... 相似文献
Numerous investigations demonstrate a novel role of thyroid hormone as a modulator of signal transduction. Protein kinase C (PKC) is critical to the mechanism by which thyroid hormones potentiate both the antiviral and immunomodulatory actions of IFNγ in different cells and regulate the exchange of signalling phospholipids in hepatocytes. Because nothing is known about accumulation of PKC modulator - diacylglycerol in cells treated with T4, we examined the nongenomic effect of thyroid hormones on DAG formation and phospholipase activation in liver cells. 相似文献
Inflammation is a pathophysiological response to infection or tissue damage during which high levels of reactive oxygen and nitrogen species are produced by phagocytes to kill microorganisms. Reactive oxygen and nitrogen species serve also in the complex regulation of inflammatory processes. Recently, it has been proposed that peroxiredoxins may play key roles in innate immunity and inflammation. Indeed, peroxiredoxins are evolutionarily conserved peroxidases able to reduce, with high rate constants, hydrogen peroxide, alkyl hydroperoxides and peroxynitrite which are generated during inflammation. In this minireview, we point out different possible roles of peroxiredoxins during inflammatory processes such as cytoprotective enzymes against oxidative stress, modulators of redox signaling, and extracellular pathogen- or damage-associated molecular patterns. A better understanding of peroxiredoxin functions in inflammation could lead to the discovery of new therapeutic targets. 相似文献
The boron content was determined in 42 different foods consumed in Istanbul, Turkey. Eleven species of fruit, ten species of vegetable, eight species of food of animal origin, four species of grain, two species of nuts, two species of legume, and five other kinds of foods were included to this study. They were analyzed by two methods: Inductively coupled plasma mass spectrometry (ICP-MS) technique and carminic acid assay, and the results of two methods were also compared. Boron concentration in foods ranged between 0.06–37.2 mg/kg. Nuts had the highest boron content while foods of animal origin had the lowest. A strong correlation was found between the results of the carminic acid assay and the ICP-MS technique (p = 0.0001, Pearson correlation coefficient: r = 0.956). Bland Altman analysis also supported this correlation. ICP-MS is one of the most common, reliable, and powerful method for boron determination. The results of our study show that spectrophotometric carminic acid assay can provide similar results to ICP-MS, and the boron content in food materials can be also determined by spectrophotometric method.
We studied assemblages of soft-walled, single-chambered foraminifera (monothalamids) at eight stations in the area of Zernov's Phyllophora Field (ZPF) on the NW continental shelf of the Black Sea. This work is based on samples collected during Cruise 70 of the RV Professor Vodyanitsky and provides the first analysis of the taxonomic composition of monothalamids from this region. These delicate, poorly known foraminifera were found at all stations in the studied area. They were represented by nine forms that are identified to species or genus level as well as 14 undescribed species, nine of which are found in the Black Sea for the first time. Four species, Psammophaga sp., Vellaria pellucida, Goodayia rostellata and Krymia fusiformis, were most abundant, with Psammophaga sp. being the dominant species overall. Previous studies have suggested a link between members of this genus and eutrophication. There are a number of taxonomic parallels between these ZPF assemblages and those from the Adriatic Sea, e.g. the occurrence of the genera Goodayia, Psammophaga and Vellaria, although it is possible that some other taxa are endemic to the Black Sea. 相似文献