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排序方式: 共有121条查询结果,搜索用时 15 毫秒
81.
82.
Pobezhimova TP Grabelnych OI Kolesnichenko AV Voinikov VK 《Journal of thermal biology》2001,26(2):95-101
A difference between the uncoupling action of constituently synthesised and stress-induced forms of winter rye stress uncoupling protein CSP 310 on winter wheat mitochondria in vitro was found from the initiation of incubation. The uncoupling activity of CSP 310 depended on its concentration in the incubation media. The addition of anti-CSP 310 antiserum to isolated mitochondria from stressed winter rye shoots caused coupling of oxidation and phosphorylation. Western-blot analysis did not locate dehydrins K-segment in CSP 310 subunits. 相似文献
83.
84.
Zykova VV Grabelnych OI Antipina AI Koroleva NA Vladimirova SV Kolesnichenko AV Pobezhimova TP Voinikov VK 《Journal of thermal biology》2000,25(5):323-327
The effect of CSP 310 on lipid peroxidation in winter wheat mitochondria was studied by the measurement of primary lipid peroxidation products - dienic conjugates. It was found that some concentrations of CSP 310 caused lipid peroxidation in isolated winter wheat mitochondria in all systems investigated at different concentrations during chilling stress. 相似文献
85.
Biophysics - An assessment of the dynamics of changes in their concentration in the lacrimal fluid over time is required for an effective dosage of ophthalmic drugs. This paper provides examples of... 相似文献
86.
Pobezhimova T. P. Grabel'nykh O. I. Kolesnichenko A. V. Sumina O. N. Voinikov V. K. 《Russian Journal of Plant Physiology》2001,48(2):204-209
We studied the localization of polypeptides immunochemically related to subunits of cold-shock 310-kD protein from winter rye (Secale cerealeL.) in mitochondria and submitochondrial structures of winter wheat (Triticum aestivumL.) seedlings. Polypeptides were separated by SDS-PAGE and probed with the antibody against 310-kD protein from rye seedlings. Wheat mitochondria contained the following polypeptides cross-reacting with this antibody: 66, 60, 55, and 23 kD in the inner membrane; 60 and 58 kD in the outer membrane; and 66 and 55 kD in the matrix. 相似文献
87.
Marina Kolesnichenko Nadine Mikuda Uta E Hpken Eva Krgel Bora Uyar Ahmet Bugra Tufan Maja Milanovic Wei Sun Inge Krahn Kolja Schleich Linda von Hoff Michael Hinz Michael Willenbrock Sabine Jungmann Altuna Akalin Soyoung Lee Ruth SchmidtUllrich Clemens A Schmitt Claus Scheidereit 《The EMBO journal》2021,40(6)
88.
JENLS CHAURMW 《Cell research》1990,1(2):173-180
Retinal ganglion cells in the rat were studied using the heavy metal intensified cytochrome oxidase and horseradish peroxidase histochemical methods.The results show that a population of large retinal ganglion cells was consistently observed with the cytochrome oxidase staining method in retinas of normal rats or rats which received unilateral thalamotomy at birth.These cytochrome oxidase rich ganglion cells appeared to have large somata,3-6 primary dendrites and extensive dendritic arbors,and are comparable to ganglion cells labeled by the wheat germ agglutinin conjugated to horseradish peroxidase (WGA-HRP).However,the morphological details of some of the cells revealed by the cytochrome oxidase staining method are frequently better than those shown by the HRP histochemical method.These results suggest that the mitochondrial enzyme cytochrome oxidase can be used as a simple but reliable marker for identifying and studying a population of retinal genglion cells with high metabolic rate in the rat. 相似文献
89.
A. S. Gorina L. S. Kolesnichenko V. I. Mikhnovich 《Biochemistry (Moscow) Supplemental Series B: Biomedical Chemistry》2011,5(4):397-401
In a stable state children with Asperger’s and Kanner’s syndromes demonstrate a similar decrease in plasma norepinephrine.
In the aggravated state, these changes become more expressed and are characterized by a decrease in plasma tyrosine, norepinephrine,
normetanephrine, and by an increase in dopamine and homovanillic acid and a decrease in excretion of norepinephrine and an
increase in excretion of homovanillic acid, epinephrine and 3-methoxy-4-hydroxyphenylglycol (MHPG). In the aggravated state
children with Kanner’s syndrome were characterized by increased plasma MHPG, decreased excretion of tyrosine and increased
expression of normetanephrine. The observed imbalance in dopamine and epinephrine/norepinephrine systems suggests importance
of combined analysis of changes in catecholamines and their metabolites as the most informative approach in the study of the
effect of autistic disorders. 相似文献
90.
Tuberous sclerosis complex proteins 1 and 2 control serum-dependent translation in a TOP-dependent and -independent manner 下载免费PDF全文
Bilanges B Argonza-Barrett R Kolesnichenko M Skinner C Nair M Chen M Stokoe D 《Molecular and cellular biology》2007,27(16):5746-5764
The tuberous sclerosis complex (TSC) proteins TSC1 and TSC2 regulate protein translation by inhibiting the serine/threonine kinase mTORC1 (for mammalian target of rapamycin complex 1). However, how TSC1 and TSC2 control overall protein synthesis and the translation of specific mRNAs in response to different mitogenic and nutritional stimuli is largely unknown. We show here that serum withdrawal inhibits mTORC1 signaling, causes disassembly of translation initiation complexes, and causes mRNA redistribution from polysomes to subpolysomes in wild-type mouse embryo fibroblasts (MEFs). In contrast, these responses are defective in Tsc1(-/-) or Tsc2(-/-) MEFs. Microarray analysis of polysome- and subpolysome-associated mRNAs uncovered specific mRNAs that are translationally regulated by serum, 90% of which are TSC1 and TSC2 dependent. Surprisingly, the mTORC1 inhibitor, rapamycin, abolished mTORC1 activity but only affected approximately 40% of the serum-regulated mRNAs. Serum-dependent signaling through mTORC1 and polysome redistribution of global and individual mRNAs were restored upon re-expression of TSC1 and TSC2. Serum-responsive mRNAs that are sensitive to inhibition by rapamycin are highly enriched for terminal oligopyrimidine and for very short 5' and 3' untranslated regions. These data demonstrate that the TSC1/TSC2 complex regulates protein translation through mainly mTORC1-dependent mechanisms and implicates a discrete profile of deregulated mRNA translation in tuberous sclerosis pathology. 相似文献