排序方式: 共有206条查询结果,搜索用时 871 毫秒
201.
Canan Uluoglu Ugur Hodoglugil H. Zafer Güney C. Zafer Görgün Nurettin Abacioglu Hakan Zengil 《Biological Rhythm Research》2013,44(4):343-352
The presence of temporal patterns in the responses of vascular smooth muscle to relaxing agents have been known. The aim of this study was to examine the variations in the in vitro sensitivity of rat aorta to papaverine and theophylline in both endothelium-intact and -denuded rings. The animals were synchronized with a 12-h light: 12-h dark schedule. Rat thoracic aorta rings were obtained from animals sacrificed at six different times (09:00, 13:00, 17:00, 21:00, 01:00 and 05:00) of the day. Tissues were precontracted submaximally with phenylephrine and then were relaxed by papaverine (10?8 ? 10?4 M) and theophylline (10?7 ? 10?3 M) applied cumulatively. The responses to most of the concentrations and EC50 values for papaverine demonstrated an ultradian rhythm with an 8 h periodicity. Time-dependent variations were not found in the responses to theophylline. The results are discussed in relation with the time-dependent differences in signal transducing mechanisms. 相似文献
202.
Laura Bousset Amandine Septier Julio Bunay Allison Voisin Rachel Guiton Christelle Damon-Soubeyrant Yoan Renaud Anglique De Haze Vincent Sapin Anne Fogli Amandine Rambur Cyrille De Joussineau Ayhan Kocer Amalia Trousson Joëlle Henry-Berger Marcus Hring Gerhard Liebisch Silke Matysik Jean-Marc A. Lobaccaro Laurent Morel Silvre Baron 《PLoS biology》2020,18(12)
Chronic inflammation is now a well-known precursor for cancer development. Infectious prostatitis are the most common causes of prostate inflammation, but emerging evidence points the role of metabolic disorders as a potential source of cancer-related inflammation. Although the widely used treatment for prostate cancer based on androgen deprivation therapy (ADT) effectively decreases tumor size, it also causes profound alterations in immune tumor microenvironment within the prostate. Here, we demonstrate that prostates of a mouse model invalidated for nuclear receptors liver X receptors (LXRs), crucial lipid metabolism and inflammation integrators, respond in an unexpected way to androgen deprivation. Indeed, we observed profound alterations in immune cells composition, which was associated with chronic inflammation of the prostate. This was explained by the recruitment of phagocytosis-deficient macrophages leading to aberrant hyporesponse to castration. This phenotypic alteration was sufficient to allow prostatic neoplasia. Altogether, these data suggest that ADT and inflammation resulting from metabolic alterations interact to promote aberrant proliferation of epithelial prostate cells and development of neoplasia. This raises the question of the benefit of ADT for patients with metabolic disorders.Mice lacking the liver X nuclear receptors (LXRs), crucial integrators of lipid metabolism, were used to study the response of the prostate to androgen deprivation. This reveals that lack of androgens leads to chronic inflammation due to impaired clearance of castration-induced apoptotic cells, allowing production of pro-inflammatory cytokines and promoting prostate neoplasia. 相似文献
203.
Dr. Alessandra Acquaviva Dr. Nilofar Prof. Dr. Abdelhakim Bouyahya Prof. Dr. Gokhan Zengin Dr. Simonetta Cristina Di Simone Prof. Dr. Lucia Recinella Prof. Dr. Sheila Leone Prof. Dr. Luigi Brunetti Prof. Dr. Abdullahi Ibrahim Uba Prof. Dr. Ugur Cakilcioğlu Prof. Dr. Rıdvan Polat Prof. Dr. Ekrem Darendelioglu Prof. Dr. Luigi Menghini Prof. Dr. Claudio Ferrante Dr. Maria Loreta Libero Prof. Dr. Giustino Orlando Prof. Dr. Annalisa Chiavaroli 《化学与生物多样性》2023,20(8):e202300547
Artemisia annua L. (Asteraceae Family) is an important plant in Asia that has been used for treating different diseases, including fever due to malaria, wounds, tubercolisis, scabues, pain, convulsions, diabetes, and inflammation. In this study we aimed to evaluate the effects of different polarity extracts (hexane, dichloromethane, ethyl acetate, ethanol, ethanol/water (70 %) and water) from A. annua against the burden of inflammation and oxidative stress occurring in colon tissue exposed to LPS. In parallel, chemical composition, antiradical, and enzyme inhibition effects against α-amylase, α-glucosidase, tyrosinase, and cholinesterases were evaluated. The water extract contained the highest content of the total phenolic with 34.59 mg gallic acid equivalent (GAE)/g extract, while the hexane had the highest content of the total flavonoid (20.06 mg rutin equivalent (RE)/g extract). In antioxidant assays, the polar extracts (ethanol, ethanol/water and water) exhibited stronger radical scavenging and reducing power abilities when compared to non-polar extracts. The hexane extract showed the best AChE, tyrosinase and glucosidase inhibitory effects. All extracts revealed effective anti-inflammatory agents, as demonstrated by the blunting effects on COX-2 and TNFα gene expression. These effects seemed to be not related to the only phenolic content. However, it is worthy of interest to highlight how the higher potency against LPS-induced gene expression was shown by the water extract ; thus suggesting a potential phytotherapy application in the management of clinical symptoms related to inflammatory colon diseases, although future in vivo studies are needed to confirm such in vitro and ex vivo observations. 相似文献
204.
205.
206.
Ugur Hodoglugil Zuhal A. Keskil C. Zafer Görgün Canan Uluoglu Nurettin Abacioglu Hakan Zengil 《Biological Rhythm Research》2013,44(4):434-444
Temporal variations in the endothelium-dependent relaxant effects of acetylcholine (ACh) in mice and histamine (HA) in rat thoracic aorta have been studied. The relaxations induced by higher concentrations of ACh and HA were significantly dependent on the time the tissues were obtained. However, neither EC 50 (the concentration inducing half of the maximum response) values for ACh and HA, nor K B (antagonist dissociation constant) values for atropine and diphenhydramine were found to be statistically significant depending upon the time of obtaining aorta preparations. These results show that the in vitro responsiveness of mice and rat thoracic aortas to endothelium-dependent relaxant effects of ACh and HA, respectively, changes over a 24-h period. These variations might be dependent on a temporal rhythm in post-receptor events, i.e., guanylate cyclase-cGMP-phosphodiesterase system which mediates responses to endothelium-derived relaxing factor(s). 相似文献